The Philadelphia Phillies have the lowest run differential by a team with 4+ games played, with a differential of -5,699 runs.

Interpreted as:

worst run differential after 4 or more games

	TEAM	DIFF	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Phillies	-5,699	21,704	.474	10,243	11,346	742,648	96,383	193,385	33,428	6,679	14,202	86,604	67,779	5,418	105,414	14,971	2,916	830,780	282,777	54,309	11,917	3,018	3,739	9,867	.260	.326	.381	.706
2	Orioles	-5,455	19,369	.475	9,139	10,120	657,938	83,629	169,773	29,343	4,912	14,439	77,321	63,312	4,479	98,426	10,560	2,785	739,365	252,257	48,694	10,532	3,104	2,576	10,848	.258	.326	.383	.709
3	Twins	-3,220	19,378	.482	9,289	9,980	661,034	85,194	173,346	29,764	6,334	12,022	78,434	62,375	5,166	94,533	12,017	3,081	741,932	251,844	48,120	10,190	3,167	2,664	10,978	.262	.329	.381	.710
4	Athletics	-3,118	19,332	.486	9,352	9,893	655,276	85,316	168,667	29,213	5,333	14,150	78,618	64,543	4,734	99,109	12,111	3,207	738,339	250,996	48,696	10,682	3,104	2,272	10,629	.257	.327	.383	.710
5	Padres	-2,853	8,900	.467	4,158	4,740	300,876	36,079	75,028	13,275	1,761	7,270	33,926	28,638	2,126	59,524	6,009	2,605	337,602	113,635	22,306	3,712	2,250	2,687	6,504	.249	.317	.378	.695
6	Marlins	-2,232	5,066	.459	2,325	2,741	172,211	21,321	43,877	8,346	984	4,615	20,215	15,573	1,835	38,336	3,258	1,296	192,616	68,036	13,945	1,719	1,278	1,203	3,807	.255	.321	.395	.716
7	Royals	-2,162	8,890	.477	4,238	4,650	304,072	38,861	79,850	14,928	2,291	7,005	36,676	26,013	2,464	52,186	7,097	2,900	337,594	120,375	24,224	2,372	2,673	1,868	6,782	.263	.323	.396	.719
8	Rangers	-2,094	10,183	.476	4,845	5,332	347,592	45,795	89,630	15,972	1,892	10,204	43,271	32,912	2,702	65,253	5,953	2,849	389,002	139,998	28,068	2,963	2,833	2,251	7,796	.258	.324	.403	.727
9	Rockies	-1,923	5,076	.459	2,330	2,746	174,321	25,088	47,080	9,296	1,310	5,732	23,857	16,005	1,582	37,801	3,060	1,370	195,271	76,192	16,338	2,005	1,358	1,209	3,868	.270	.335	.437	.772
10	Colonels	-1,890	2,355	.429	993	1,320	82,256	12,464	21,505	2,816	1,292	436	8,508	6,080	757	3,638	3,474		89,787	28,213	4,544	609				.261	.319	.343	.662
11	Senators	-1,865	1,265	.366	454	788	43,645	6,912	11,886	1,615	787	357	5,764	4,269	575	3,492	1,975		48,963	16,146	2,759	474				.272	.345	.370	.715
12	Mariners	-1,647	7,606	.477	3,629	3,975	259,453	33,768	66,659	12,425	1,259	7,738	32,080	24,600	2,357	49,805	5,029	2,172	290,433	104,816	21,422	1,947	2,076	1,664	5,684	.257	.325	.404	.728
13	Nationals	-1,470	8,894	.483	4,291	4,599	300,803	37,264	76,323	14,729	1,790	7,613	35,024	28,276	2,630	57,237	6,554	2,779	337,877	117,471	24,132	3,880	2,288	2,882	6,508	.254	.321	.391	.712
14	Nationals	-1,080	514	.326	163	337	17,337	2,160	3,944	533	220	125	1,647	1,246	127		1,040		18,710	5,292	878					.227	.284	.305	.589
15	Brewers	-813	8,899	.488	4,337	4,558	302,065	39,551	77,331	14,414	1,756	8,713	37,471	29,077	2,714	58,991	5,996	2,734	339,438	121,396	24,883	3,165	2,417	2,160	6,612	.256	.325	.402	.726
16	Orioles	-802	944	.437	403	519	32,654	4,964	7,699	1,083	504	136	2,635	2,289	208		1,451		35,293	10,198	1,723					.236	.293	.312	.605
17	Mets	-772	10,028	.484	4,850	5,170	339,263	41,369	84,768	15,146	1,818	8,584	38,954	32,443	2,868	65,022	5,893	2,737	381,187	129,302	25,548	3,989	2,624	3,143	7,465	.250	.318	.381	.699
18	Angels	-714	10,194	.495	5,046	5,145	345,859	44,108	88,483	15,300	1,811	9,228	41,505	32,337	2,827	62,824	6,049	3,101	387,336	135,089	26,339	3,539	2,774	2,484	7,879	.256	.322	.391	.713
19	Spiders	-672	1,802	.469	827	938	63,232	10,057	17,006	2,308	961	292	8,238	5,871	580	3,144	2,800		70,233	22,112	3,561	550				.269	.337	.350	.686
20	Reds	-638	348	.365	125	217	12,768	1,643	3,191	408	157	30		318					13,086	4,003	595					.250		.314
21	Hoosiers	-540	398	.370	146	249	13,870	2,050	3,536	570	138	129	1,577	913	131		936		14,914	4,769	837					.255	.307	.344	.651
22	Cowboys	-496	271	.364	98	171	9,535	1,431	2,256	304	137	37	1,052	718	123		729		10,376	2,945	478					.237	.298	.309	.607
23	Rays	-444	4,326	.490	2,120	2,206	147,073	19,225	37,322	7,439	850	4,506	18,290	13,989	1,679	33,476	3,230	1,228	164,637	59,979	12,795	738	1,158	685	3,030	.254	.323	.408	.731
24	Bisons	-406	134	.273	36	96	4,795	793	1,249	180	64	20	630	541	96	367	160		5,432	1,617	264					.260	.347	.337	.684
25	Trojans	-388	330	.412	134	191	11,951	1,542	2,929	456	151	26		414					12,365	3,765	633					.245		.315