Rickey Henderson has the most career runs, with 2,295 runs.

	NAME	R	G	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS	WRC	WRAA	WOBA	WRC+	BRAA
1	Rickey Henderson R. Henderson	2,295	3,081	10,961	3,055	510	66	297	1,115	2,190	98	1,694	1,406	335	13,346	4,588	873	30	67	61	172	.279	.401	.419	.820	2074	509.6	.372	132	507.9
2	Ty Cobb T. Cobb	2,244	3,034	11,434	4,189	724	295	117	1,933	1,249	94	681	897		13,068	5,854	1,136	291				.366	.433	.512	.945	2534	1,093.6	.445	165	975.1
3	Barry Bonds B. Bonds	2,227	2,986	9,847	2,935	601	77	762	1,996	2,558	106	1,539	514	141	12,606	5,976	1,440	4	91	688	165	.298	.444	.607	1.051	2663	1,143.3	.435	172	1,142
4	Hank Aaron H. Aaron	2,174	3,298	12,364	3,771	624	98	755	2,297	1,402	32	1,383	240	73	13,940	6,856	1,477	21	121	293	328	.305	.374	.555	.928	2453	936.4	.403	153	858.5
5	Babe Ruth B. Ruth	2,174	2,503	8,399	2,873	506	136	714	2,214	2,062	43	1,330	123		10,617	5,793	1,356	113				.342	.474	.690	1.164	2727	1,436.8	.513	197	1,369.6
6	Pete Rose P. Rose	2,165	3,562	14,053	4,256	746	135	160	1,314	1,566	107	1,143	198	149	15,861	5,752	1,041	56	79	167	247	.303	.375	.409	.784	2190	480.1	.354	121	368.7
7	Willie Mays W. Mays	2,062	2,992	10,881	3,283	523	140	660	1,903	1,464	44	1,526	338	103	12,493	6,066	1,323	13	91	192	251	.302	.384	.557	.941	2266	894.8	.409	154	802.7
8	Alex Rodriguez A. Rodriguez	2,021	2,784	10,566	3,115	548	31	696	2,086	1,338	176	2,287	329	76	12,207	5,813	1,275	16	111	97	261	.295	.380	.550	.930	2178	690.1	.395	141	629.5
9	Stan Musial S. Musial	1,949	3,026	10,972	3,630	725	177	475	1,951	1,599	53	696	78	31	12,712	6,134	1,377	35	53	127	243	.331	.417	.559	.976	2474	1,032.5	.435	158	896.7
10	Derek Jeter D. Jeter	1,923	2,747	11,195	3,465	544	66	260	1,311	1,082	170	1,840	358	97	12,602	4,921	870	97	58	39	287	.310	.377	.440	.817	1877	346.6	.360	119	305.9
11	Albert Pujols A. Pujols	1,914	3,080	11,421	3,384	686	16	703	2,218	1,373	123	1,404	117	43	13,041	6,211	1,405	1	123	316	426	.296	.374	.544	.918	2233	685	.385	141	673
12	Lou Gehrig L. Gehrig	1,888	2,164	8,001	2,721	534	163	493	1,995	1,508	45	790	102		9,660	5,060	1,190	106			2	.340	.447	.632	1.080	2265	1,046.8	.477	173	980
13	Tristram Speaker T. Speaker	1,882	2,789	10,195	3,514	792	222	117	1,531	1,381	103	394	436		11,988	5,101	1,131	309				.345	.428	.500	.928	2264	921	.436	157	812.3
14	Mel Ott M. Ott	1,859	2,730	9,456	2,876	488	72	511	1,860	1,708	64	896	89		11,337	5,041	1,071	109			38	.304	.414	.533	.947	2204	826.4	.430	156	794.2
15	Craig Biggio C. Biggio	1,844	2,850	10,876	3,060	668	55	291	1,175	1,160	285	1,753	414	124	12,503	4,711	1,014	101	81	68	150	.281	.363	.433	.796	1768	248.9	.352	115	238.9
16	Frank Robinson F. Robinson	1,829	2,808	10,006	2,943	528	72	586	1,812	1,420	198	1,532	204	77	11,743	5,373	1,186	17	102	218	270	.294	.389	.537	.926	2083	807.2	.404	153	717.1
17	Eddie Collins E. Collins	1,821	2,826	9,949	3,315	438	187	47	1,300	1,499	77	468	741		12,037	4,268	672	512				.333	.424	.429	.853	2032	693.4	.409	144	619.7
18	Carl Yastrzemski C. Yastrzemski	1,816	3,308	11,988	3,419	646	59	452	1,844	1,845	40	1,393	168	116	13,991	5,539	1,157	13	105	190	323	.285	.379	.462	.841	2155	643.2	.375	130	469.8
19	Ted Williams T. Williams	1,798	2,292	7,706	2,654	525	71	521	1,839	2,021	39	709	24	4	9,791	4,884	1,117	5	20	86	197	.344	.482	.634	1.116	2349	1,219.7	.493	188	1,067
20	Paul Molitor P. Molitor	1,782	2,683	10,835	3,319	605	114	234	1,307	1,094	47	1,244	504	131	12,160	4,854	953	75	109	100	209	.306	.369	.448	.817	1785	375.3	.361	122	319.5
21	Charlie Gehringer C. Gehringer	1,775	2,323	8,860	2,839	574	146	184	1,427	1,186	50	372	181		10,237	4,257	904	141			27	.320	.404	.480	.884	1797	516.6	.405	124	350
22	Jimmie Foxx J. Foxx	1,751	2,317	8,134	2,646	458	125	534	1,922	1,452	13	1,311	87		9,670	4,956	1,117	71			69	.325	.428	.609	1.038	2135	934.1	.460	158	780.8
23	Honus Wagner H. Wagner	1,739	2,794	10,439	3,420	643	252	101	1,732	963	125	735	723		11,748	4,870	996	221				.328	.391	.467	.858	2044	725.8	.408	147	650
24	Cap Anson C. Anson	1,722	2,277	9,104	3,012	529	124	97	1,306	953	32	146	247		10,123	4,080	750	34				.331	.396	.448	.844	2154	654.1	.397	134	525.3
25	Jesse Burkett J. Burkett	1,720	2,067	8,426	2,850	320	182	75	952	1,029	75	561	389		9,620	3,759	577	90				.338	.415	.446	.861	1921	592.9	.411	137	526.7