Nolan Ryan had the most games pitched when striking out 18+ batters, with 5 games.

most games with 18 or more strikeouts by a pitcher all-time

Interpreted as:

most regular-season games with 18 or more strikeouts by a pitcher all-time

NAME	G	SO	W	L	W%	GS	CG	SHO	IP	H	TBF	R	ER	HR	BB	IBB	HBP	WP	ERA	WHIP	K/9	H/9	BB/9	K/BB
Nolan Ryan	5	94	2	1	.667	5	3	0	52.0	28	217	9	8	1	31	1	0	3	1.38	1.13	16.27	4.85	5.37	3.03
Randy Johnson	4	76	1	1	.500	4	2	1	35.0	25	135	7	7	2	7	0	0	0	1.80	0.91	19.54	6.43	1.80	10.86
Roger Clemens	3	58	3	0	1.000	3	3	2	27.0	11	92	1	1	1	0	0	0	1	0.33	0.41	19.33	3.67	0.00
Sandy Koufax	2	36	2	0	1.000	2	2	0	18.0	13	72	4	4	2	6	0	0	0	2.00	1.06	18.00	6.50	3.00	6.00
Max Scherzer	1	20	1	0	1.000	1	1	0	9.0	6	33	2	2	2	0	0	0	0	2.00	0.67	20.00	6.00	0.00
Corey Kluber	1	18	1	0	1.000	1	0	0	8.0	1	26	0	0	0	0	0	1	0	0.00	0.13	20.25	1.13	0.00
Ben Sheets	1	18	1	0	1.000	1	1	0	9.0	3	31	1	1	1	1	0	0	0	1.00	0.44	18.00	3.00	1.00	18.00
Kerry Wood	1	20	1	0	1.000	1	1	1	9.0	1	29	0	0	0	0	0	1	0	0.00	0.11	20.00	1.00	0.00
David Cone	1	19	1	0	1.000	1	1	1	9.0	3	31	0	0	0	1	0	0	0	0.00	0.44	19.00	3.00	1.00	19.00
Ramon Martinez	1	18	1	0	1.000	1	1	1	9.0	3	31	0	0	0	1	0	0	0	0.00	0.44	18.00	3.00	1.00	18.00
Bill Gullickson	1	18	1	0	1.000	1	1	0	9.0	4	33	2	2	0	2	0	0	1	2.00	0.67	18.00	4.00	2.00	9.00
Ron Guidry	1	18	1	0	1.000	1	1	1	9.0	4	33	0	0	0	2	0	0	0	0.00	0.67	18.00	4.00	2.00	9.00
Tom Seaver	1	19	1	0	1.000	1	1	0	9.0	2	31	1	1	1	2	0	0	0	1.00	0.44	19.00	2.00	2.00	9.50
Steve Carlton	1	19	0	1	.000	1	1	0	9.0	9	38	4	4	2	2	0	0	1	4.00	1.22	19.00	9.00	2.00	9.50
Don Wilson	1	18	1	0	1.000	1	1	0	9.0	5	33	1	1	0	2	0	0	1	1.00	0.78	18.00	5.00	2.00	9.00
Luis Tiant	1	19	1	0	1.000	1	1	1	10.0	6	36	0	0	0	0	0	0	0	0.00	0.60	17.10	5.40	0.00
Chris Short	1	18	0	0		1	0	0	15.0	9	56	0	0	0	3	1	0	0	0.00	0.80	10.80	5.40	1.80	6.00
Jim Maloney	1	18	0	1	.000	1	1	0	11.0	2	35	1	1	1	1	0	0	1	0.82	0.27	14.73	1.64	0.82	18.00
Tom Cheney	1	21	1	0	1.000	1	1	0	16.0	10	62	1	1	0	4	0	0	1	0.56	0.88	11.81	5.63	2.25	5.25
Warren Spahn	1	18	0	1	.000	1	1	0	15.0	10	57	3	3	1	2	1	0	0	1.80	0.80	10.80	6.00	1.20	9.00
Bob Feller	1	18	0	1	.000	1	1	0	9.0	7	42	4	4	0	7		1	0	4.00	1.56	18.00	7.00	7.00	2.57
Jack Coombs	1	18	0	0		1	1	1	16.0	3	54	0		0	6		1	1		0.56	10.13	1.69	3.38	3.00

StatMuse has game-level data for games pitched going back to the 1908 season.

Some of the information used here was obtained free of charge from Retrosheet.

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Sat 5/18	LAA	@	TEX	7:15 PM
Sun 5/19	LAA	@	TEX	2:35 PM
Mon 5/20	LAA	@	HOU	8:10 PM
Tue 5/21	LAA	@	HOU	8:10 PM
Wed 5/22	LAA	@	HOU	2:10 PM

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1	Braves	104	58	.642
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1	Orioles	101	61	.623
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2	Cubs	83	79	.512	9.0
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1	Astros	90	72	.556
2	Rangers	90	72	.556
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