The Cleveland Spiders have the lowest run differential by a team in a season, with a differential of -723 runs in 1899.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Spiders	-723	1899	154	.130	20	134	5,279	529	1,333	142	50	12	454	289	65	280	127		5,690	1,611	204	57				.253	.299	.305	.605
2	Alleghenys	-638	1890	138	.169	23	113	4,739	597	1,088	160	43	20	426	408	66	460	208		5,213	1,394	223					.230	.300	.294	.594
3	Browns	-496	1897	133	.221	29	102	4,673	592	1,285	151	67	32	496	354	76	314	172		5,183	1,666	250	80				.275	.336	.357	.693
4	Colonels	-459	1889	140	.196	27	111	4,955	632	1,249	170	75	22	503	320	41	521	203		5,316	1,635	267					.252	.303	.330	.633
5	Quakers	-450	1883	99	.173	17	81	3,576	437	859	181	48	3	299	141		355			3,717	1,145	232					.240		.320
6	Rockies	-424	2025	162	.265	43	119	5,408	597	1,281	253	37	160	581	395	48	1,531	87	39	5,907	2,088	450	21	35	5	118	.237	.293	.386	.679
7	Bisons	-406	1890	134	.273	36	96	4,795	793	1,249	180	64	20	630	541	96	367	160		5,432	1,617	264					.260	.347	.337	.684
8	Colonels	-392	1895	133	.267	35	96	4,724	698	1,320	171	73	34	574	346	77	323	156		5,205	1,739	278	58				.279	.339	.368	.707
9	Spiders	-383	1887	133	.298	39	92	4,649	729	1,170	178	77	14	562	375	46	486	355		5,070	1,544	269					.252	.314	.332	.646
10	Cowboys	-378	1886	126	.248	30	91	4,236	494	967	177	48	19	370	269		608	96		4,505	1,297	244					.228		.306
11	Senators	-376	1891	139	.326	44	91	4,715	691	1,183	147	84	19	536	468	76	485	219		5,259	1,555	250					.251	.328	.330	.658
12	Browns	-358	1898	154	.260	39	111	5,214	571	1,290	149	55	13	470	383	84	405	104		5,798	1,588	217	117				.247	.309	.305	.614
13	Nationals	-347	1886	125	.233	28	92	4,082	445	856	135	51	23	331	265		582	143		4,347	1,162	209					.210		.285
14	Red Sox	-345	1932	154	.279	43	111	5,294	566	1,330	253	57	53	529	470	12	537	46	46	5,856	1,856	363	80				.251	.314	.351	.664
15	Athletics	-344	1915	154	.283	43	109	5,081	545	1,204	183	72	16	440	436	54	634	127	89	5,708	1,579	271	137				.237	.304	.311	.615
16	Colonels	-344	1896	134	.290	38	93	4,588	653	1,197	142	80	37	520	371	45	427	195		5,057	1,610	259	53				.261	.322	.351	.673
17	Reds	-341	1876	65	.138	9	56	2,372	238	555	51	12	4	132	41		136			2,413	642	67					.234		.271
18	Athletics	-339	2023	162	.309	50	112	5,311	585	1,187	225	21	171	563	498	85	1,496	149	31	5,958	1,967	417	28	36	12	125	.223	.298	.370	.669
19	Metropolitans	-339	1887	138	.331	44	89	4,821	754	1,197	193	66	21	549	439	50	456	305		5,310	1,585	280					.248	.318	.329	.646
20	Tigers	-337	2003	162	.265	43	119	5,466	591	1,312	201	39	153	553	443	47	1,099	98	63	6,070	2,050	393	65	49	24	114	.240	.300	.375	.675
21	Hoosiers	-337	1887	127	.294	37	89	4,368	628	1,080	162	70	33	488	300	44	379	334		4,712	1,481	265					.247	.302	.339	.641
22	Browns	-336	1896	131	.308	40	90	4,520	593	1,162	134	78	37	487	332	35	300	185		4,988	1,563	249	101				.257	.313	.346	.659
23	Tigers	-333	2019	161	.292	47	114	5,549	582	1,333	292	41	149	556	391	48	1,595	57	20	6,039	2,154	482	9	42	14	108	.240	.294	.388	.682
24	Athletics	-333	1954	156	.331	51	103	5,206	542	1,228	191	41	94	503	504	28	677	30	29	5,823	1,783	326	54	31		106	.236	.305	.342	.648
25	Mets	-331	1962	161	.250	40	120	5,492	617	1,318	166	40	139	573	616	32	991	59	48	6,242	1,981	345	58	44	29	122	.240	.318	.361	.679