Barry Bonds has the most career home runs + runs, with 2,989.

	NAME	HR+R	HR	R	G	AB	H	2B	3B	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS	WRC	WRAA	WOBA	WRC+	BRAA
1	Barry Bonds B. Bonds	2,989	762	2,227	2,986	9,847	2,935	601	77	1,996	2,558	106	1,539	514	141	12,606	5,976	1,440	4	91	688	165	.298	.444	.607	1.051	2663	1,143.3	.435	172	1,142
2	Hank Aaron H. Aaron	2,929	755	2,174	3,298	12,364	3,771	624	98	2,297	1,402	32	1,383	240	73	13,940	6,856	1,477	21	121	293	328	.305	.374	.555	.928	2453	936.4	.403	153	858.5
3	Babe Ruth B. Ruth	2,888	714	2,174	2,503	8,399	2,873	506	136	2,214	2,062	43	1,330	123		10,617	5,793	1,356	113				.342	.474	.690	1.164	2727	1,436.8	.513	197	1,369.6
4	Willie Mays W. Mays	2,722	660	2,062	2,992	10,881	3,283	523	140	1,903	1,464	44	1,526	338	103	12,493	6,066	1,323	13	91	192	251	.302	.384	.557	.941	2266	894.8	.409	154	802.7
5	Alex Rodriguez A. Rodriguez	2,717	696	2,021	2,784	10,566	3,115	548	31	2,086	1,338	176	2,287	329	76	12,207	5,813	1,275	16	111	97	261	.295	.380	.550	.930	2178	690.1	.395	141	629.5
6	Albert Pujols A. Pujols	2,617	703	1,914	3,080	11,421	3,384	686	16	2,218	1,373	123	1,404	117	43	13,041	6,211	1,405	1	123	316	426	.296	.374	.544	.918	2233	685	.385	141	673
7	Rickey Henderson R. Henderson	2,592	297	2,295	3,081	10,961	3,055	510	66	1,115	2,190	98	1,694	1,406	335	13,346	4,588	873	30	67	61	172	.279	.401	.419	.820	2074	509.6	.372	132	507.9
8	Stan Musial S. Musial	2,424	475	1,949	3,026	10,972	3,630	725	177	1,951	1,599	53	696	78	31	12,712	6,134	1,377	35	53	127	243	.331	.417	.559	.976	2474	1,032.5	.435	158	896.7
9	Frank Robinson F. Robinson	2,415	586	1,829	2,808	10,006	2,943	528	72	1,812	1,420	198	1,532	204	77	11,743	5,373	1,186	17	102	218	270	.294	.389	.537	.926	2083	807.2	.404	153	717.1
10	Lou Gehrig L. Gehrig	2,381	493	1,888	2,164	8,001	2,721	534	163	1,995	1,508	45	790	102		9,660	5,060	1,190	106			2	.340	.447	.632	1.080	2265	1,046.8	.477	173	980
11	Mel Ott M. Ott	2,370	511	1,859	2,730	9,456	2,876	488	72	1,860	1,708	64	896	89		11,337	5,041	1,071	109			38	.304	.414	.533	.947	2204	826.4	.430	156	794.2
12	Ty Cobb T. Cobb	2,361	117	2,244	3,034	11,434	4,189	724	295	1,933	1,249	94	681	897		13,068	5,854	1,136	291				.366	.433	.512	.945	2534	1,093.6	.445	165	975.1
13	Pete Rose P. Rose	2,325	160	2,165	3,562	14,053	4,256	746	135	1,314	1,566	107	1,143	198	149	15,861	5,752	1,041	56	79	167	247	.303	.375	.409	.784	2190	480.1	.354	121	368.7
14	Ted Williams T. Williams	2,319	521	1,798	2,292	7,706	2,654	525	71	1,839	2,021	39	709	24	4	9,791	4,884	1,117	5	20	86	197	.344	.482	.634	1.116	2349	1,219.7	.493	188	1,067
15	Ken Griffey Jr. K. Griffey Jr.	2,292	630	1,662	2,671	9,801	2,781	524	38	1,836	1,312	81	1,779	184	69	11,304	5,271	1,192	8	102	246	199	.284	.370	.538	.907	1892	521.1	.384	132	453.4
16	Jimmie Foxx J. Foxx	2,285	534	1,751	2,317	8,134	2,646	458	125	1,922	1,452	13	1,311	87		9,670	4,956	1,117	71			69	.325	.428	.609	1.038	2135	934.1	.460	158	780.8
17	Carl Yastrzemski C. Yastrzemski	2,268	452	1,816	3,308	11,988	3,419	646	59	1,844	1,845	40	1,393	168	116	13,991	5,539	1,157	13	105	190	323	.285	.379	.462	.841	2155	643.2	.375	130	469.8
18	Rafael Palmeiro R. Palmeiro	2,232	569	1,663	2,831	10,472	3,020	585	38	1,835	1,353	87	1,348	97	40	12,046	5,388	1,192	15	119	172	232	.288	.371	.515	.885	1975	522.8	.380	130	453.5
19	Mickey Mantle M. Mantle	2,212	536	1,676	2,401	8,102	2,415	344	72	1,509	1,733	13	1,710	153	38	9,909	4,511	952	14	47	126	113	.298	.421	.557	.977	1941	840	.428	170	821.8
20	Jim Thome J. Thome	2,195	612	1,583	2,543	8,422	2,328	451	26	1,699	1,747	69	2,548	19	20	10,313	4,667	1,089	1	74	173	165	.276	.402	.554	.956	1925	653.9	.406	145	589.5
21	Derek Jeter D. Jeter	2,183	260	1,923	2,747	11,195	3,465	544	66	1,311	1,082	170	1,840	358	97	12,602	4,921	870	97	58	39	287	.310	.377	.440	.817	1877	346.6	.360	119	305.9
22	Gary Sheffield G. Sheffield	2,145	509	1,636	2,576	9,217	2,689	467	27	1,676	1,475	135	1,171	253	104	10,947	4,737	1,003	9	111	130	235	.292	.393	.514	.907	1907	574.5	.391	141	567.2
23	Craig Biggio C. Biggio	2,135	291	1,844	2,850	10,876	3,060	668	55	1,175	1,160	285	1,753	414	124	12,503	4,711	1,014	101	81	68	150	.281	.363	.433	.796	1768	248.9	.352	115	238.9
24	Dave Winfield D. Winfield	2,134	465	1,669	2,973	11,003	3,110	540	88	1,833	1,216	25	1,686	223	96	12,358	5,221	1,093	19	95	172	319	.283	.353	.475	.827	1811	416.2	.364	128	400.6
25	Eddie Murray E. Murray	2,131	504	1,627	3,026	11,336	3,255	560	35	1,917	1,333	18	1,516	110	43	12,817	5,397	1,099	2	128	222	315	.287	.359	.476	.836	1904	432.6	.365	127	406.9