Since April 22, 2025, the Colorado Rockies have the lowest run differential by a team, with a differential of -147 runs.

	TEAM	DIFF	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Rockies	-147	44	.182	8	36	1,457	136	321	68	13	40	135	111	9	390	20	11	1,591	535	121	5	9	2	33	.220	.278	.367	.645
2	Athletics	-97	45	.356	16	29	1,550	194	405	82	4	50	189	155	14	394	31	4	1,731	645	136	3	9	5	42	.261	.332	.416	.748
3	Orioles	-69	43	.395	17	26	1,447	148	348	63	6	39	139	121	17	386	36	9	1,602	540	108	2	15	3	32	.240	.304	.373	.677
4	Marlins	-65	41	.341	14	27	1,380	156	333	67	6	36	152	118	7	308	29	14	1,518	520	109	6	7	2	30	.241	.303	.377	.680
5	Angels	-46	43	.442	19	24	1,426	182	322	65	5	60	173	113	16	426	19	9	1,569	577	130	5	9	2	22	.226	.288	.405	.693
6	Pirates	-36	43	.419	18	25	1,421	130	338	53	7	30	124	143	17	370	33	12	1,591	495	90	4	6	5	42	.238	.314	.348	.662
7	Diamondbacks	-35	43	.419	18	25	1,465	203	370	77	9	61	199	140	21	324	31	11	1,642	648	147	3	13	3	34	.253	.324	.442	.766
8	Nationals	-31	43	.488	21	22	1,434	182	349	81	8	40	174	106	27	326	32	15	1,581	566	129	5	9	2	28	.243	.306	.395	.701
9	White Sox	-23	44	.386	17	27	1,436	163	339	75	2	35	155	150	8	364	31	9	1,615	523	112	8	13	1	28	.236	.309	.364	.673
10	Guardians	-17	42	.500	21	21	1,374	158	317	61	4	38	148	129	15	351	37	10	1,534	500	103	7	9	7	21	.231	.302	.364	.666
11	Padres	-15	41	.512	21	20	1,368	158	316	51	7	33	147	115	11	307	24	9	1,516	480	91	10	12	2	25	.231	.293	.351	.644
12	Mariners	-5	42	.500	21	21	1,447	184	357	55	2	51	181	137	19	372	31	8	1,617	569	108	5	9	2	27	.247	.318	.393	.711
13	Reds	9	43	.512	22	21	1,440	181	352	76	6	45	174	147	10	382	39	13	1,611	575	127	3	11	5	23	.244	.317	.399	.716
14	Blue Jays	9	42	.548	23	19	1,414	190	356	69	2	53	185	143	10	281	20	5	1,584	588	124	8	9	9	28	.252	.323	.416	.739
15	Braves	12	42	.429	18	24	1,447	175	357	64	5	39	168	144	15	346	23	10	1,619	548	108	4	9	7	22	.247	.320	.379	.698
16	Giants	12	43	.535	23	20	1,393	155	321	54	4	35	147	136	17	346	23	9	1,567	488	93	8	13	3	34	.230	.304	.350	.654
17	Phillies	14	42	.571	24	18	1,439	190	359	63	5	47	181	131	15	323	33	7	1,599	573	115	3	11	2	21	.249	.316	.398	.715
18	Royals	15	43	.581	25	18	1,471	159	404	76	10	33	156	92	13	278	38	15	1,605	599	119	12	17	7	26	.275	.320	.407	.727
19	Brewers	15	43	.535	23	20	1,436	178	338	61	1	36	169	157	18	343	51	13	1,628	509	98	8	9	5	20	.235	.317	.354	.671
20	Rangers	16	44	.409	18	26	1,442	154	320	48	4	44	150	122	14	373	38	11	1,593	508	96	3	12	2	17	.222	.287	.352	.639
21	Astros	18	43	.581	25	18	1,443	177	379	61	5	48	172	110	20	313	18	7	1,586	594	114	4	9	1	37	.263	.322	.412	.733
22	Red Sox	22	43	.442	19	24	1,512	222	394	81	7	59	214	140	21	392	32	9	1,687	666	147	5	9	5	20	.261	.330	.440	.770
23	Cardinals	29	42	.643	27	15	1,396	192	356	73	3	36	182	133	24	317	18	9	1,574	543	112	5	16	4	28	.255	.327	.389	.716
24	Rays	40	43	.605	26	17	1,451	193	350	72	0	49	183	121	14	376	63	12	1,600	569	121	3	11	1	21	.241	.304	.392	.696
25	Twins	57	43	.651	28	15	1,460	201	375	64	4	51	193	136	28	353	21	8	1,636	600	119	1	11	3	31	.257	.330	.411	.741