Zack Greinke had a 12-10 record with an ERA of 3.52 and 158 strikeouts in 38 appearances against the Guardians in his career.
| NAME | DATE | TM | OPP | DEC | GS | ERA | SO | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Z. Greinke | 7/25/2004 | @ | L | 1 | 6.75 | 3 | 0 | 0 | 0 | 6.2 | 8 | 5 | 5 | 1 | 1 | 0 | 0 | 0 | 29 | 0 | ||
| 2 | | Z. Greinke | 7/31/2004 | vs | W | 1 | 5.40 | 4 | 0 | 0 | 0 | 5.0 | 7 | 3 | 3 | 1 | 2 | 1 | 0 | 0 | 22 | 0 | ||
| 3 | | Z. Greinke | 9/27/2004 | vs | 1 | 0.00 | 5 | 0 | 0 | 0 | 7.0 | 4 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 26 | 0 | |||
| 4 | | Z. Greinke | 4/18/2005 | vs | L | 1 | 9.00 | 3 | 0 | 0 | 0 | 5.0 | 7 | 5 | 5 | 2 | 1 | 1 | 0 | 0 | 25 | 1 | ||
| 5 | | Z. Greinke | 4/29/2005 | @ | L | 1 | 8.31 | 1 | 0 | 0 | 0 | 4.1 | 8 | 4 | 6 | 0 | 1 | 0 | 0 | 0 | 24 | 0 | ||
| 6 | | Z. Greinke | 7/19/2005 | @ | W | 1 | 0.00 | 4 | 0 | 0 | 0 | 7.0 | 4 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 25 | 0 | ||
| 7 | | Z. Greinke | 8/10/2005 | vs | L | 1 | 8.31 | 4 | 0 | 0 | 0 | 4.1 | 7 | 4 | 4 | 1 | 4 | 0 | 0 | 0 | 22 | 1 | ||
| 8 | | Z. Greinke | 9/25/2005 | vs | 1 | 0.00 | 6 | 0 | 0 | 0 | 7.0 | 5 | 0 | 3 | 1 | 1 | 0 | 0 | 0 | 27 | 0 | |||
| 9 | | Z. Greinke | 5/22/2007 | vs | W | 0 | 0.00 | 0 | 0 | 0 | 0 | 1.1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 1 | ||
| 10 | | Z. Greinke | 6/6/2007 | @ | 0 | 27.00 | 1 | 0 | 0 | 0 | 0.1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 3 | 0 | |||
| 11 | | Z. Greinke | 6/7/2007 | @ | 0 | 40.50 | 0 | 0 | 0 | 0 | 0.2 | 2 | 3 | 3 | 1 | 1 | 0 | 1 | 0 | 5 | 1 | |||
| 12 | | Z. Greinke | 7/13/2007 | @ | L | 0 | 27.00 | 0 | 0 | 0 | 0 | 0.1 | 2 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 4 | 0 | ||
| 13 | | Z. Greinke | 7/14/2007 | @ | 0 | 0.00 | 2 | 0 | 0 | 0 | 1.1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 5 | 0 | |||
| 14 | | Z. Greinke | 8/24/2007 | vs | 1 | 0.00 | 2 | 0 | 0 | 0 | 3.0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 9 | 0 | |||
| 15 | | Z. Greinke | 9/15/2007 | @ | L | 1 | 1.69 | 3 | 0 | 0 | 0 | 5.1 | 4 | 1 | 2 | 1 | 5 | 0 | 0 | 1 | 25 | 1 | ||
| 16 | | Z. Greinke | 8/21/2008 | @ | L | 1 | 1.80 | 4 | 0 | 0 | 0 | 5.0 | 6 | 1 | 5 | 1 | 1 | 0 | 0 | 0 | 24 | 0 | ||
| 17 | | Z. Greinke | 9/7/2008 | vs | L | 1 | 4.50 | 8 | 0 | 0 | 0 | 6.0 | 5 | 3 | 3 | 0 | 2 | 0 | 0 | 0 | 25 | 1 | ||
| 18 | | Z. Greinke | 9/13/2008 | @ | W | 1 | 4.50 | 5 | 0 | 0 | 0 | 6.0 | 9 | 3 | 3 | 0 | 1 | 0 | 0 | 0 | 27 | 0 | ||
| 19 | | Z. Greinke | 4/13/2009 | vs | W | 1 | 0.00 | 9 | 0 | 0 | 0 | 5.0 | 6 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 23 | 0 | ||
| 20 | | Z. Greinke | 5/21/2009 | vs | 1 | 3.00 | 8 | 0 | 0 | 0 | 6.0 | 8 | 2 | 2 | 0 | 2 | 0 | 0 | 0 | 27 | 0 | |||
| 21 | | Z. Greinke | 6/11/2009 | @ | 1 | 3.68 | 6 | 0 | 0 | 0 | 7.1 | 6 | 3 | 3 | 0 | 3 | 0 | 0 | 0 | 30 | 0 | |||
| 22 | | Z. Greinke | 8/25/2009 | vs | W | 1 | 2.25 | 15 | 0 | 0 | 0 | 8.0 | 5 | 2 | 2 | 1 | 1 | 0 | 0 | 0 | 29 | 0 | ||
| 23 | | Z. Greinke | 9/11/2009 | @ | 1 | 1.29 | 6 | 0 | 0 | 0 | 7.0 | 4 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 24 | 0 | |||
| 24 | | Z. Greinke | 5/13/2010 | vs | W | 1 | 4.50 | 8 | 0 | 0 | 0 | 6.0 | 8 | 3 | 3 | 0 | 2 | 0 | 0 | 0 | 28 | 1 | ||
| 25 | | Z. Greinke | 8/17/2010 | vs | W | 1 | 1.50 | 4 | 0 | 0 | 0 | 6.0 | 5 | 1 | 1 | 0 | 3 | 0 | 0 | 0 | 26 | 0 | ||
| Total | 33 | 3.52 | 158 | 0 | 0 | 0 | 196.2 | 206 | 77 | 88 | 16 | 53 | 3 | 2 | 2 | 831 | 13 | |||||||
KCR
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 Braves - y | 94 | 68 | .580 | |
 Phillies - w | 88 | 74 | .543 | 6.0 |
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| NL Central | W | L | PCT | GB |
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| NL West | W | L | PCT | GB |
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 Rays - y | 98 | 64 | .605 | |
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