Between the 2004 and 2008 seasons, Johan Santana fanned the most hitters, with 1,189 strikeouts.

	NAME	SO	G	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Johan Santana J. Santana	1,189	168	86	39	.688	168	2.82	9	6	0	1146.2	911	359	388	126	261	22	0	6	4,556	35	9.33	2.05	4.56	0.99	26.1	5.7	1.02	.265	3.05	64	3.20	74	7.15	143
2	Jake Peavy J. Peavy	1,010	150	68	44	.607	150	2.95	6	3	0	968.2	810	317	336	84	292	35	0	24	3,959	18	9.38	2.71	3.46	0.78	25.5	7.4	1.14	.286	3.12	74	3.17	75	7.53	117.4
3	Javier Vazquez J. Vazquez	939	163	63	61	.508	162	4.50	7	1	0	1041.1	1,035	521	550	145	273	44	0	13	4,397	33	8.12	2.36	3.44	1.25	21.4	6.2	1.26	.297	4.75	99	4.03	89	8.95	59.1
4	CC Sabathia	932	158	74	48	.607	158	3.40	22	9	0	1071.1	1,004	405	444	95	274	36	0	9	4,410	14	7.83	2.30	3.40	0.80	21.1	6.2	1.19	.296	3.73	78	3.40	79	8.43	111
5	Randy Johnson R. Johnson	918	142	65	46	.586	142	3.77	12	2	0	917.0	814	384	433	109	208	42	0	13	3,755	12	9.01	2.04	4.41	1.07	24.4	5.5	1.11	.285	4.25	84	3.44	78	7.99	101.2
6	Carlos Zambrano C. Zambrano	907	161	78	40	.661	161	3.45	5	2	0	1052.0	865	403	437	96	455	57	0	16	4,434	29	7.76	3.89	1.99	0.82	20.5	10.3	1.25	.263	3.74	77	4.03	90	7.40	51.7
7	Brandon Webb B. Webb	891	169	77	53	.592	169	3.30	14	7	0	1135.0	1,054	416	486	78	365	36	0	30	4,745	47	7.07	2.89	2.44	0.62	18.8	7.7	1.25	.289	3.85	72	3.49	77	8.36	127.1
8	Aaron Harang A. Harang	875	160	59	56	.513	158	4.13	11	5	0	1023.0	1,054	469	496	139	262	31	0	24	4,332	33	7.70	2.30	3.34	1.22	20.2	6.0	1.29	.302	4.36	93	4.03	89	9.27	57.8
9	Roy Oswalt R. Oswalt	875	169	86	47	.647	166	3.22	12	5	0	1120.0	1,116	401	430	90	255	42	1	20	4,653	13	7.03	2.05	3.43	0.72	18.8	5.5	1.22	.303	3.46	75	3.38	76	8.97	130.3
10	Josh Beckett J. Beckett	842	145	72	45	.615	145	3.91	5	2	0	915.0	843	398	423	101	260	37	0	7	3,798	29	8.28	2.56	3.24	0.99	22.2	6.8	1.21	.290	4.16	88	3.68	86	8.29	61
11	John Lackey J. Lackey	842	156	72	43	.626	155	3.66	10	5	0	1012.1	1,006	412	449	93	295	50	0	14	4,273	59	7.49	2.62	2.85	0.83	19.7	6.9	1.29	.305	3.99	83	3.66	84	8.94	79.2
12	A.J. Burnett	836	133	57	44	.564	131	3.78	10	3	0	851.2	766	358	397	77	308	40	1	8	3,588	41	8.83	3.25	2.71	0.81	23.3	8.6	1.26	.296	4.20	87	3.54	81	8.09	77
13	Oliver Perez O. Perez	792	135	47	45	.511	135	4.31	3	2	0	782.2	696	375	419	111	403	39	0	8	3,417	25	9.11	4.63	1.97	1.28	23.2	11.8	1.40	.282	4.82	101	4.63	107	8.00	-25.9
14	Doug Davis D. Davis	789	162	53	54	.495	162	4.12	3	2	0	972.0	965	445	481	93	433	25	0	20	4,242	27	7.31	4.01	1.82	0.86	18.6	10.2	1.44	.300	4.45	93	4.14	93	8.94	34.4
15	Ben Sheets B. Sheets	785	128	53	44	.546	128	3.24	15	3	0	839.1	767	302	334	87	152	10	0	7	3,404	30	8.42	1.63	5.16	0.93	23.1	4.5	1.09	.287	3.58	75	3.15	72	8.22	115.9
16	Scott Kazmir S. Kazmir	783	125	47	37	.560	124	3.61	1	1	0	723.0	656	290	323	72	332	25	0	9	3,108	31	9.75	4.13	2.36	0.90	25.2	10.7	1.37	.308	4.02	83	3.73	85	8.17	51.8
17	Ted Lilly T. Lilly	782	157	69	51	.575	157	4.27	2	1	0	917.0	853	435	456	137	347	23	0	13	3,916	26	7.68	3.41	2.25	1.34	20.0	8.9	1.31	.273	4.48	93	4.56	101	8.37	-5
18	Dan Haren D. Haren	769	149	62	45	.579	140	3.61	6	1	0	924.2	899	371	410	104	210	27	2	18	3,838	38	7.48	2.04	3.66	1.01	20.0	5.5	1.20	.291	3.99	83	3.69	84	8.75	72.7
19	Brett Myers B. Myers	759	178	51	46	.526	129	4.37	6	2	21	848.0	841	412	436	129	285	27	38	16	3,626	19	8.06	3.02	2.66	1.37	20.9	7.9	1.33	.293	4.63	99	4.38	98	8.93	10.5
20	Bronson Arroyo B. Arroyo	745	170	62	56	.525	164	4.14	5	1	0	1035.1	1,057	476	538	127	296	58	1	21	4,426	26	6.48	2.57	2.52	1.10	16.8	6.7	1.31	.291	4.68	91	4.29	96	9.19	22.6
21	Barry Zito B. Zito	736	169	62	64	.492	168	4.33	0	0	0	1039.0	980	500	541	121	454	43	0	21	4,492	20	6.38	3.93	1.62	1.05	16.4	10.1	1.38	.274	4.69	99	4.64	105	8.49	-28
22	Andy Pettitte A. Pettitte	727	153	66	49	.574	150	3.79	2	1	0	939.0	968	395	435	87	266	13	1	16	3,947	17	6.97	2.55	2.73	0.83	18.4	6.7	1.31	.309	4.17	86	3.66	83	9.28	77.1
23	Erik Bedard E. Bedard	710	127	46	38	.548	126	3.80	1	1	0	738.1	695	312	345	67	291	26	0	2	3,163	23	8.65	3.55	2.44	0.82	22.4	9.2	1.34	.304	4.21	85	3.66	81	8.47	71.2
24	Jeremy Bonderman J. Bonderman	704	136	53	47	.530	135	4.58	6	2	0	832.2	849	424	450	95	278	24	0	20	3,569	28	7.61	3.00	2.53	1.03	19.7	7.8	1.35	.306	4.86	103	3.99	90	9.18	42.1
25	John Smoltz J. Smoltz	698	179	47	27	.635	105	3.15	6	2	44	777.0	727	272	287	69	176	14	61	23	3,184	23	8.08	2.04	3.97	0.80	21.9	5.5	1.16	.295	3.32	73	3.20	73	8.42	101.1