Between April 17, 1991 and September 25, 2018, Randy Johnson fanned the most hitters, with 4,514 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | R. Johnson | 4,514 | 550 | 278 | 141 | .663 | 536 | 3.20 | 91 | 35 | 2 | 3714.2 | 2,989 | 1,322 | 1,483 | 368 | 1,264 | 182 | 6 | 33 | 15,237 | 94 | 10.94 | 3.06 | 3.57 | 0.89 | 29.6 | 8.3 | 1.14 | .294 | 3.59 | 7.24 |
| 2 |  | R. Clemens | 3,231 | 501 | 236 | 133 | .640 | 500 | 3.24 | 52 | 20 | 0 | 3386.2 | 2,895 | 1,220 | 1,349 | 261 | 1,155 | 120 | 0 | 44 | 14,018 | 104 | 8.59 | 3.07 | 2.80 | 0.69 | 23.0 | 8.2 | 1.20 | .285 | 3.58 | 7.69 |
| 3 |  | P. Martinez | 3,154 | 476 | 219 | 100 | .687 | 409 | 2.93 | 46 | 17 | 3 | 2827.1 | 2,221 | 919 | 1,006 | 239 | 760 | 141 | 23 | 30 | 11,394 | 62 | 10.04 | 2.42 | 4.15 | 0.76 | 27.7 | 6.7 | 1.05 | .279 | 3.20 | 7.07 |
| 4 |  | C. Schilling | 3,067 | 521 | 215 | 140 | .606 | 431 | 3.43 | 83 | 20 | 17 | 3187.0 | 2,922 | 1,215 | 1,277 | 341 | 678 | 51 | 62 | 41 | 12,957 | 67 | 8.66 | 1.91 | 4.52 | 0.96 | 23.7 | 5.2 | 1.13 | .293 | 3.61 | 8.25 |
| 5 |  | CC Sabathia | 2,981 | 537 | 245 | 153 | .616 | 537 | 3.70 | 38 | 12 | 0 | 3465.0 | 3,291 | 1,426 | 1,559 | 355 | 1,060 | 118 | 0 | 44 | 14,503 | 74 | 7.74 | 2.75 | 2.81 | 0.92 | 20.6 | 7.3 | 1.26 | .294 | 4.05 | 8.55 |
| 6 |  | G. Maddux | 2,818 | 602 | 293 | 174 | .627 | 602 | 3.04 | 83 | 28 | 0 | 4082.1 | 3,799 | 1,381 | 1,544 | 296 | 676 | 113 | 0 | 123 | 16,462 | 53 | 6.21 | 1.49 | 4.17 | 0.65 | 17.1 | 4.1 | 1.10 | .279 | 3.40 | 8.38 |
| 7 | | M. Mussina | 2,813 | 537 | 270 | 153 | .638 | 536 | 3.68 | 57 | 23 | 0 | 3562.2 | 3,460 | 1,458 | 1,559 | 376 | 785 | 60 | 0 | 29 | 14,593 | 71 | 7.11 | 1.98 | 3.58 | 0.95 | 19.3 | 5.4 | 1.19 | .292 | 3.94 | 8.74 |
| 8 |  | J. Smoltz | 2,702 | 646 | 185 | 125 | .597 | 404 | 3.26 | 42 | 14 | 154 | 2958.1 | 2,624 | 1,073 | 1,158 | 242 | 812 | 52 | 204 | 75 | 12,114 | 120 | 8.22 | 2.47 | 3.33 | 0.74 | 22.3 | 6.7 | 1.16 | .287 | 3.52 | 7.98 |
| 9 |  | J. Verlander | 2,696 | 418 | 204 | 123 | .624 | 418 | 3.40 | 24 | 8 | 0 | 2753.0 | 2,395 | 1,039 | 1,124 | 272 | 807 | 92 | 0 | 27 | 11,325 | 82 | 8.81 | 2.64 | 3.34 | 0.89 | 23.8 | 7.1 | 1.16 | .285 | 3.67 | 7.83 |
| 10 | | J. Vazquez | 2,536 | 450 | 165 | 160 | .508 | 443 | 4.22 | 28 | 8 | 0 | 2840.0 | 2,784 | 1,331 | 1,431 | 373 | 763 | 88 | 5 | 58 | 11,935 | 76 | 8.04 | 2.42 | 3.32 | 1.18 | 21.2 | 6.4 | 1.25 | .295 | 4.53 | 8.82 |
| 11 |  | B. Colon | 2,535 | 565 | 247 | 188 | .568 | 552 | 4.12 | 38 | 13 | 0 | 3461.2 | 3,593 | 1,584 | 1,719 | 439 | 948 | 64 | 2 | 47 | 14,655 | 45 | 6.59 | 2.46 | 2.67 | 1.14 | 17.3 | 6.5 | 1.31 | .296 | 4.47 | 9.34 |
| 12 | | A.J. Burnett | 2,513 | 435 | 164 | 157 | .511 | 430 | 3.99 | 24 | 10 | 0 | 2731.1 | 2,519 | 1,210 | 1,328 | 263 | 1,100 | 143 | 1 | 35 | 11,665 | 161 | 8.28 | 3.62 | 2.28 | 0.87 | 21.5 | 9.4 | 1.32 | .295 | 4.38 | 8.30 |
