Chi Chi González had the highest ERA with 99.0+ innings pitched in 2021, with an ERA of 6.46.

Interpreted as:

highest era by a player in 2021, min 99 ip

	NAME	ERA	IP	SEASON	TM	G	W	L	W%	GS	SO	CG	SHO	SV	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Chi Chi González C. Chi González	6.46	101.2	2021	COL	24	3	7	.300	18	56	0	0	0	127	73	74	18	28	6	1	0	448	2	4.96	2.48	2.00	1.59	12.5	6.3	1.52	.321	6.55	134	5.37	121	11.24	-9.6
2	Matt Harvey M. Harvey	6.27	127.2	2021	BAL	28	6	14	.300	28	95	0	0	0	160	89	96	19	37	5	0	1	582	3	6.70	2.61	2.57	1.34	16.3	6.4	1.54	.331	6.77	142	4.60	101	11.28	-0.5
3	Mitch Keller M. Keller	6.17	100.2	2021	PIT	23	5	11	.313	23	92	0	0	0	131	69	69	10	49	7	0	1	470	2	8.23	4.38	1.88	0.89	19.6	10.4	1.79	.388	6.17	146	4.29	101	11.71	-0.6
4	Jorge López J. López	6.07	121.2	2021	BAL	33	3	14	.176	25	112	0	0	0	142	82	83	21	56	10	2	2	555	9	8.28	4.14	2.00	1.55	20.2	10.1	1.63	.340	6.14	138	5.19	115	10.50	-8.1
5	Andrew Heaney A. Heaney	5.83	129.2	2021	TOT	30	8	9	.471	23	150	0	0	0	130	84	85	29	41	6	2	0	558	4	10.41	2.85	3.66	2.01	26.9	7.3	1.32	.304	5.90	134	4.84	111	9.02	-7
6	Patrick Corbin P. Corbin	5.82	171.2	2021	WSH	31	9	16	.360	31	143	0	0	0	192	111	114	37	60	3	0	2	751	0	7.50	3.15	2.38	1.94	19.0	8.0	1.47	.305	5.98	139	5.40	126	10.07	-21
7	José Ureña J. Ureña	5.81	100.2	2021	DET	26	4	8	.333	18	67	0	0	0	119	65	70	14	42	4	1	0	456	4	5.99	3.75	1.60	1.25	14.7	9.2	1.60	.319	6.26	135	5.01	118	10.64	-8.8
8	J.A. Happ	5.79	152.1	2021	TOT	30	10	8	.556	30	122	0	0	0	177	98	100	30	48	3	0	0	671	4	7.21	2.84	2.54	1.77	18.2	7.2	1.48	.314	5.91	137	5.13	122	10.46	-15.8
9	Zach Davies Z. Davies	5.78	148.0	2021	CHC	32	6	12	.333	32	114	0	0	0	162	95	99	25	75	5	0	2	668	0	6.93	4.56	1.52	1.52	17.1	11.2	1.60	.305	6.02	139	5.44	130	9.85	-20.7
10	Wil Crowe W. Crowe	5.48	116.2	2021	PIT	26	4	8	.333	25	111	0	0	0	126	71	75	25	57	6	0	1	524	3	8.56	4.40	1.95	1.93	21.2	10.9	1.57	.311	5.79	129	5.67	134	9.72	-18.5
11	Erick Fedde E. Fedde	5.47	133.1	2021	WSH	29	7	9	.438	27	128	0	0	0	144	81	90	23	48	4	1	6	590	1	8.64	3.24	2.67	1.55	21.7	8.1	1.44	.313	6.07	130	4.65	109	9.72	-5.4
12	Mike Foltynewicz M. Foltynewicz	5.44	139.0	2021	TEX	28	2	12	.143	24	97	0	0	0	139	84	86	35	36	9	0	0	586	2	6.28	2.33	2.69	2.27	16.6	6.1	1.26	.254	5.57	123	6.01	136	9.00	-23.9
