Barry Bonds has launched the most career home runs before the 4th inning, with 296 homers.

Interpreted as:

most hr by a player before the 4th inning, all-time

	NAME	HR	G	AB	H	2B	3B	RBI	BB	HBP	SO	PA	TB	XBH	SH	SF	IBB	AVG	OBP	SLG	OPS
1	Barry Bonds B. Bonds	296	2,848	3,610	1,106	216	30	822	941	49	540	4,635	2,270	542	1	34	216	.306	.452	.629	1.081
2	Albert Pujols A. Pujols	259	2,961	4,198	1,235	271	5	899	445	35	508	4,743	2,293	535	0	65	48	.294	.362	.546	.908
3	Alex Rodriguez A. Rodriguez	253	2,733	3,880	1,123	197	4	792	535	68	863	4,538	2,087	454	9	46	14	.289	.381	.538	.919
4	Frank Thomas F. Thomas	224	2,278	3,021	940	191	6	728	619	34	486	3,733	1,815	421	0	59	31	.311	.427	.601	1.028
5	Sammy Sosa S. Sosa	221	2,265	3,096	851	135	15	611	345	19	850	3,495	1,679	371	3	32	25	.275	.348	.542	.890
6	Ken Griffey Jr. K. Griffey Jr.	220	2,547	3,615	1,026	188	11	718	487	34	681	4,184	1,896	419	1	47	33	.284	.370	.524	.894
7	Jim Thome J. Thome	213	2,371	2,857	793	153	10	662	575	19	816	3,483	1,605	376	0	32	29	.278	.398	.562	.960
8	Mark McGwire M. McGwire	213	1,784	2,163	570	99	2	552	441	31	549	2,667	1,312	314	0	32	27	.264	.391	.607	.997
9	Gary Sheffield G. Sheffield	208	2,505	3,422	1,034	179	12	729	547	55	462	4,075	1,861	399	2	49	14	.302	.402	.544	.946
10	Rafael Palmeiro R. Palmeiro	196	2,714	3,781	1,109	234	17	718	463	42	475	4,341	1,965	447	0	55	26	.293	.372	.520	.892
11	Miguel Cabrera M. Cabrera	193	2,766	3,758	1,154	217	9	748	456	31	770	4,297	1,968	419	1	51	41	.307	.382	.524	.906
12	Manny Ramirez M. Ramirez	186	2,240	2,908	902	199	7	725	443	46	642	3,440	1,673	392	0	43	42	.310	.404	.575	.980
13	Mike Schmidt M. Schmidt	185	2,210	2,812	772	157	20	617	481	30	659	3,369	1,524	362	3	43	25	.275	.381	.542	.923
14	Carlos Delgado C. Delgado	181	1,976	2,489	717	169	4	643	381	70	624	2,992	1,437	354	0	52	23	.288	.390	.577	.968
15	Eddie Murray E. Murray	181	2,972	3,839	1,078	195	6	746	470	6	522	4,364	1,828	382	0	49	42	.281	.356	.476	.832
16	Adam Dunn A. Dunn	180	1,931	2,347	576	113	4	453	443	29	805	2,834	1,237	297	0	15	19	.245	.370	.527	.897
17	David Ortiz D. Ortiz	180	2,274	3,050	909	256	9	684	490	11	625	3,591	1,723	445	0	40	35	.298	.393	.565	.958
18	Giancarlo Stanton G. Stanton	178	1,658	2,156	569	107	6	461	320	24	677	2,515	1,222	291	0	14	12	.264	.363	.567	.930
19	Fred McGriff F. McGriff	176	2,382	2,957	869	153	5	656	446	16	590	3,457	1,560	334	0	38	26	.294	.385	.528	.913
20	Mike Trout M. Trout	175	1,630	2,429	721	133	21	414	365	43	681	2,863	1,421	329	0	25	18	.297	.394	.585	.979
21	Chipper Jones C. Jones	174	2,398	3,350	1,032	212	18	664	566	6	555	3,964	1,802	404	0	42	17	.308	.405	.538	.943
22	Adrian Beltre A. Beltre	173	2,870	3,708	1,101	230	16	665	277	30	620	4,061	1,882	419	2	44	15	.297	.347	.508	.854
23	Jose Canseco J. Canseco	169	1,832	2,543	676	119	7	536	367	27	704	2,969	1,316	295	1	31	8	.266	.361	.517	.878
24	Dave Winfield D. Winfield	167	2,795	3,643	1,064	196	36	752	462	5	570	4,153	1,833	399	2	41	33	.292	.369	.503	.872
25	Alfonso Soriano A. Soriano	166	1,907	2,852	767	172	11	414	148	44	625	3,065	1,459	349	1	20	9	.269	.313	.512	.825

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StatMuse has event-level data for home runs going back to the 1974 season.

Some of the information used here was obtained free of charge from Retrosheet.

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Wed 3/25	NYY	@	SFG	8:05 PM
Fri 3/27	NYY	@	SFG	4:35 PM
Sat 3/28	NYY	@	SFG	7:15 PM
Mon 3/30	SFG	@	SDP	9:40 PM
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