Before April 21, 2017, Rickey Henderson had the most runs, with 2,295 runs.

Interpreted as:

most runs by a player through april 20, 2017

	NAME	R	G	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Rickey Henderson R. Henderson	2,295	3,081	10,961	3,055	510	66	297	1,115	2,190	98	1,694	1,406	335	13,346	4,588	873	30	67	61	172	.279	.401	.419	.820
2	Ty Cobb T. Cobb	2,246	3,032	11,443	4,189	723	298	117		1,261	95		900		13,090	5,859	1,138	296				.366		.512
3	Barry Bonds B. Bonds	2,227	2,986	9,847	2,935	601	77	762	1,996	2,558	106	1,539	514	141	12,606	5,976	1,440	4	91	688	165	.298	.444	.607	1.051
4	Hank Aaron H. Aaron	2,175	3,298	12,364	3,771	624	98	755	2,297	1,403	32	1,381	240	73	13,941	6,856	1,477	21	121	293	330	.305	.374	.555	.929
5	Babe Ruth B. Ruth	2,173	2,504	8,400	2,873	506	136	714	2,213	2,062	44	1,331	123		10,622	5,793	1,356	116				.342	.474	.690	1.164
6	Pete Rose P. Rose	2,165	3,562	14,053	4,256	746	135	160	1,314	1,566	107	1,143	198	148	15,861	5,752	1,041	56	79	167	250	.303	.375	.409	.784
7	Willie Mays W. Mays	2,060	2,992	10,881	3,283	523	140	660	1,903	1,467	44	1,527	338	102	12,496	6,066	1,323	13	91	193	253	.302	.384	.557	.942
8	Alex Rodriguez A. Rodriguez	2,021	2,784	10,566	3,115	548	31	696	2,086	1,338	176	2,287	329	76	12,207	5,813	1,275	16	111	97	261	.295	.380	.550	.930
9	Stan Musial S. Musial	1,949	3,026	10,971	3,630	726	177	475	1,950	1,605	53	698	78	31	12,718	6,135	1,378	36	53	127	249	.331	.417	.559	.976
10	Derek Jeter D. Jeter	1,923	2,747	11,195	3,465	544	66	260	1,311	1,082	170	1,840	358	97	12,602	4,921	870	97	58	39	287	.310	.377	.440	.817
11	Lou Gehrig L. Gehrig	1,888	2,164	8,001	2,721	534	163	493	1,998	1,511	46	789	102		9,664	5,060	1,190	106			2	.340	.448	.632	1.080
12	Tristram Speaker T. Speaker	1,881	2,792	10,199	3,515	794	221	117		1,393	105		437		12,011	5,102	1,132	314				.345	.429	.500	.929
13	Mel Ott M. Ott	1,859	2,730	9,455	2,876	488	72	511	1,865	1,720	64	895	89		11,348	5,041	1,071	109			38	.304	.415	.533	.948
14	Craig Biggio C. Biggio	1,844	2,850	10,876	3,060	668	55	291	1,175	1,160	285	1,753	414	124	12,503	4,711	1,014	101	81	68	150	.281	.363	.433	.796
15	Frank Robinson F. Robinson	1,830	2,808	10,006	2,943	528	72	586	1,812	1,418	198	1,532	203	79	11,741	5,373	1,186	17	102	218	279	.294	.389	.537	.926
16	Eddie Collins E. Collins	1,822	2,825	9,955	3,311	438	187	47		1,533	77		741		12,081	4,264	672	516				.333	.426	.428	.854
17	Carl Yastrzemski C. Yastrzemski	1,816	3,308	11,988	3,419	646	59	452	1,844	1,845	40	1,395	168	115	13,991	5,539	1,157	13	105	190	325	.285	.379	.462	.841
18	Ted Williams T. Williams	1,799	2,292	7,706	2,654	525	71	521	1,839	2,018	39	709	24	5	9,788	4,884	1,117	5	20	89	201	.344	.482	.634	1.115
19	Paul Molitor P. Molitor	1,782	2,683	10,835	3,319	605	114	234	1,307	1,094	47	1,244	504	131	12,160	4,854	953	75	109	100	208	.306	.369	.448	.817
20	Charlie Gehringer C. Gehringer	1,775	2,323	8,860	2,839	574	146	184	1,434	1,193	51	372	182		10,244	4,257	904	140			27	.320	.404	.480	.885
21	Jimmie Foxx J. Foxx	1,751	2,317	8,134	2,645	458	125	534	1,924	1,457	13	1,311	87		9,676	4,955	1,117	72			70	.325	.428	.609	1.038
22	Mickey Mantle M. Mantle	1,675	2,401	8,101	2,415	344	72	536	1,509	1,733	12	1,718	152	42	9,907	4,511	952	14	47	126	113	.298	.420	.557	.977
23	Albert Pujols A. Pujols	1,674	2,442	9,200	2,836	603	16	593	1,828	1,218	100	1,064	107	41	10,618	5,250	1,212	1	99	303	338	.308	.391	.571	.962
24	Dave Winfield D. Winfield	1,669	2,973	11,003	3,110	540	88	465	1,833	1,216	25	1,686	223	96	12,358	5,221	1,093	19	95	172	319	.283	.353	.475	.827
25	Johnny Damon J. Damon	1,668	2,490	9,736	2,769	522	109	235	1,139	1,003	50	1,257	408	103	10,917	4,214	866	57	71	38	93	.284	.352	.433	.785