Roger Clemens has struck out the most career batters when the count has been full, with 705 strikeouts.
| NAME | SO | G | H | HR | BB | HBP | IBB | K/BB | ||
|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | R. Clemens | 705 | 601 | 327 | 32 | 718 | 2 | 0 | 0.98 |
| 2 |  | R. Johnson | 650 | 578 | 247 | 28 | 673 | 9 | 0 | 0.97 |
| 3 |  | J. Verlander | 538 | 528 | 251 | 36 | 563 | 5 | 0 | 0.96 |
| 4 |  | Z. Greinke | 502 | 551 | 296 | 46 | 439 | 1 | 0 | 1.14 |
| 5 |  | M. Scherzer | 482 | 456 | 213 | 41 | 442 | 6 | 0 | 1.09 |
| 6 |  | CC Sabathia | 481 | 547 | 246 | 32 | 538 | 2 | 0 | 0.89 |
| 7 |  | P. Martinez | 479 | 436 | 178 | 24 | 377 | 4 | 0 | 1.27 |
| 8 |  | C. Hamels | 459 | 406 | 168 | 18 | 394 | 2 | 0 | 1.16 |
| 9 |  | J. Lester | 444 | 443 | 273 | 43 | 467 | 3 | 0 | 0.95 |
| 10 |  | G. Maddux | 434 | 615 | 212 | 20 | 348 | 5 | 0 | 1.25 |
| 11 | | T. Glavine | 431 | 630 | 357 | 34 | 566 | 1 | 0 | 0.76 |
| 12 | | A. Leiter | 430 | 386 | 255 | 34 | 507 | 3 | 1 | 0.85 |
| 13 | | L. Hernandez | 423 | 486 | 294 | 38 | 497 | 4 | 0 | 0.85 |
| 14 |  | J. Smoltz | 418 | 514 | 198 | 20 | 459 | 2 | 1 | 0.91 |
| 15 | | C. Finley | 408 | 444 | 273 | 34 | 588 | 1 | 1 | 0.69 |
| 16 | | M. Mussina | 407 | 493 | 244 | 31 | 398 | 1 | 0 | 1.02 |
| 17 |  | C. Kershaw | 404 | 419 | 175 | 25 | 358 | 0 | 0 | 1.13 |
| 18 | | J. Moyer | 399 | 598 | 339 | 48 | 472 | 1 | 0 | 0.85 |
| 19 | | D. Cone | 395 | 390 | 165 | 21 | 485 | 4 | 0 | 0.81 |
| 20 | | C. Schilling | 391 | 468 | 222 | 29 | 349 | 1 | 0 | 1.12 |
| 21 |  | B. Colon | 389 | 525 | 229 | 36 | 509 | 1 | 0 | 0.76 |
| 22 | | J. Quintana | 376 | 356 | 199 | 28 | 368 | 0 | 0 | 1.02 |
| 23 | | J. Vazquez | 376 | 427 | 219 | 38 | 376 | 1 | 0 | 1.00 |
| 24 |  | G. Cole | 373 | 311 | 145 | 17 | 316 | 1 | 3 | 1.18 |
| 25 |  | E. Santana | 373 | 396 | 206 | 35 | 373 | 3 | 0 | 1.00 |
StatMuse has event-level data for strikeouts going back to the 1974 season.
Some of the information used here was obtained free of charge from Retrosheet.
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