Ty Cobb has put up the most career runs by a left-hander, with 2,244 runs.

	NAME	R	G	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS	WRC	WRAA	WOBA	WRC+	BRAA
1	Ty Cobb T. Cobb	2,244	3,034	11,434	4,189	724	295	117	1,933	1,249	94	681	897		13,068	5,854	1,136	291				.366	.433	.512	.945	2534	1,093.6	.445	165	975.1
2	Barry Bonds B. Bonds	2,227	2,986	9,847	2,935	601	77	762	1,996	2,558	106	1,539	514	141	12,606	5,976	1,440	4	91	688	165	.298	.444	.607	1.051	2663	1,143.3	.435	172	1,142
3	Babe Ruth B. Ruth	2,174	2,503	8,399	2,873	506	136	714	2,214	2,062	43	1,330	123		10,617	5,793	1,356	113				.342	.474	.690	1.164	2727	1,436.8	.513	197	1,369.6
4	Stan Musial S. Musial	1,949	3,026	10,972	3,630	725	177	475	1,951	1,599	53	696	78	31	12,712	6,134	1,377	35	53	127	243	.331	.417	.559	.976	2474	1,032.5	.435	158	896.7
5	Lou Gehrig L. Gehrig	1,888	2,164	8,001	2,721	534	163	493	1,995	1,508	45	790	102		9,660	5,060	1,190	106			2	.340	.447	.632	1.080	2265	1,046.8	.477	173	980
6	Tristram Speaker T. Speaker	1,882	2,789	10,195	3,514	792	222	117	1,531	1,381	103	394	436		11,988	5,101	1,131	309				.345	.428	.500	.928	2264	921	.436	157	812.3
7	Mel Ott M. Ott	1,859	2,730	9,456	2,876	488	72	511	1,860	1,708	64	896	89		11,337	5,041	1,071	109			38	.304	.414	.533	.947	2204	826.4	.430	156	794.2
8	Eddie Collins E. Collins	1,821	2,826	9,949	3,315	438	187	47	1,300	1,499	77	468	741		12,037	4,268	672	512				.333	.424	.429	.853	2032	693.4	.409	144	619.7
9	Carl Yastrzemski C. Yastrzemski	1,816	3,308	11,988	3,419	646	59	452	1,844	1,845	40	1,393	168	116	13,991	5,539	1,157	13	105	190	323	.285	.379	.462	.841	2155	643.2	.375	130	469.8
10	Ted Williams T. Williams	1,798	2,292	7,706	2,654	525	71	521	1,839	2,021	39	709	24	4	9,791	4,884	1,117	5	20	86	197	.344	.482	.634	1.116	2349	1,219.7	.493	188	1,067
11	Charlie Gehringer C. Gehringer	1,775	2,323	8,860	2,839	574	146	184	1,427	1,186	50	372	181		10,237	4,257	904	141			27	.320	.404	.480	.884	1797	516.6	.405	124	350
12	Jesse Burkett J. Burkett	1,720	2,067	8,426	2,850	320	182	75	952	1,029	75	561	389		9,620	3,759	577	90				.338	.415	.446	.861	1921	592.9	.411	137	526.7
13	Willie Keeler W. Keeler	1,719	2,123	8,591	2,932	241	145	33	810	524	129	136	495		9,610	3,562	419	366				.341	.388	.415	.802	1640	406.6	.383	124	330.8
14	Billy Hamilton B. Hamilton	1,697	1,594	6,283	2,164	242	95	40	742	1,189	89	271	914		7,608	2,716	377	47				.344	.455	.432	.888	1716	578.6	.433	142	505.5
15	Johnny Damon J. Damon	1,668	2,490	9,736	2,769	522	109	235	1,139	1,003	50	1,257	408	103	10,917	4,214	866	57	71	38	93	.284	.352	.433	.785	1471	131.2	.344	105	69.7
16	Rafael Palmeiro R. Palmeiro	1,663	2,831	10,472	3,020	585	38	569	1,835	1,353	87	1,348	97	40	12,046	5,388	1,192	15	119	172	232	.288	.371	.515	.885	1975	522.8	.380	130	453.5
17	Ken Griffey Jr. K. Griffey Jr.	1,662	2,671	9,801	2,781	524	38	630	1,836	1,312	81	1,779	184	69	11,304	5,271	1,192	8	102	246	199	.284	.370	.538	.907	1892	521.1	.384	132	453.4
18	Joe Morgan J. Morgan	1,650	2,649	9,277	2,517	449	96	268	1,133	1,865	40	1,015	689	162	11,329	3,962	813	51	96	76	105	.271	.392	.427	.819	1717	490	.372	135	447.2
19	George Van Haltren G. Van Haltren	1,642	1,990	8,043	2,544	286	161	69	1,015	871	38	385	583		9,017	3,359	516	65				.316	.386	.418	.803	1647	328.4	.384	119	259.3
20	Paul Waner P. Waner	1,627	2,549	9,459	3,152	605	191	113	1,309	1,091	38	376	104		10,762	4,478	909	174			45	.333	.404	.473	.878	1868	537	.403	135	487.9
21	Fred Clarke F. Clarke	1,622	2,246	8,584	2,678	361	220	67	1,015	875	154	511	509		9,838	3,680	648	225				.312	.386	.429	.814	1663	445.8	.390	131	386.2
22	Roger Connor R. Connor	1,620	1,998	7,797	2,467	441	233	138	1,071	1,002	39	151	244		8,847	3,788	812	9				.316	.397	.486	.883	1952	630.3	.409	142	569.9
23	Lou Brock L. Brock	1,610	2,616	10,332	3,023	486	141	149	900	761	49	1,730	938	307	11,235	4,238	776	47	46	124	114	.293	.343	.410	.753	1406	210.2	.336	109	113.1
24	Jake Beckley J. Beckley	1,602	2,389	9,538	2,934	473	244	87	1,578	616	183	442	315		10,504	4,156	804	167				.308	.361	.436	.797	1803	356.2	.376	119	288.8
25	Jim Thome J. Thome	1,583	2,543	8,422	2,328	451	26	612	1,699	1,747	69	2,548	19	20	10,313	4,667	1,089	1	74	173	165	.276	.402	.554	.956	1925	653.9	.406	145	589.5