Nolan Ryan has struck out the most career hitters, with 5,714 strikeouts.

	NAME	SO	G	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Nolan Ryan N. Ryan	5,714	807	324	292	.526	773	3.19	222	61	3	5386.0	3,923	1,911	2,178	321	2,795	158	13	78	22,575	277	9.55	4.67	2.04	0.54	25.3	12.4	1.25	.265	3.64	90	2.96	83	6.56	370.2
2	Randy Johnson R. Johnson	4,875	618	303	166	.646	603	3.29	100	37	2	4135.1	3,346	1,513	1,703	411	1,497	190	7	37	17,067	109	10.61	3.26	3.26	0.89	28.6	8.8	1.17	.291	3.71	75	3.18	73	7.28	554.3
3	Roger Clemens R. Clemens	4,672	709	354	184	.658	707	3.12	118	46	0	4916.2	4,185	1,707	1,885	363	1,580	159	0	63	20,240	143	8.55	2.89	2.96	0.66	23.1	7.8	1.17	.284	3.45	70	3.08	71	7.66	680.4
4	Steve Carlton S. Carlton	4,136	741	329	244	.574	709	3.22	254	55	2	5217.2	4,672	1,864	2,130	414	1,833	53	13	150	21,683	183	7.13	3.16	2.26	0.71	19.1	8.5	1.25	.279	3.67	87	3.14	86	8.06	271.5
5	Bert Blyleven B. Blyleven	3,701	692	287	250	.534	685	3.31	242	60	0	4970.0	4,632	1,830	2,029	430	1,322	155	3	71	20,491	114	6.70	2.39	2.80	0.78	18.1	6.5	1.20	.282	3.67	85	3.18	82	8.39	368.6
6	Tom Seaver T. Seaver	3,640	656	311	205	.603	647	2.86	231	61	1	4783.0	3,971	1,521	1,674	380	1,390	76	6	116	19,369	126	6.85	2.62	2.62	0.72	18.8	7.2	1.12	.259	3.15	79	3.03	85	7.47	286.1
7	Don Sutton D. Sutton	3,574	774	324	256	.559	756	3.26	178	58	5	5282.1	4,692	1,914	2,104	472	1,343	82	12	102	21,631	112	6.09	2.29	2.66	0.80	16.5	6.2	1.14	.261	3.58	92	3.23	90	7.99	181.2
8	Gaylord Perry G. Perry	3,534	777	314	265	.542	690	3.11	303	53	10	5350.0	4,938	1,846	2,128	399	1,379	108	33	164	21,953	160	5.95	2.32	2.56	0.67	16.1	6.3	1.18	.275	3.58	85	3.06	85	8.31	312.9
9	Walter Johnson W. Johnson	3,509	802	417	279	.599	666	2.17	531	110	34	5914.1	4,913	1,424	1,902	97	1,363	205	127		23,405	154	5.34	2.07	2.57	0.15	15.0	5.8	1.06	.264	2.89	68	2.42	76	7.48	472.8
10	Justin Verlander J. Verlander	3,416	526	262	147	.641	526	3.30	26	9	0	3415.2	2,891	1,252	1,354	355	952	115	0	27	13,945	97	9.00	2.51	3.59	0.94	24.5	6.8	1.13	.278	3.57	78	3.41	81	7.62	308.9
11	Max Scherzer M. Scherzer	3,407	466	215	112	.657	457	3.16	12	5	0	2878.0	2,346	1,010	1,083	335	756	112	2	20	11,629	78	10.65	2.36	4.51	1.05	29.3	6.5	1.08	.287	3.39	76	3.17	77	7.34	310.2
12	Greg Maddux G. Maddux	3,371	744	355	227	.610	740	3.16	109	35	0	5008.1	4,726	1,756	1,981	353	999	137	3	177	20,421	70	6.06	1.80	3.37	0.63	16.5	4.9	1.14	.281	3.56	76	3.25	78	8.49	519.5
