Rickey Henderson has the most career runs, with 2,295 runs.

Interpreted as:

game with most run by a player MLB all-time

	NAME	R	G	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Rickey Henderson R. Henderson	2,295	1,652	6,104	2,227	393	60	297	892	1,482	68	809	1,063	164	7,692	3,631	750	12	26	30	77	.365	.492	.595	1.087
2	Ty Cobb T. Cobb	2,246	1,614	6,337	2,871	522	247	117		805	61		687		7,369	4,238	886	168				.453		.669
3	Barry Bonds B. Bonds	2,227	1,603	5,458	2,211	443	68	762	1,703	1,607	70	734	344	59	7,181	5,076	1,273	1	45	418	87	.405	.542	.930	1.472
4	Hank Aaron H. Aaron	2,175	1,633	6,440	2,566	406	75	755	1,870	824	22	591	162	33	7,350	5,387	1,236	9	55	174	138	.398	.465	.836	1.301
5	Babe Ruth B. Ruth	2,173	1,480	5,244	2,249	413	116	714	1,917	1,431	29	687	94		6,765	5,036	1,243	61				.429	.553	.960	1.514
6	Pete Rose P. Rose	2,165	1,648	6,755	2,687	532	99	160	844	933	72	474	145	72	7,818	3,897	791	21	37	98	102	.398	.474	.577	1.050
7	Willie Mays W. Mays	2,060	1,501	5,760	2,352	356	118	660	1,555	886	24	656	239	50	6,714	4,924	1,134	5	39	127	110	.408	.486	.855	1.341
8	Alex Rodriguez A. Rodriguez	2,021	1,434	5,600	2,278	386	26	696	1,716	843	113	995	220	38	6,618	4,804	1,108	9	53	63	124	.407	.489	.858	1.347
9	Stan Musial S. Musial	1,949	1,438	5,574	2,429	496	130	475	1,459	920	32	281	56	9	6,559	4,610	1,101	11	22	62	107	.436	.516	.827	1.343
10	Derek Jeter D. Jeter	1,923	1,418	5,892	2,310	400	55	260	961	697	100	849	256	45	6,771	3,600	715	50	32	22	136	.392	.462	.611	1.073
11	Albert Pujols A. Pujols	1,914	1,432	5,585	2,280	456	15	703	1,732	748	65	567	75	18	6,450	4,875	1,174	0	52	192	150	.408	.480	.873	1.352
12	Lou Gehrig L. Gehrig	1,888	1,289	4,940	2,072	419	137	493	1,659	1,015	30	405	81		6,047	4,244	1,049	62			0	.419	.521	.859	1.380
13	Tristram Speaker T. Speaker	1,881	1,388	5,341	2,359	564	177	117		827	60		313		6,384	3,628	858	156				.442	.521	.679	1.200
14	Mel Ott M. Ott	1,859	1,351	4,945	1,992	342	54	511	1,477	1,054	40	387	62		6,085	3,975	907	46			13	.403	.511	.804	1.315
15	Craig Biggio C. Biggio	1,844	1,354	5,442	2,038	461	47	291	853	707	176	770	278	52	6,406	3,466	799	40	41	40	63	.374	.459	.637	1.096
16	Frank Robinson F. Robinson	1,830	1,365	5,047	2,055	373	58	586	1,468	816	114	641	148	34	6,032	4,302	1,017	10	45	129	126	.407	.496	.852	1.348
17	Eddie Collins E. Collins	1,822	1,365	4,984	2,096	303	140	47		957	56		505		6,243	2,820	490	246				.421	.518	.566	1.084
18	Carl Yastrzemski C. Yastrzemski	1,816	1,408	5,246	2,135	401	48	452	1,314	958	23	525	107	40	6,273	3,988	901	8	38	104	120	.407	.497	.760	1.258
19	Ted Williams T. Williams	1,799	1,247	4,414	1,906	364	53	521	1,498	1,298	30	345	15	2	5,751	3,939	938	3	6	50	98	.432	.563	.892	1.455
20	Paul Molitor P. Molitor	1,782	1,333	5,548	2,234	440	91	234	940	668	30	502	361	58	6,339	3,558	765	43	50	60	97	.403	.466	.641	1.107
21	Charlie Gehringer C. Gehringer	1,775	1,242	5,021	2,021	448	125	184	1,063	778	32	158	138		5,902	3,271	757	71			13	.403	.486	.651	1.137
22	Jimmie Foxx J. Foxx	1,751	1,239	4,598	1,946	336	99	534	1,590	972	8	628	68		5,617	4,082	969	39			37	.423	.525	.888	1.412
23	Mickey Mantle M. Mantle	1,675	1,238	4,414	1,743	228	52	536	1,278	1,078	5	799	115	19	5,527	3,683	816	8	22	82	47	.395	.512	.834	1.346
24	Dave Winfield D. Winfield	1,669	1,303	5,080	2,034	363	67	465	1,344	691	14	655	130	42	5,827	3,926	895	7	35	104	119	.400	.471	.773	1.243
25	Johnny Damon J. Damon	1,668	1,254	5,181	1,939	383	93	235	864	664	19	561	292	36	5,928	3,213	711	30	34	22	39	.374	.445	.620	1.065