The Kansas City Royals had the lowest run differential by a team in 2006, with a differential of -214 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Royals	-214	2006	162	.383	62	100	5,589	757	1,515	335	37	124	718	474	64	1,040	65	34	6,227	2,296	496	52	48	32	130	.271	.332	.411	.743
2	Devil Rays	-167	2006	162	.377	61	101	5,474	689	1,395	267	33	190	650	441	47	1,106	134	52	6,040	2,298	490	35	43	23	101	.255	.314	.420	.733
3	Orioles	-131	2006	162	.432	70	92	5,610	768	1,556	288	20	164	727	474	73	878	121	32	6,238	2,376	472	40	41	35	145	.277	.339	.424	.763
4	Nationals	-126	2006	162	.438	71	91	5,495	746	1,437	322	22	164	695	594	69	1,156	123	62	6,283	2,295	508	76	49	66	118	.262	.338	.418	.756
5	Cubs	-118	2006	162	.407	66	96	5,587	716	1,496	271	46	166	677	395	43	928	121	49	6,146	2,357	483	84	37	24	135	.268	.319	.422	.741
6	Pirates	-106	2006	162	.414	67	95	5,558	691	1,462	286	17	141	656	459	89	1,200	68	23	6,217	2,205	444	62	49	49	153	.263	.327	.397	.723
7	Brewers	-103	2006	162	.463	75	87	5,433	730	1,400	301	20	180	695	502	82	1,233	71	37	6,128	2,281	501	58	53	48	133	.258	.327	.420	.747
8	Reds	-52	2006	162	.494	80	82	5,515	749	1,419	291	12	217	718	614	59	1,192	124	33	6,292	2,385	520	66	38	52	122	.257	.336	.432	.768
9	Giants	-44	2006	161	.472	76	85	5,472	746	1,418	297	52	163	711	494	53	891	58	25	6,136	2,308	512	80	37	76	136	.259	.324	.422	.746
10	Mariners	-36	2006	162	.481	78	84	5,670	756	1,540	266	42	172	703	404	63	974	106	37	6,213	2,406	480	38	38	49	117	.272	.325	.424	.749
11	Diamondbacks	-15	2006	162	.469	76	86	5,645	773	1,506	331	38	160	743	504	67	965	76	30	6,330	2,393	529	61	53	47	136	.267	.331	.424	.755
12	Marlins	-14	2006	162	.481	78	84	5,502	758	1,454	309	42	182	713	497	74	1,249	110	58	6,191	2,393	533	76	42	55	109	.264	.331	.435	.766
13	Red Sox	-5	2006	162	.531	86	76	5,619	820	1,510	327	16	192	777	672	66	1,056	51	23	6,435	2,445	535	22	56	56	136	.269	.351	.435	.786
14	Rockies	1	2006	162	.469	76	86	5,562	813	1,504	325	54	157	761	561	60	1,108	85	50	6,347	2,408	536	119	45	64	119	.270	.341	.433	.774
15	Astros	16	2006	162	.506	82	80	5,521	735	1,407	275	27	174	708	585	73	1,076	79	36	6,325	2,258	476	100	46	54	122	.255	.332	.409	.741
16	Cardinals	19	2006	161	.516	83	78	5,522	781	1,484	292	27	184	745	531	61	922	59	32	6,225	2,382	503	71	40	70	129	.269	.337	.431	.769
17	Angels	34	2006	162	.549	89	73	5,609	766	1,539	309	29	159	737	486	42	914	148	57	6,221	2,383	497	31	53	49	126	.274	.334	.425	.759
18	Braves	44	2006	162	.488	79	83	5,583	849	1,510	312	26	222	818	526	52	1,169	52	35	6,283	2,540	560	78	44	48	131	.270	.337	.455	.791
19	Athletics	44	2006	162	.574	93	69	5,500	771	1,429	266	22	175	735	650	50	976	61	20	6,281	2,264	463	25	56	28	170	.260	.340	.412	.752
20	Rangers	51	2006	162	.494	80	82	5,659	835	1,571	357	23	183	799	505	40	1,061	53	24	6,272	2,523	563	18	50	35	148	.278	.338	.446	.784
21	Padres	52	2006	162	.543	88	74	5,576	731	1,465	298	38	161	698	564	40	1,104	123	31	6,286	2,322	497	59	47	37	127	.263	.332	.416	.749
22	Phillies	53	2006	162	.525	85	77	5,687	865	1,518	294	41	216	823	626	95	1,203	92	25	6,509	2,542	551	57	44	67	115	.267	.347	.447	.794
23	Blue Jays	55	2006	162	.537	87	75	5,596	809	1,591	348	27	199	778	514	63	906	65	33	6,241	2,590	574	16	52	31	166	.284	.348	.463	.811
24	Dodgers	69	2006	162	.543	88	74	5,628	820	1,552	307	58	153	787	601	51	959	128	49	6,394	2,434	518	66	48	61	140	.276	.348	.432	.781
25	White Sox	74	2006	162	.556	90	72	5,657	868	1,586	291	20	236	839	502	58	1,056	93	48	6,318	2,625	547	44	57	33	118	.280	.342	.464	.806