Between the 2000 and 2009 seasons, Mark Buehrle had the most no-hitters, with 2.

Interpreted as:

most regular-season no-hitters by pitcher 2000 to 2009

	NAME	NH	G	W	L	W%	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Mark Buehrle M. Buehrle	2	326	135	97	.582	301	3.80	1,188	24	8	0	2061.0	2,143	871	973	236	470	52	6	35	8,562	17	5.19	2.05	2.53	1.03	13.9	5.5	1.27	.288	4.25	9.36
2	Clay Buchholz C. Buchholz	1	36	12	14	.462	34	4.91	162	2	1	0	190.2	198	104	113	24	87	5	0	2	844	3	7.65	4.11	1.86	1.13	19.2	10.3	1.49	.307	5.33	9.35
3	Anibal Sanchez A. Sanchez	1	50	18	17	.514	49	3.86	207	2	1	0	282.0	271	121	130	29	138	13	0	9	1,244	8	6.61	4.40	1.50	0.93	16.6	11.1	1.45	.282	4.15	8.65
4	Jon Lester J. Lester	1	92	42	16	.724	91	3.66	487	4	2	0	558.0	540	227	234	51	204	19	0	2	2,359	15	7.85	3.29	2.39	0.82	20.6	8.6	1.33	.306	3.77	8.71
5	Jonathan Sanchez J. Sanchez	1	121	21	30	.412	66	4.81	429	1	1	0	413.1	385	221	232	43	214	22	14	7	1,828	24	9.34	4.66	2.00	0.94	23.5	11.7	1.45	.305	5.05	8.38
6	Justin Verlander J. Verlander	1	132	65	43	.602	132	3.92	746	6	3	0	840.0	797	366	393	80	282	46	0	17	3,558	37	7.99	3.02	2.65	0.86	21.0	7.9	1.28	.298	4.21	8.54
7	Carlos Zambrano C. Zambrano	1	259	105	68	.607	238	3.51	1,324	9	4	0	1551.1	1,313	605	669	126	698	81	4	36	6,593	49	7.68	4.05	1.90	0.73	20.1	10.6	1.30	.272	3.88	7.62
8	Bud Smith B. Smith	1	27	7	8	.467	24	4.95	81	1	1	0	132.2	146	73	79	16	46	4	2	7	580	0	5.49	3.12	1.76	1.09	14.0	7.9	1.45	.300	5.36	9.90
9	A.J. Burnett	1	241	96	83	.536	237	3.85	1,440	20	9	0	1542.0	1,355	660	721	144	640	70	1	21	6,531	83	8.40	3.74	2.25	0.84	22.0	9.8	1.29	.286	4.21	7.91
10	Kevin Millwood K. Millwood	1	307	115	103	.528	305	4.18	1,398	15	4	0	1860.2	1,923	865	937	201	578	56	0	35	7,982	41	6.76	2.80	2.42	0.97	17.5	7.2	1.34	.300	4.53	9.30
11	Randy Johnson R. Johnson	1	287	143	78	.647	281	3.34	2,182	32	12	0	1885.1	1,616	699	790	212	484	89	3	22	7,686	34	10.42	2.31	4.51	1.01	28.4	6.3	1.11	.298	3.77	7.71
12	Derek Lowe D. Lowe	1	410	130	99	.568	270	3.81	1,177	9	3	66	1833.2	1,863	776	885	149	519	54	115	39	7,746	32	5.78	2.55	2.27	0.73	15.2	6.7	1.30	.293	4.34	9.14
13	Hideo Nomo H. Nomo	1	172	62	60	.508	168	4.64	887	5	4	0	1015.2	968	524	549	145	481	15	2	17	4,392	46	7.86	4.26	1.84	1.28	20.2	11.0	1.43	.287	4.86	8.58