Ted Lyons had the most games pitched when facing 40+ batters, with 101 games.

Interpreted as:

most regular-season games by a player with 40+ tbf

	NAME	G	TBF	W	L	W%	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Ted Lyons T. Lyons	101	4,416	50	49	.505	101	3.95	301	94	0	0	969.0	1,179	425	544	43	337	10	0		14	2.80	3.13	0.89	0.40	6.8	7.6	1.56	.305	5.05	10.95
2	Burleigh Grimes B. Grimes	93	4,046	58	31	.652	92	3.56	332	82	0	0	875.0	1,066	346	474	32	349	27	1		17	3.41	3.59	0.95	0.33	8.2	8.6	1.62	.313	4.88	10.96
3	Wes Ferrell W. Ferrell	78	3,349	55	22	.714	77	3.74	274	74	1	0	726.2	860	302	368	22	331	6	1		4	3.39	4.10	0.83	0.27	8.2	9.9	1.64	.309	4.56	10.65
4	Bobo Newsom B. Newsom	75	3,215	33	33	.500	75	4.58	384	59	0	0	696.0	773	354	389	40	392	13	0		13	4.97	5.07	0.98	0.52	11.9	12.2	1.67	.307	5.03	10.00
5	Red Ruffing R. Ruffing	75	3,273	34	39	.466	75	4.51	345	69	0	0	719.2	838	361	404	42	308	11	0		10	4.31	3.85	1.12	0.53	10.5	9.4	1.59	.310	5.05	10.48
6	Earl Whitehill E. Whitehill	72	3,124	47	21	.691	72	3.93	253	63	1	0	689.0	805	301	347	23	277	25	0		11	3.30	3.62	0.91	0.30	8.1	8.9	1.57	.307	4.53	10.52
7	Lefty Grove L. Grove	68	3,011	45	20	.692	67	3.37	376	62	2	0	676.1	728	253	292	32	266	7	1		4	5.00	3.54	1.41	0.43	12.5	8.8	1.47	.299	3.89	9.69
8	Howard Ehmke H. Ehmke	64	2,779	32	31	.508	64	4.05	231	59	0	0	604.2	699	272	348	19	252	40	0		8	3.44	3.75	0.92	0.28	8.3	9.1	1.57	.304	5.18	10.40
9	George Uhle G. Uhle	59	2,575	28	29	.491	59	3.86	190	52	0	0	560.0	683	240	301	14	193	28	0		10	3.05	3.10	0.98	0.23	7.4	7.5	1.56	.311	4.84	10.98
10	Jimmy Ring J. Ring	55	2,384	27	24	.529	55	3.63	165	47	0	0	531.0	590	214	278	15	228	7	0		20	2.80	3.86	0.72	0.25	6.9	9.6	1.54	.292	4.71	10.00
11	Carl Hubbell C. Hubbell	54	2,313	32	21	.604	53	3.14	238	49	2	0	527.0	569	184	217	28	145	14	1		9	4.06	2.48	1.64	0.48	10.3	6.3	1.35	.287	3.71	9.72
12	Sad Sam Jones S. Sam Jones	54	2,287	24	28	.462	54	3.68	157	48	2	0	504.0	591	206	267	17	198	10	0		10	2.80	3.54	0.79	0.30	6.9	8.7	1.57	.301	4.77	10.55
13	Bucky Walters B. Walters	53	2,268	32	18	.640	53	2.52	173	45	2	0	524.0	521	147	180	26	226	4	0		11	2.97	3.88	0.77	0.45	7.6	10.0	1.43	.269	3.09	8.95
14	Red Faber R. Faber	53	2,311	30	20	.600	53	3.45	175	49	0	0	516.1	618	198	252	21	158	9	0		10	3.05	2.75	1.11	0.37	7.6	6.8	1.50	.306	4.39	10.77
15	Bob Feller B. Feller	49	2,088	29	14	.674	49	3.67	330	38	2	0	455.2	445	186	207	22	287	9	0	0	14	6.52	5.67	1.15	0.43	15.8	13.7	1.61	.294	4.09	8.79
16	Paul Derringer P. Derringer	49	2,090	21	26	.447	49	3.14	168	43	0	0	473.0	571	165	202	15	117	4	0		12	3.20	2.23	1.44	0.29	8.0	5.6	1.45	.311	3.84	10.86
17	Wilbur Cooper W. Cooper	49	2,126	31	16	.660	49	2.82	177	48	1	0	497.1	509	156	180	18	146	19	0		7	3.20	2.64	1.21	0.33	8.3	6.9	1.32	.278	3.26	9.21
18	Eppa Rixey E. Rixey	49	2,192	27	22	.551	49	2.90	176	44	0	0	508.1	547	164	213	15	150	12	0		13	3.12	2.66	1.17	0.27	8.0	6.8	1.37	.289	3.77	9.68
19	Walter Johnson W. Johnson	49	2,206	24	23	.511	49	2.88	236	48	4	0	519.1	515	166	200	9	160	17	0		10	4.09	2.77	1.48	0.16	10.7	7.3	1.30	.284	3.47	8.92
20	Clarence Mitchell C. Mitchell	48	2,039	30	16	.652	48	3.53	114	42	0	0	459.0	552	180	226	17	130	9	0		10	2.24	2.55	0.88	0.33	5.6	6.4	1.49	.302	4.43	10.82
21	Early Wynn E. Wynn	46	1,954	22	23	.489	46	3.55	173	38	0	0	436.0	470	172	208	27	185	8	0	4	1	3.57	3.82	0.94	0.56	8.9	9.5	1.50	.284	4.29	9.70
22	Tom Zachary T. Zachary	46	1,952	24	18	.571	46	3.27	98	38	1	0	434.1	508	158	189	19	157	7	0		4	2.03	3.25	0.62	0.39	5.0	8.0	1.53	.293	3.92	10.53
23	Herb Pennock H. Pennock	45	1,951	32	11	.744	44	3.70	148	41	1	0	438.0	532	180	209	16	133	6	1		5	3.04	2.73	1.11	0.33	7.6	6.8	1.52	.313	4.29	10.93
24	Bill Sherdel B. Sherdel	45	1,914	29	14	.674	43	4.21	144	38	0	0	425.2	527	199	235	24	127	5	2		8	3.04	2.69	1.13	0.51	7.5	6.6	1.54	.312	4.97	11.14
25	Carl Mays C. Mays	45	1,945	25	13	.658	44	3.25	118	37	0	0	437.1	503	158	214	12	142	13	1		6	2.43	2.92	0.83	0.25	6.1	7.3	1.47	.296	4.40	10.35