Bobo Newsom has the highest ERA with 200+ strikeouts in a season, with an ERA of 5.08 in 1938.

Interpreted as:

highest era by a player in a season with 200+ k

	NAME	ERA	SO	SEASON	TM	G	W	L	W%	GS	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Bobo Newsom B. Newsom	5.08	226	1938	SLA	44	20	16	.556	40	31	0	1	329.2	334	186	205	30	192	5	3		1,475	3	6.17	5.24	1.18	0.82	15.3	13.0	1.60	.297	5.60	101	4.53	94	9.12	11.6
2	Pedro Astacio P. Astacio	5.04	210	1999	COL	34	17	11	.607	34	7	0	0	232.0	258	130	140	38	75	11	0	6	1,008	5	8.15	2.91	2.80	1.47	20.8	7.4	1.44	.326	5.43	91	4.55	90	10.01	13.3
3	Robbie Ray R. Ray	4.90	218	2016	ARI	32	8	15	.348	32	0	0	0	174.1	185	95	105	24	71	6	0	4	776	8	11.25	3.67	3.07	1.24	28.1	9.1	1.47	.352	5.42	112	3.75	90	9.55	8
4	Lucas Giolito L. Giolito	4.88	204	2023	TOT	33	7	15	.318	33	0	0	0	184.1	169	100	110	41	73	9	0	2	794	5	9.96	3.56	2.79	2.00	25.7	9.2	1.31	.274	5.37	113	5.26	120	8.25	-17.8
5	Mark Langston M. Langston	4.85	245	1986	SEA	37	12	14	.462	36	9	0	0	239.1	234	129	142	30	123	4	1	1	1,057	10	9.21	4.63	1.99	1.13	23.2	11.6	1.49	.311	5.34	113	3.93	90	8.80	11.4
6	Michael Pineda M. Pineda	4.82	207	2016	NYY	32	6	12	.333	32	0	0	0	175.2	184	94	98	27	53	6	0	1	756	7	10.61	2.72	3.91	1.38	27.4	7.0	1.35	.339	5.02	113	3.79	86	9.43	11.9
7	Mike Mussina M. Mussina	4.81	204	1996	BAL	36	19	11	.633	36	4	1	0	243.1	264	130	137	31	69	3	0	0	1,039	3	7.55	2.55	2.96	1.15	19.6	6.6	1.37	.318	5.07	97	4.03	82	9.76	23.9
8	Brandon Morrow B. Morrow	4.72	203	2011	TOR	30	11	11	.500	30	0	0	0	179.1	162	94	103	21	69	12	0	1	777	12	10.19	3.46	2.94	1.05	26.1	8.9	1.29	.299	5.17	113	3.63	88	8.13	9.7
9	Javier Vazquez J. Vazquez	4.67	200	2008	CWS	33	12	16	.429	33	1	0	0	208.1	214	108	113	25	61	6	0	2	890	2	8.64	2.64	3.28	1.08	22.5	6.9	1.32	.316	4.88	103	3.73	82	9.24	18.1
10	Aaron Nola A. Nola	4.63	223	2021	PHI	32	9	9	.500	32	1	1	0	180.2	165	93	95	26	39	9	0	1	749	0	11.11	1.94	5.72	1.30	29.8	5.2	1.13	.308	4.73	110	3.36	78	8.22	19.1
11	Dylan Cease D. Cease	4.58	214	2023	CWS	33	7	9	.438	33	0	0	0	177.0	172	90	98	19	79	9	0	3	784	13	10.88	4.02	2.71	0.97	27.3	10.1	1.42	.330	4.98	106	3.72	84	8.75	13.4
12	Matthew Boyd M. Boyd	4.56	238	2019	DET	32	9	12	.429	32	0	0	0	185.1	178	94	101	39	50	8	0	1	788	6	11.56	2.43	4.76	1.89	30.2	6.3	1.23	.307	4.90	99	4.31	94	8.64	5.3