13	Kolby Allard K. Allard	5.41	124.2	2021	TEX	32	3	12	.200	17	104	0	0	0	128	75	80	29	31	4	3	0	534	4	7.51	2.24	3.35	2.09	19.5	5.8	1.28	.270	5.78	123	5.36	122	9.24	-12.7
14	Brad Keller B. Keller	5.39	133.2	2021	KCR	26	8	12	.400	26	120	0	0	0	158	80	89	18	64	7	0	1	613	5	8.08	4.31	1.88	1.21	19.6	10.4	1.66	.347	5.99	120	4.71	111	10.64	-7.2
15	JT Brubaker	5.36	124.1	2021	PIT	24	5	13	.278	24	129	0	0	0	123	74	75	28	38	9	0	1	538	3	9.34	2.75	3.39	2.03	24.0	7.1	1.29	.284	5.43	126	5.15	121	8.90	-12.6
16	Dallas Keuchel D. Keuchel	5.28	162.0	2021	CWS	32	9	9	.500	30	95	0	0	0	189	95	105	25	59	7	0	1	720	5	5.28	3.28	1.61	1.39	13.2	8.2	1.53	.307	5.83	121	5.22	117	10.50	-13.1
17	Jordan Lyles J. Lyles	5.15	180.0	2021	TEX	32	10	13	.435	30	146	0	0	0	194	103	104	38	56	7	1	0	769	9	7.30	2.80	2.61	1.90	19.0	7.3	1.39	.299	5.20	117	5.33	121	9.70	-17.8
18	Ryan Yarbrough R. Yarbrough	5.11	155.0	2021	TBR	30	9	7	.563	21	117	1	0	0	163	88	96	25	27	9	0	2	653	1	6.79	1.57	4.33	1.45	17.9	4.1	1.23	.291	5.57	125	4.45	108	9.46	-6.4
19	Josh Fleming J. Fleming	5.09	104.1	2021	TBR	26	10	8	.556	11	65	0	0	1	110	59	60	11	31	3	1	5	448	0	5.61	2.67	2.10	0.95	14.5	6.9	1.35	.293	5.18	124	4.26	104	9.49	-2.1
20	Chris Paddack C. Paddack	5.07	108.1	2021	SDP	23	7	7	.500	22	99	0	0	0	115	61	67	15	22	1	0	1	459	2	8.22	1.83	4.50	1.25	21.6	4.8	1.26	.311	5.57	128	3.77	90	9.55	5.1
21	Alec Mills A. Mills	5.07	119.0	2021	CHC	32	6	7	.462	20	87	0	0	1	137	67	75	16	34	7	4	2	517	4	6.58	2.57	2.56	1.21	16.8	6.6	1.44	.324	5.67	122	4.48	107	10.36	-3.8
22	Michael Wacha M. Wacha	5.05	124.2	2021	TBR	29	3	5	.375	23	121	0	0	0	132	70	73	23	31	4	1	0	528	5	8.74	2.24	3.90	1.66	22.9	5.9	1.31	.312	5.27	123	4.46	109	9.53	-5.4
23	Mike Minor M. Minor	5.05	158.2	2021	KCR	28	8	12	.400	28	149	0	0	0	156	89	92	26	41	5	0	0	669	4	8.45	2.33	3.63	1.47	22.3	6.1	1.24	.290	5.22	112	4.28	101	8.85	-1
24	Triston McKenzie T. McKenzie	4.95	120.0	2021	CLE	25	5	9	.357	24	136	0	0	0	84	66	66	21	58	3	0	0	495	2	10.20	4.35	2.34	1.58	27.5	11.7	1.18	.227	4.95	117	4.70	112	6.30	-7
25	Brady Singer B. Singer	4.91	128.1	2021	KCR	27	5	10	.333	27	131	1	0	0	146	70	81	14	53	11	0	1	586	3	9.19	3.72	2.47	0.98	22.4	9.0	1.55	.350	5.68	109	4.03	95	10.24	2.8