Since April 23, 2025, the Colorado Rockies have the lowest run differential by a team, with a differential of -146 runs.

	TEAM	DIFF	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Rockies	-146	43	.186	8	35	1,422	133	316	67	13	40	132	105	9	383	20	11	1,549	529	120	4	9	2	32	.222	.278	.372	.650
2	Athletics	-94	44	.364	16	28	1,512	189	394	81	4	46	184	151	14	388	29	4	1,689	621	131	3	9	5	42	.261	.332	.411	.742
3	Marlins	-66	40	.325	13	27	1,349	152	324	63	6	36	149	113	7	302	28	13	1,482	507	105	6	7	1	30	.240	.301	.376	.677
4	Orioles	-62	42	.405	17	25	1,419	148	347	63	6	39	139	117	17	380	36	9	1,570	539	108	2	15	3	32	.245	.307	.380	.687
5	Pirates	-42	42	.405	17	25	1,379	121	320	51	7	29	115	136	17	364	33	12	1,542	472	87	4	6	5	39	.232	.308	.342	.650
6	Angels	-40	42	.452	19	23	1,395	179	317	63	5	59	170	111	16	414	19	9	1,535	567	127	5	8	2	22	.227	.290	.406	.697
7	Diamondbacks	-39	42	.405	17	25	1,437	198	363	75	9	59	194	137	20	321	30	10	1,609	633	143	3	12	3	33	.253	.324	.441	.764
8	Nationals	-38	42	.476	20	22	1,397	175	335	74	7	38	168	106	27	319	32	15	1,544	537	119	5	9	2	27	.240	.304	.384	.688
9	White Sox	-21	43	.395	17	26	1,402	161	329	73	2	35	153	147	8	355	31	9	1,577	511	110	8	12	1	26	.235	.308	.364	.673
10	Guardians	-18	41	.488	20	21	1,343	155	311	60	4	38	146	127	15	345	33	10	1,501	493	102	7	9	7	21	.232	.303	.367	.670
11	Padres	-17	40	.500	20	20	1,335	156	310	51	7	32	145	113	10	295	24	9	1,480	471	90	10	12	2	25	.232	.295	.353	.647
12	Mariners	0	41	.512	21	20	1,416	181	351	53	2	50	178	131	17	367	31	7	1,578	558	105	5	9	2	26	.248	.317	.394	.711
13	Brewers	7	42	.524	22	20	1,396	167	325	59	1	34	159	153	17	337	51	13	1,583	488	94	8	9	5	19	.233	.314	.350	.664
14	Reds	10	42	.524	22	20	1,407	178	345	74	6	44	171	144	10	371	35	13	1,574	563	124	3	10	5	23	.245	.318	.400	.718
15	Rangers	13	43	.395	17	26	1,406	146	310	47	4	40	142	116	14	366	37	11	1,550	485	91	3	11	2	17	.220	.284	.345	.629
16	Blue Jays	13	41	.561	23	18	1,385	189	354	69	2	52	184	141	10	274	20	5	1,553	583	123	8	9	9	28	.256	.327	.421	.748
17	Royals	14	42	.571	24	18	1,435	155	395	75	9	32	152	89	13	273	36	14	1,565	584	116	12	16	5	25	.275	.320	.407	.727
18	Astros	14	42	.571	24	18	1,411	172	369	59	5	47	167	108	18	305	18	7	1,549	579	111	4	8	1	37	.262	.320	.410	.731
19	Red Sox	17	42	.429	18	24	1,478	214	383	78	6	58	207	133	21	383	28	9	1,645	647	142	5	8	5	20	.259	.327	.438	.765
20	Braves	18	41	.439	18	23	1,412	171	349	62	5	37	164	138	15	341	23	10	1,578	532	104	4	9	7	22	.247	.319	.377	.696
21	Phillies	18	41	.585	24	17	1,406	189	351	62	5	47	180	127	15	315	33	7	1,562	564	114	3	11	2	20	.250	.316	.401	.717
22	Giants	20	42	.548	23	19	1,360	152	310	52	4	35	144	132	16	342	23	9	1,528	475	91	8	12	3	31	.228	.301	.349	.651
23	Cardinals	23	41	.634	26	15	1,358	182	344	70	3	35	173	126	23	309	17	9	1,527	525	108	5	15	2	28	.253	.324	.387	.711
24	Rays	44	42	.619	26	16	1,421	192	344	70	0	49	182	119	13	370	62	12	1,567	561	119	3	11	1	18	.242	.304	.395	.699
25	Mets	53	42	.595	25	17	1,423	204	367	62	7	60	200	163	32	332	37	5	1,637	623	129	3	16	10	40	.258	.344	.438	.782