13	Dylan Cease D. Cease	4.55	215	2025	SDP	32	8	12	.400	32	0	0	0	168.0	152	85	91	21	71	5	0	2	722	5	11.52	3.80	3.03	1.13	29.8	9.8	1.33	.320	4.88	113	3.55	87	8.14	10.1
14	Todd Stottlemyre T. Stottlemyre	4.55	205	1995	OAK	31	14	7	.667	31	2	0	0	209.2	228	106	117	26	80	6	0	7	920	11	8.80	3.43	2.56	1.12	22.3	8.7	1.47	.335	5.02	100	3.98	86	9.79	15.1
15	Hideo Nomo H. Nomo	4.50	220	2001	BOS	33	13	10	.565	33	2	2	0	198.0	171	99	105	26	96	3	0	2	849	6	10.00	4.36	2.29	1.18	25.9	11.3	1.35	.288	4.77	99	4.03	94	7.77	5.7
16	Trevor Bauer T. Bauer	4.48	253	2019	TOT	34	11	13	.458	34	1	1	0	213.0	184	106	118	34	82	19	0	0	911	10	10.69	3.46	3.09	1.44	27.8	9.0	1.25	.287	4.99	97	4.32	95	7.77	5.3
17	Aaron Nola A. Nola	4.46	202	2023	PHI	32	12	9	.571	32	0	0	0	193.2	178	96	105	32	45	1	0	0	793	2	9.39	2.09	4.49	1.49	25.5	5.7	1.15	.285	4.88	102	4.03	90	8.27	9.4
18	Chuck Finley C. Finley	4.43	200	1999	ANA	33	12	11	.522	33	1	0	0	213.1	197	105	117	23	94	8	0	2	913	15	8.44	3.97	2.13	0.97	21.9	10.3	1.36	.296	4.94	89	4.08	84	8.31	18.9
19	Jeff Samardzija J. Samardzija	4.42	205	2017	SFG	32	9	15	.375	32	1	1	0	207.2	204	102	107	30	32	6	0	1	847	2	8.88	1.39	6.41	1.30	24.2	3.8	1.14	.303	4.64	106	3.60	89	8.84	10.6
20	Chris Sale C. Sale	4.40	218	2019	BOS	25	6	11	.353	25	1	1	0	147.1	123	72	80	24	37	13	0	0	612	2	13.32	2.26	5.89	1.47	35.6	6.0	1.09	.309	4.89	91	3.38	75	7.51	18.8
21	Daisuke Matsuzaka D. Matsuzaka	4.40	201	2007	BOS	32	15	12	.556	32	1	0	0	204.2	191	100	100	25	80	13	0	1	874	5	8.84	3.52	2.51	1.10	23.0	9.2	1.32	.299	4.40	95	4.22	98	8.40	1.7
22	Charlie Morton C. Morton	4.34	205	2022	ATL	31	9	6	.600	31	0	0	0	172.0	149	83	85	28	63	18	0	0	728	4	10.73	3.30	3.25	1.47	28.2	8.7	1.23	.292	4.45	106	4.25	108	7.80	-6
23	Jeff Samardzija J. Samardzija	4.34	214	2013	CHC	33	8	13	.381	33	2	1	0	213.2	210	103	109	25	78	8	0	3	914	11	9.01	3.29	2.74	1.05	23.4	8.5	1.35	.314	4.59	116	3.77	99	8.85	0.8
24	Robbie Ray R. Ray	4.34	235	2019	ARI	33	12	8	.600	33	0	0	0	174.1	150	84	91	30	84	5	0	5	747	7	12.13	4.34	2.80	1.55	31.5	11.2	1.34	.305	4.70	98	4.28	99	7.74	1
25	Jersey Bakley J. Bakley	4.29	226	1884	TOT	46	16	30	.348	45	43	1	0	394.2	443	188	338	0	81		1		1,752	56	5.15	1.85	2.79	0.00	12.9	4.6	1.33		7.71	144	2.74	106	10.10	-9.3