Joe Mauer has collected the most career hits for the Twins against left-handed pitchers, with 646 hits.

	NAME	H	G	AB	2B	3B	HR	RBI	BB	HBP	SO	PA	TB	XBH	SH	SF	IBB	AVG	OBP	SLG	OPS
1	Joe Mauer J. Mauer	646	1,153	2,231	96	4	33	298	237	19	375	2,511	849	133	2	22	14	.290	.360	.381	.740
2	Kirby Puckett K. Puckett	644	781	1,912	119	23	65	279	139	4	245	2,071	1,004	207	4	12	34	.337	.381	.525	.906
3	Kent Hrbek K. Hrbek	459	865	1,696	69	3	58	289	195	11	287	1,934	708	130	14	18	1	.271	.346	.417	.764
4	Justin Morneau J. Morneau	420	837	1,673	92	4	57	288	104	15	316	1,809	691	153	0	17	6	.251	.298	.413	.711
5	Torii Hunter T. Hunter	392	674	1,413	80	8	65	235	117	8	286	1,552	683	153	1	13	24	.277	.333	.483	.817
6	Gary Gaetti G. Gaetti	381	661	1,471	64	8	65	218	130	5	237	1,626	656	137	3	17	18	.259	.318	.446	.764
7	Michael Cuddyer M. Cuddyer	365	616	1,260	92	6	50	170	177	6	247	1,450	619	148	1	6	22	.290	.378	.491	.869
8	Rod Carew R. Carew	361	454	1,042	46	16	8	132	116	5	125	1,189	463	70	17	9	10	.346	.411	.444	.856
9	Roy Smalley R. Smalley	300	572	1,202	57	3	34	151	150	2	164	1,386	465	94	17	14	10	.250	.330	.387	.717
10	Chuck Knoblauch C. Knoblauch	295	415	953	53	11	14	101	109	10	110	1,080	412	78	2	6	10	.310	.384	.432	.816
11	Jorge Polanco J. Polanco	271	518	1,008	56	4	31	149	49	9	195	1,085	428	91	5	14	0	.269	.305	.425	.729
12	Greg Gagne G. Gagne	267	497	1,022	63	19	20	101	62	4	205	1,116	428	102	19	9	1	.261	.304	.419	.722
13	Tom Brunansky T. Brunansky	266	453	1,009	55	6	60	163	135	3	136	1,161	513	121	0	14	12	.264	.348	.508	.856
14	Cristian Guzman C. Guzman	265	445	974	57	17	16	86	38	6	142	1,034	404	90	9	7	2	.272	.301	.415	.716
15	Brian Dozier B. Dozier	264	452	953	68	8	48	126	112	8	201	1,082	492	124	2	6	9	.277	.356	.516	.872
16	John Castino J. Castino	264	358	860	35	14	15	100	59	1	81	942	372	64	19	3	4	.307	.351	.433	.784
17	Mickey Hatcher M. Hatcher	253	351	846	49	5	15	106	46	1	46	906	357	69	2	11	5	.299	.332	.422	.754
18	Dan Ford D. Ford	252	347	860	51	13	28	116	61	9	128	935	413	92	3	2	10	.293	.345	.480	.826
19	Byron Buxton B. Buxton	219	425	840	54	8	42	104	79	5	260	936	415	104	4	8	6	.261	.325	.494	.819
20	Denard Span D. Span	215	344	734	28	14	7	92	90	8	116	849	292	49	13	4	0	.293	.374	.398	.772
21	Brian Harper B. Harper	215	328	696	52	3	16	98	44	7	41	761	321	71	1	13	16	.309	.350	.461	.811
22	Dan Gladden D. Gladden	215	304	760	40	7	14	80	59	5	81	834	311	61	2	8	3	.283	.335	.409	.745
23	Max Kepler M. Kepler	214	606	968	50	3	27	121	84	17	229	1,081	351	80	2	10	0	.221	.292	.363	.655
24	Ron Coomer R. Coomer	213	352	691	45	3	31	119	52	2	80	753	357	79	0	8	7	.308	.355	.517	.871
25	Butch Wynegar B. Wynegar	211	440	845	41	1	11	85	115	4	104	982	287	53	10	8	9	.250	.340	.340	.679