The Philadelphia Phillies have the lowest run differential by a team, with a differential of -5,608 runs.

	TEAM	DIFF	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Phillies	-5,608	21,806	.475	10,300	11,391	746,125	96,885	194,290	33,608	6,695	14,352	87,095	68,089	5,457	106,259	15,040	2,935	834,641	284,344	54,655	11,927	3,043	3,752	9,925	.260	.326	.381	.707
2	Orioles	-5,460	19,472	.475	9,194	10,168	661,381	84,080	170,585	29,511	4,923	14,562	77,752	63,624	4,527	99,346	10,642	2,807	743,196	253,628	48,996	10,534	3,130	2,587	10,908	.258	.326	.383	.709
3	Twins	-3,347	19,481	.481	9,327	10,045	664,508	85,645	174,179	29,922	6,346	12,156	78,860	62,713	5,220	95,409	12,100	3,102	745,827	253,261	48,424	10,197	3,189	2,670	11,045	.262	.329	.381	.710
4	Athletics	-3,087	19,433	.486	9,404	9,942	658,731	85,801	169,542	29,408	5,342	14,297	79,088	64,854	4,767	100,020	12,163	3,228	742,177	252,525	49,047	10,697	3,128	2,281	10,688	.257	.327	.383	.710
5	Padres	-2,805	9,005	.468	4,214	4,789	304,394	36,524	75,910	13,444	1,772	7,365	34,352	28,968	2,170	60,282	6,073	2,624	341,558	114,993	22,581	3,748	2,278	2,699	6,573	.249	.317	.378	.695
6	Marlins	-2,250	5,170	.460	2,380	2,790	175,777	21,791	44,774	8,525	1,003	4,717	20,663	15,878	1,870	39,114	3,345	1,320	196,561	69,456	14,245	1,727	1,309	1,211	3,868	.255	.321	.395	.716
7	Rockies	-2,160	5,178	.457	2,364	2,814	177,746	25,500	47,931	9,460	1,331	5,842	24,255	16,237	1,612	38,736	3,119	1,396	198,996	77,579	16,633	2,019	1,382	1,209	3,947	.270	.334	.436	.770
8	Royals	-2,156	8,991	.477	4,287	4,702	307,454	39,299	80,685	15,114	2,302	7,126	37,106	26,297	2,511	52,853	7,157	2,921	341,343	121,781	24,542	2,388	2,693	1,878	6,853	.262	.323	.396	.719
9	Rangers	-2,001	10,284	.477	4,898	5,380	351,062	46,277	90,474	16,143	1,902	10,319	43,732	33,249	2,743	66,082	6,036	2,867	392,884	141,378	28,364	2,971	2,859	2,267	7,860	.258	.324	.403	.727
10	Colonels	-1,890	2,355	.429	993	1,320	82,256	12,464	21,505	2,816	1,292	436	8,508	6,080	757	3,638	3,474		89,787	28,213	4,544	609				.261	.319	.343	.662
11	Senators	-1,865	1,265	.366	454	788	43,645	6,912	11,886	1,615	787	357	5,764	4,269	575	3,492	1,975		48,963	16,146	2,759	474				.272	.345	.370	.715
12	Nationals	-1,633	8,997	.481	4,330	4,663	304,265	37,692	77,163	14,893	1,810	7,707	35,435	28,552	2,661	58,115	6,630	2,809	341,681	118,797	24,410	3,888	2,315	2,891	6,574	.254	.321	.390	.711
13	Mariners	-1,583	7,709	.479	3,688	4,019	262,956	34,272	67,531	12,586	1,265	7,901	32,562	24,917	2,412	50,712	5,130	2,192	294,350	106,350	21,752	1,962	2,103	1,687	5,754	.257	.324	.404	.729
14	Nationals	-1,080	514	.326	163	337	17,337	2,160	3,944	533	220	125	1,647	1,246	127		1,040		18,710	5,292	878					.227	.284	.305	.589
15	Angels	-809	10,297	.495	5,092	5,202	349,287	44,546	89,259	15,431	1,822	9,369	41,926	32,675	2,891	63,872	6,112	3,119	391,195	136,441	26,622	3,547	2,795	2,500	7,945	.256	.322	.391	.713
16	Orioles	-802	944	.437	403	519	32,654	4,964	7,699	1,083	504	136	2,635	2,289	208		1,451		35,293	10,198	1,723					.236	.293	.312	.605
17	Mets	-778	10,130	.484	4,897	5,225	342,733	41,877	85,643	15,306	1,825	8,746	39,452	32,781	2,919	65,878	5,993	2,747	385,088	130,837	25,877	4,000	2,655	3,159	7,535	.250	.318	.382	.700
18	Spiders	-672	1,802	.469	827	938	63,232	10,057	17,006	2,308	961	292	8,238	5,871	580	3,144	2,800		70,233	22,112	3,561	550				.269	.337	.350	.686
19	Brewers	-639	9,001	.489	4,404	4,593	305,590	40,102	78,299	14,596	1,769	8,829	37,988	29,430	2,759	59,765	6,083	2,770	343,410	122,920	25,194	3,177	2,454	2,167	6,680	.256	.325	.402	.727
20	Reds	-638	348	.365	125	217	12,768	1,643	3,191	408	157	30		318					13,086	4,003	595					.250		.314
21	Hoosiers	-540	398	.370	146	249	13,870	2,050	3,536	570	138	129	1,577	913	131		936		14,914	4,769	837					.255	.307	.344	.651
22	Cowboys	-496	271	.364	98	171	9,535	1,431	2,256	304	137	37	1,052	718	123		729		10,376	2,945	478					.237	.298	.309	.607
23	Rays	-427	4,428	.490	2,168	2,260	150,532	19,688	38,197	7,593	863	4,631	18,729	14,272	1,709	34,367	3,338	1,261	168,449	61,409	13,087	753	1,183	695	3,097	.254	.323	.408	.731
24	Bisons	-406	134	.273	36	96	4,795	793	1,249	180	64	20	630	541	96	367	160		5,432	1,617	264					.260	.347	.337	.684
25	Trojans	-388	330	.412	134	191	11,951	1,542	2,929	456	151	26		414					12,365	3,765	633					.245		.315