The Colorado Rockies have the lowest run differential by a team this season, with a differential of -196 runs.

Interpreted as:

worst MLB team run differential this regular season

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Rockies	-196	2025	75	.227	17	58	2,506	261	568	118	25	73	257	203	29	732	35	18	2,761	955	216	8	15	5	55	.227	.291	.381	.672
2	Athletics	-126	2025	77	.403	31	46	2,636	328	665	130	8	97	317	250	18	632	42	10	2,922	1,102	235	4	14	5	70	.252	.320	.418	.738
3	Marlins	-89	2025	73	.397	29	44	2,496	295	626	117	10	64	283	215	18	588	56	24	2,763	955	191	14	20	5	44	.251	.312	.383	.695
4	Orioles	-76	2025	74	.432	32	42	2,464	297	592	107	9	87	278	209	32	653	53	16	2,728	978	203	2	21	6	60	.240	.306	.397	.702
5	White Sox	-75	2025	75	.307	23	52	2,458	260	546	114	5	58	249	243	14	652	55	15	2,746	844	177	11	20	4	42	.222	.294	.343	.637
6	Nationals	-70	2025	75	.413	31	44	2,491	310	595	122	10	72	294	210	37	556	63	26	2,765	953	204	12	15	3	48	.239	.306	.383	.688
7	Pirates	-61	2025	76	.395	30	46	2,506	245	564	93	13	53	235	253	28	661	69	22	2,809	842	159	7	15	11	67	.225	.302	.336	.638
8	Angels	-60	2025	74	.486	36	38	2,461	303	553	96	8	105	292	186	36	719	35	14	2,707	980	209	7	17	9	43	.225	.287	.398	.685
9	Guardians	-24	2025	73	.507	37	36	2,377	278	548	101	7	74	263	225	27	598	59	17	2,663	885	182	9	25	10	46	.231	.301	.372	.674
10	Royals	-17	2025	75	.493	37	38	2,520	253	624	121	15	53	249	178	24	511	58	25	2,762	934	189	17	23	12	38	.248	.301	.371	.672
11	Diamondbacks	-9	2025	74	.500	37	37	2,501	375	630	132	16	104	367	271	35	579	55	17	2,847	1,106	252	12	28	9	49	.252	.330	.442	.772
12	Blue Jays	-8	2025	74	.541	40	34	2,493	320	637	129	3	77	308	239	29	506	38	12	2,801	1,003	209	16	24	13	57	.256	.325	.402	.727
13	Mariners	7	2025	74	.514	38	36	2,524	326	613	102	4	95	315	268	37	660	76	20	2,855	1,008	201	11	15	7	43	.243	.323	.399	.722
14	Twins	11	2025	74	.500	37	37	2,487	314	605	119	8	81	302	219	47	616	36	14	2,769	983	208	1	15	4	48	.243	.315	.395	.710
15	Rangers	16	2025	75	.480	36	39	2,456	270	560	104	7	76	261	204	28	609	62	18	2,710	906	187	3	19	6	37	.228	.293	.369	.661
16	Red Sox	18	2025	76	.513	39	37	2,621	358	651	141	11	92	343	260	36	704	63	15	2,938	1,090	244	6	15	15	42	.248	.323	.416	.739
17	Brewers	20	2025	75	.533	40	35	2,491	327	593	104	8	69	303	255	31	620	92	23	2,811	920	181	16	18	9	37	.238	.314	.369	.684
18	Padres	21	2025	74	.541	40	34	2,468	312	614	111	11	63	288	230	21	527	55	14	2,762	936	185	18	25	8	50	.249	.315	.379	.694
19	Braves	24	2025	73	.466	34	39	2,471	307	605	101	7	78	294	256	22	620	37	12	2,773	954	186	7	17	8	47	.245	.319	.386	.705
20	Cardinals	31	2025	75	.533	40	35	2,556	353	657	130	4	72	335	241	40	589	41	14	2,867	1,011	206	9	21	11	55	.257	.328	.396	.724
21	Phillies	34	2025	75	.600	45	30	2,551	348	653	117	11	80	332	264	29	584	64	15	2,867	1,032	208	7	16	9	45	.256	.331	.405	.735
22	Reds	37	2025	75	.520	39	36	2,516	350	625	125	7	84	337	260	23	653	61	23	2,823	1,016	216	6	18	7	44	.248	.322	.404	.726
23	Giants	43	2025	75	.560	42	33	2,462	315	572	111	12	71	300	269	28	633	42	16	2,795	920	194	14	22	6	49	.232	.312	.374	.686
24	Astros	52	2025	75	.573	43	32	2,514	321	649	111	7	79	307	218	35	575	43	16	2,796	1,011	197	9	20	6	66	.258	.324	.402	.726
25	Rays	65	2025	75	.547	41	34	2,518	346	638	118	6	78	329	233	25	635	101	23	2,803	1,002	202	7	20	3	49	.253	.320	.398	.718