13	Phil Niekro P. Niekro	3,342	864	318	274	.537	716	3.35	245	45	29	5404.0	5,044	2,012	2,337	482	1,809	123	83	86	22,677	226	5.57	3.01	1.85	0.80	14.7	8.0	1.27	.270	3.89	87	3.61	95	8.40	116.1
14	Fergie Jenkins F. Jenkins	3,192	664	284	226	.557	594	3.34	267	49	7	4500.2	4,142	1,669	1,853	484	997	84	37	116	18,400	62	6.38	1.99	3.20	0.97	17.3	5.4	1.14	.268	3.71	87	3.27	88	8.28	222.9
15	Pedro Martinez P. Martinez	3,154	476	219	100	.687	409	2.93	46	17	3	2827.1	2,221	919	1,006	239	760	141	23	30	11,394	62	10.04	2.42	4.15	0.76	27.7	6.7	1.05	.279	3.20	66	2.91	68	7.07	454.6
16	Bob Gibson B. Gibson	3,117	528	251	174	.591	482	2.91	255	56	6	3884.1	3,279	1,258	1,420	257	1,336	102	21	118	16,068	108	7.22	3.10	2.33	0.60	19.4	8.3	1.19	.268	3.29	78	2.89	81	7.60	290.5
17	Curt Schilling C. Schilling	3,116	569	216	146	.597	436	3.46	83	20	22	3261.0	2,998	1,253	1,318	347	711	52	81	43	13,284	72	8.60	1.96	4.38	0.96	23.5	5.4	1.14	.293	3.64	80	3.22	76	8.27	373.6
18	CC Sabathia	3,093	561	251	161	.609	560	3.74	38	12	0	3577.1	3,404	1,485	1,623	382	1,099	123	0	44	14,989	74	7.78	2.76	2.81	0.96	20.6	7.3	1.26	.294	4.08	87	3.77	87	8.56	223.7
19	John Smoltz J. Smoltz	3,084	723	213	155	.579	481	3.33	53	16	154	3473.0	3,074	1,284	1,391	288	1,010	57	204	84	14,271	145	7.99	2.62	3.05	0.75	21.6	7.1	1.18	.283	3.60	81	3.23	78	7.97	356.6
20	Zack Greinke Z. Greinke	2,979	586	225	156	.591	541	3.49	17	5	1	3389.1	3,207	1,315	1,410	367	762	79	8	25	13,877	101	7.91	2.02	3.91	0.97	21.5	5.5	1.17	.293	3.74	83	3.51	85	8.52	235
21	Clayton Kershaw C. Kershaw	2,968	432	212	94	.693	429	2.50	25	15	0	2742.2	2,091	762	835	227	678	44	1	28	10,816	103	9.74	2.22	4.38	0.74	27.4	6.3	1.01	.270	2.74	64	2.82	70	6.86	366.8
22	Jim Bunning J. Bunning	2,855	591	224	184	.549	519	3.27	151	40	16	3760.1	3,433	1,366	1,527	372	1,000	160	39	98	15,618	47	6.83	2.39	2.86	0.89	18.3	6.4	1.18	.273	3.65	88	3.22	88	8.22	195.2
23	Mickey Lolich M. Lolich	2,832	586	217	191	.532	496	3.44	195	41	10	3638.1	3,366	1,390	1,537	347	1,099	92	40	67	15,140	124	7.01	2.72	2.58	0.86	18.7	7.3	1.23	.280	3.80	96	3.19	87	8.33	188.5
24	Mike Mussina M. Mussina	2,813	537	270	153	.638	536	3.68	57	23	0	3562.2	3,460	1,458	1,559	376	785	60	0	29	14,593	71	7.11	1.98	3.58	0.95	19.3	5.4	1.19	.292	3.94	82	3.57	79	8.74	372.8
25	Cy Young C. Young	2,803	906	511	316	.618	815	2.63	749	76	17	7356.0	7,092	2,147	3,167	138	1,217	161	84		29,565	156	3.43	1.49	2.30	0.17	9.5	4.1	1.13	.275	3.87	74	2.84	79	8.68	620