The Houston Astros had the lowest run differential by a team in 2012, with a differential of -211 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Astros	-211	2012	162	.340	55	107	5,407	583	1,276	238	28	146	545	463	58	1,365	105	46	6,012	2,008	412	54	30	19	114	.236	.302	.371	.673
2	Indians	-178	2012	162	.420	68	94	5,525	667	1,385	266	24	136	635	555	59	1,087	110	44	6,195	2,107	426	17	39	28	141	.251	.324	.381	.705
3	Cubs	-146	2012	162	.377	61	101	5,411	613	1,297	265	36	137	570	447	43	1,235	94	45	5,967	2,045	438	42	24	29	125	.240	.302	.378	.680
4	Rockies	-132	2012	162	.395	64	98	5,577	758	1,526	306	52	166	716	450	36	1,213	100	40	6,176	2,434	524	74	39	34	132	.274	.330	.436	.766
5	Twins	-131	2012	162	.407	66	96	5,562	701	1,448	270	30	131	666	505	53	1,069	135	37	6,209	2,171	431	33	56	28	149	.260	.325	.390	.715
6	Marlins	-115	2012	162	.426	69	93	5,437	609	1,327	261	39	137	576	484	35	1,228	149	41	6,056	2,077	437	60	40	46	114	.244	.308	.382	.690
7	Red Sox	-72	2012	162	.426	69	93	5,604	734	1,459	339	16	165	695	428	45	1,197	97	31	6,166	2,325	520	34	55	27	105	.260	.315	.415	.730
8	Royals	-70	2012	162	.444	72	90	5,636	676	1,492	295	37	131	643	404	42	1,032	132	38	6,149	2,254	463	26	41	35	130	.265	.317	.400	.716
9	Blue Jays	-68	2012	162	.451	73	89	5,487	716	1,346	247	22	198	677	473	55	1,251	123	41	6,093	2,231	467	33	45	29	109	.245	.309	.407	.716
10	Mets	-59	2012	162	.457	74	88	5,450	650	1,357	286	21	139	625	503	42	1,250	79	38	6,089	2,102	446	64	30	43	118	.249	.316	.386	.701
11	Padres	-59	2012	162	.469	76	86	5,422	651	1,339	272	43	121	610	539	54	1,238	155	46	6,112	2,060	436	63	34	36	100	.247	.319	.380	.699
12	Mariners	-32	2012	162	.463	75	87	5,494	619	1,285	241	27	149	584	466	30	1,259	104	35	6,057	2,027	417	32	35	21	95	.234	.296	.369	.665
13	Pirates	-23	2012	162	.488	79	83	5,412	651	1,313	241	37	170	620	444	51	1,354	73	52	6,014	2,138	448	62	45	32	98	.243	.304	.395	.699
14	Phillies	4	2012	162	.500	81	81	5,544	684	1,414	271	28	158	659	454	63	1,094	116	23	6,172	2,215	457	72	39	41	114	.255	.317	.400	.716
15	Orioles	7	2012	162	.574	93	69	5,560	712	1,375	270	16	214	677	480	50	1,315	58	29	6,158	2,319	500	38	30	24	152	.247	.311	.417	.728
16	Dodgers	40	2012	162	.531	86	76	5,438	637	1,369	269	23	116	607	481	52	1,156	104	44	6,091	2,032	408	82	38	49	139	.252	.317	.374	.690
17	Brewers	43	2012	162	.512	83	79	5,557	776	1,442	300	39	202	741	466	90	1,240	158	39	6,224	2,426	541	76	35	35	111	.259	.325	.437	.762
18	Diamondbacks	46	2012	162	.500	81	81	5,462	734	1,416	307	33	165	710	539	41	1,266	93	51	6,148	2,284	505	61	45	47	108	.259	.328	.418	.746
19	Tigers	56	2012	162	.543	88	74	5,476	726	1,467	279	39	163	698	511	57	1,103	59	23	6,119	2,313	481	36	39	46	156	.268	.335	.422	.757
20	Angels	68	2012	162	.549	89	73	5,536	767	1,518	273	22	187	732	449	47	1,113	134	33	6,120	2,396	482	47	41	29	138	.274	.332	.433	.764
21	Giants	69	2012	162	.580	94	68	5,558	718	1,495	287	57	103	675	483	29	1,097	118	39	6,200	2,205	447	69	61	44	114	.269	.327	.397	.724
22	White Sox	72	2012	162	.525	85	77	5,518	748	1,409	228	29	211	726	461	65	1,203	109	43	6,111	2,328	468	31	36	24	112	.255	.318	.422	.740
23	Reds	81	2012	162	.599	97	65	5,477	669	1,377	296	30	172	636	481	47	1,266	87	27	6,115	2,249	498	73	37	54	100	.251	.315	.411	.726
24	Athletics	99	2012	162	.580	94	68	5,527	713	1,315	267	32	195	676	550	45	1,387	122	32	6,183	2,231	494	27	34	29	97	.238	.310	.404	.714
25	Braves	100	2012	162	.580	94	68	5,425	700	1,341	263	30	149	660	567	34	1,289	101	32	6,125	2,111	442	53	46	37	108	.247	.320	.389	.709