| 13 |  | F. Hernandez | 2,463 | 403 | 168 | 127 | .569 | 402 | 3.33 | 25 | 11 | 0 | 2654.0 | 2,399 | 982 | 1,094 | 245 | 778 | 98 | 0 | 16 | 10,940 | 150 | 8.35 | 2.64 | 3.17 | 0.83 | 22.5 | 7.1 | 1.20 | .293 | 3.71 | 8.14 |
| 14 |  | M. Scherzer | 2,449 | 338 | 159 | 82 | .660 | 329 | 3.22 | 10 | 5 | 0 | 2117.2 | 1,739 | 757 | 817 | 236 | 585 | 78 | 2 | 17 | 8,585 | 65 | 10.41 | 2.49 | 4.19 | 1.00 | 28.5 | 6.8 | 1.10 | .287 | 3.47 | 7.39 |
| 15 | | A. Pettitte | 2,448 | 531 | 256 | 153 | .626 | 521 | 3.85 | 26 | 4 | 0 | 3316.0 | 3,448 | 1,418 | 1,572 | 288 | 1,031 | 55 | 3 | 42 | 14,074 | 69 | 6.64 | 2.80 | 2.37 | 0.78 | 17.4 | 7.3 | 1.35 | .308 | 4.27 | 9.36 |
| 16 |  | Z. Greinke | 2,429 | 454 | 186 | 118 | .612 | 413 | 3.39 | 16 | 5 | 1 | 2657.1 | 2,478 | 1,000 | 1,076 | 271 | 635 | 65 | 8 | 22 | 10,892 | 84 | 8.23 | 2.15 | 3.83 | 0.92 | 22.3 | 5.8 | 1.17 | .295 | 3.64 | 8.39 |
| 17 | | C. Hamels | 2,407 | 394 | 156 | 113 | .580 | 393 | 3.40 | 17 | 7 | 0 | 2546.0 | 2,277 | 963 | 1,034 | 293 | 708 | 91 | 0 | 42 | 10,456 | 56 | 8.51 | 2.50 | 3.40 | 1.04 | 23.0 | 6.8 | 1.17 | .285 | 3.66 | 8.05 |
| 18 | | J. Lackey | 2,294 | 448 | 188 | 147 | .561 | 446 | 3.92 | 18 | 8 | 0 | 2840.1 | 2,862 | 1,237 | 1,347 | 319 | 815 | 133 | 0 | 32 | 12,030 | 125 | 7.27 | 2.58 | 2.81 | 1.01 | 19.1 | 6.8 | 1.29 | .300 | 4.27 | 9.07 |
| 19 | | T. Glavine | 2,278 | 576 | 271 | 162 | .626 | 576 | 3.41 | 48 | 21 | 0 | 3761.1 | 3,633 | 1,425 | 1,555 | 301 | 1,284 | 52 | 0 | 121 | 15,803 | 52 | 5.45 | 3.07 | 1.77 | 0.72 | 14.4 | 8.1 | 1.31 | .280 | 3.72 | 8.69 |
| 20 |  | C. Kershaw | 2,271 | 317 | 153 | 69 | .689 | 315 | 2.38 | 25 | 15 | 0 | 2091.1 | 1,562 | 552 | 604 | 145 | 536 | 31 | 1 | 27 | 8,230 | 80 | 9.77 | 2.31 | 4.24 | 0.62 | 27.6 | 6.5 | 1.00 | .270 | 2.60 | 6.72 |
| 21 | | J. Shields | 2,234 | 407 | 145 | 139 | .511 | 405 | 4.01 | 23 | 9 | 0 | 2616.0 | 2,581 | 1,167 | 1,267 | 361 | 746 | 97 | 1 | 22 | 10,993 | 107 | 7.69 | 2.57 | 2.99 | 1.24 | 20.3 | 6.8 | 1.27 | .294 | 4.36 | 8.88 |
| 22 | | J. Peavy | 2,207 | 388 | 152 | 126 | .547 | 377 | 3.63 | 15 | 6 | 0 | 2377.0 | 2,134 | 960 | 1,011 | 259 | 708 | 78 | 3 | 42 | 9,838 | 46 | 8.36 | 2.68 | 3.12 | 0.98 | 22.4 | 7.2 | 1.20 | .285 | 3.83 | 8.08 |
| 23 |  | J. Lester | 2,187 | 380 | 176 | 98 | .642 | 379 | 3.51 | 15 | 4 | 0 | 2360.0 | 2,179 | 920 | 995 | 232 | 764 | 79 | 0 | 8 | 9,806 | 58 | 8.34 | 2.91 | 2.86 | 0.88 | 22.3 | 7.8 | 1.25 | .298 | 3.79 | 8.31 |
| 24 | | K. Brown | 2,186 | 425 | 184 | 123 | .599 | 415 | 3.23 | 58 | 15 | 0 | 2846.1 | 2,688 | 1,023 | 1,169 | 182 | 758 | 130 | 1 | 37 | 11,811 | 90 | 6.91 | 2.40 | 2.88 | 0.58 | 18.5 | 6.4 | 1.21 | .293 | 3.70 | 8.50 |
| 25 | | T. Wakefield | 2,156 | 627 | 200 | 180 | .526 | 463 | 4.41 | 33 | 6 | 22 | 3226.1 | 3,152 | 1,582 | 1,791 | 418 | 1,205 | 186 | 78 | 33 | 13,939 | 134 | 6.01 | 3.36 | 1.79 | 1.17 | 15.5 | 8.6 | 1.35 | .274 | 5.00 | 8.79 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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