Roger Clemens had the most games pitched when facing 25+ batters, with 618 games.

Interpreted as:

most regular-season games by a player with 25+ tbf

	NAME	G	TBF	W	L	W%	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Roger Clemens R. Clemens	618	18,452	335	149	.692	618	2.86	4,306	118	46	0	4513.2	3,739	1,434	1,592	305	1,422	141	0	59	125	8.59	2.84	3.03	0.61	23.3	7.7	1.14	.280	3.17	7.46
2	Nolan Ryan N. Ryan	604	19,171	289	209	.580	604	2.69	4,988	222	61	0	4642.2	3,223	1,386	1,600	237	2,275	130	0	67	229	9.67	4.41	2.19	0.46	26.0	11.9	1.18	.259	3.10	6.25
3	Don Sutton D. Sutton	600	18,415	302	173	.636	600	2.65	3,123	178	58	0	4578.1	3,795	1,348	1,490	345	1,098	61	0	80	90	6.14	2.16	2.84	0.68	17.0	6.0	1.07	.250	2.93	7.46
4	Phil Niekro P. Niekro	598	19,180	289	194	.598	598	2.86	2,933	244	45	0	4655.2	4,061	1,480	1,709	373	1,487	99	0	67	179	5.67	2.87	1.97	0.72	15.3	7.8	1.19	.258	3.30	7.85
5	Steve Carlton S. Carlton	592	19,065	318	176	.644	592	2.77	3,736	253	55	0	4656.1	3,957	1,434	1,638	320	1,571	43	0	136	157	7.22	3.04	2.38	0.62	19.6	8.2	1.19	.272	3.17	7.65
6	Gaylord Perry G. Perry	588	19,268	295	192	.606	585	2.59	3,123	302	53	0	4781.2	4,109	1,377	1,604	312	1,179	94	1	131	125	5.88	2.22	2.65	0.59	16.2	6.1	1.11	.261	3.02	7.73
7	Bert Blyleven B. Blyleven	570	18,102	266	193	.580	569	2.81	3,342	242	60	0	4451.0	3,926	1,389	1,569	341	1,150	138	0	56	93	6.76	2.33	2.91	0.69	18.5	6.4	1.14	.273	3.17	7.94
8	Warren Spahn W. Spahn	566	19,231	355	164	.684	566	2.54	2,346	381	63	0	4762.0	4,104	1,342	1,511	344	1,234	33	0	46	68	4.43	2.33	1.90	0.65	12.2	6.4	1.12	.246	2.86	7.76
9	Greg Maddux G. Maddux	559	16,579	279	166	.627	559	2.80	2,777	108	34	0	4094.1	3,737	1,275	1,461	257	800	117	0	147	52	6.10	1.76	3.47	0.56	16.8	4.8	1.11	.276	3.21	8.21
10	Tom Seaver T. Seaver	550	17,439	297	147	.669	550	2.39	3,365	230	61	0	4377.2	3,394	1,163	1,297	303	1,207	71	0	102	101	6.92	2.48	2.79	0.62	19.3	6.9	1.05	.247	2.67	6.98
11	Tom Glavine T. Glavine	543	15,742	267	149	.642	543	3.01	2,236	54	24	0	3777.1	3,504	1,265	1,407	269	1,235	51	0	128	53	5.33	2.94	1.81	0.64	14.2	7.8	1.25	.271	3.35	8.35
12	Tommy John T. John	509	15,784	266	137	.660	509	2.49	1,830	162	46	0	3881.2	3,583	1,074	1,265	201	944	69	0	81	123	4.24	2.19	1.94	0.47	11.6	6.0	1.17	.265	2.93	8.31
13	Robin Roberts R. Roberts	506	16,872	269	179	.600	505	2.85	2,121	301	45	0	4191.0	3,818	1,328	1,463	392	778	48	0	54	28	4.55	1.67	2.73	0.84	12.6	4.6	1.10	.253	3.14	8.20
14	Fergie Jenkins F. Jenkins	497	16,011	269	167	.617	495	2.83	2,850	267	49	0	3981.0	3,452	1,254	1,405	394	821	73	1	91	55	6.44	1.86	3.47	0.89	17.8	5.1	1.07	.258	3.18	7.80
15	Early Wynn E. Wynn	493	16,812	284	161	.638	490	2.84	2,061	289	49	0	4052.0	3,485	1,277	1,450	251	1,480	49	2	28	43	4.58	3.29	1.39	0.56	12.3	8.8	1.23	.249	3.22	7.74
16	Randy Johnson R. Johnson	483	14,425	255	122	.676	483	2.90	4,225	100	37	0	3531.1	2,770	1,138	1,285	315	1,208	162	0	29	85	10.77	3.08	3.50	0.80	29.3	8.4	1.13	.288	3.27	7.06
17	Frank Tanana F. Tanana	478	14,806	219	162	.575	478	2.84	2,376	143	34	0	3610.0	3,186	1,139	1,306	330	1,004	102	0	92	93	5.92	2.50	2.37	0.82	16.0	6.8	1.16	.260	3.26	7.94
18	Jamie Moyer J. Moyer	470	13,323	215	136	.613	469	3.64	1,888	33	10	0	3178.2	3,151	1,285	1,389	359	840	114	0	48	35	5.35	2.38	2.25	1.02	14.2	6.3	1.26	.276	3.93	8.92
19	Red Ruffing R. Ruffing	464	16,339	260	167	.609	457	3.34	1,779	333	44	0	3896.1	3,638	1,448	1,653	213	1,322	41	6		40	4.11	3.05	1.35	0.49	10.9	8.1	1.27	.264	3.82	8.40
20	Burleigh Grimes B. Grimes	455	16,139	246	157	.610	443	3.19	1,375	313	35	0	3795.2	3,896	1,346	1,696	123	1,120	88	9		73	3.26	2.66	1.23	0.29	8.5	6.9	1.32	.281	4.02	9.24
21	Jim Kaat J. Kaat	447	14,101	247	120	.673	444	2.55	1,948	180	31	0	3470.2	3,179	984	1,171	255	710	88	2	58	88	5.05	1.84	2.74	0.66	13.8	5.0	1.12	.263	3.04	8.24
22	Jack Morris J. Morris	442	14,142	241	137	.638	442	3.26	2,246	175	28	0	3427.2	2,954	1,240	1,375	312	1,179	48	0	82	175	5.90	3.10	1.91	0.82	15.9	8.3	1.21	.255	3.61	7.76
23	Ted Lyons T. Lyons	440	16,021	245	176	.582	434	3.17	995	356	27	0	3811.2	3,909	1,344	1,642	188	945	28	5		40	2.35	2.23	1.05	0.44	6.2	5.9	1.27	.268	3.88	9.23
24	Bob Gibson B. Gibson	439	14,844	241	146	.623	438	2.60	2,927	255	56	0	3631.0	2,958	1,048	1,194	221	1,168	95	0	103	92	7.26	2.90	2.51	0.55	19.7	7.9	1.14	.262	2.96	7.33
25	Jim Palmer J. Palmer	433	14,130	250	112	.691	430	2.36	1,953	210	52	0	3525.1	2,818	925	1,022	234	1,073	31	3	31	69	4.99	2.74	1.82	0.60	13.8	7.6	1.10	.238	2.61	7.19