David Ortiz has the most career at-bats by a designated hitter, with 8,313 at-bats.

	NAME	AB	G	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS	WRC	WRAA	WOBA	WRC+	BRAA
1	David Ortiz D. Ortiz	8,313	2,307	1,362	2,379	609	19	531	1,716	1,278	33	1,659	16	9	9,714	4,619	1,159	2	88	206	227	.286	.380	.556	.936	1705	551.7	.393	141	479.3
2	Harold Baines H. Baines	6,154	1,838	807	1,789	306	11	244	1,039	799	7	902	5	16	7,015	2,849	561	1	54	127	201	.291	.370	.463	.833	1048	212.1	.363	122	188.7
3	Hal McRae H. McRae	5,750	1,605	779	1,698	393	54	155	891	535	64	612	92	63	6,432	2,664	602	17	66	56	140	.295	.358	.463	.821	940	223.6	.364	126	193.1
4	Edgar Martinez E. Martinez	5,082	1,445	877	1,593	369	6	251	1,006	995	65	927	26	16	6,201	2,727	626	1	58	95	138	.313	.428	.537	.965	1206	428.4	.414	152	418.4
5	Paul Molitor P. Molitor	5,054	1,261	843	1,613	309	53	119	756	558	24	557	187	40	5,713	2,385	481	16	61	61	112	.319	.385	.472	.857	909	219.6	.375	126	183.4
6	Frank Thomas F. Thomas	4,937	1,404	813	1,385	280	6	296	959	926	62	927	15	10	5,985	2,565	582	0	60	63	123	.281	.396	.520	.916	1057	318	.394	139	296
7	Don Baylor D. Baylor	4,878	1,372	746	1,235	220	8	225	789	488	179	692	87	49	5,620	2,146	453	6	69	60	124	.253	.339	.440	.779	749	114.4	.345	116	101.6
8	Chili Davis C. Davis	4,365	1,249	646	1,227	227	6	206	771	716	9	893	35	26	5,136	2,084	439	1	45	98	127	.281	.380	.477	.858	808	187.4	.373	124	158
9	Travis Hafner T. Hafner	4,058	1,183	619	1,107	250	13	213	731	598	90	976	11	7	4,775	2,022	476	0	29	81	86	.273	.376	.498	.874	766	193.9	.374	132	189.5
10	Nelson Cruz N. Cruz	4,020	1,099	596	1,101	179	6	263	743	429	64	1,041	16	7	4,551	2,081	448	0	38	50	116	.274	.350	.518	.868	727	188.9	.366	135	191.8
11	Billy Butler B. Butler	3,902	1,097	437	1,107	226	4	111	557	373	27	659	4	3	4,336	1,674	341	0	34	48	155	.284	.348	.429	.777	564	70.5	.337	110	52
12	Shohei Ohtani S. Ohtani	3,730	1,018	708	1,050	192	45	280	669	541	25	1,104	165	43	4,316	2,172	517	0	20	88	49	.282	.374	.582	.957	807	292.3	.397	156	288.6
13	Victor Martinez V. Martinez	3,558	969	405	1,033	188	0	115	540	319	25	409	4	4	3,942	1,566	303	0	40	67	131	.290	.349	.440	.789	521	73.7	.339	113	56.4
14	Kendrys Morales K. Morales	3,550	980	413	933	185	3	154	536	306	35	748	2	4	3,916	1,586	342	0	25	23	125	.263	.325	.447	.772	502	53.8	.332	110	46.8
15	Edwin Encarnacion E. Encarnacion	3,365	929	545	878	166	2	220	636	474	45	726	31	7	3,925	1,708	388	0	41	29	94	.261	.356	.508	.864	619	161.2	.367	131	141.8
16	J.D. Martinez	3,324	870	506	936	222	11	179	595	353	26	928	10	1	3,738	1,717	412	0	35	31	110	.282	.352	.517	.868	605	156.4	.365	130	137.6
17	Jose Canseco J. Canseco	3,171	855	542	844	155	5	217	627	457	39	882	66	29	3,700	1,660	377	0	33	27	83	.266	.362	.523	.886	607	139.3	.379	123	114.8
18	Willie Horton W. Horton	2,913	787	304	778	103	10	102	425	244	11	540	7	11	3,201	1,207	215	6	27	35	88	.267	.323	.414	.738	379	20.9	.329	101	2
19	Andre Thornton A. Thornton	2,857	806	387	728	120	2	127	481	432	7	436	27	18	3,344	1,233	249	5	43	45	81	.255	.350	.432	.781	449	72.3	.346	113	49.1
20	Cliff Johnson C. Johnson	2,722	922	366	718	134	5	138	488	370	36	479	8	10	3,158	1,276	277	3	27	31	53	.264	.356	.469	.825	469	112.3	.365	126	98
21	Brian Downing B. Downing	2,652	758	425	717	125	11	109	339	413	59	408	10	12	3,152	1,191	245	8	20	25	53	.270	.378	.449	.827	485	129.3	.370	132	120.5
22	Giancarlo Stanton G. Stanton	2,638	722	359	642	108	1	183	484	306	18	895	6	1	2,982	1,301	292	0	20	17	84	.243	.324	.493	.817	435	81.4	.347	124	84.4
23	Jim Thome J. Thome	2,503	805	432	663	127	2	182	506	490	19	786	1	1	3,032	1,340	311	0	20	46	59	.265	.387	.535	.922	530	165.9	.393	139	145.9
24	Rico Carty R. Carty	2,476	707	298	718	128	3	90	397	276	3	238	8	7	2,786	1,122	221	1	30	29	91	.290	.358	.453	.811	398	89.4	.363	126	79.4
25	Yordan Alvarez Y. Alvarez	2,455	677	429	728	156	6	170	493	346	40	566	9	2	2,867	1,406	332	0	26	42	60	.297	.389	.573	.961	549	206.4	.402	163	212.4