Between April 18, 1993 and June 13, 2022, Randy Johnson struck out the most hitters, with 4,028 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | R. Johnson | 4,028 | 485 | 253 | 117 | .684 | 471 | 3.12 | 84 | 32 | 2 | 3296.0 | 2,675 | 1,144 | 1,282 | 338 | 965 | 150 | 6 | 31 | 13,393 | 70 | 11.00 | 2.64 | 4.17 | 0.92 | 30.1 | 7.2 | 1.10 | .295 | 3.50 | 7.30 |
| 2 |  | P. Martinez | 3,142 | 472 | 219 | 98 | .691 | 408 | 2.92 | 46 | 17 | 3 | 2814.2 | 2,209 | 912 | 999 | 238 | 755 | 141 | 22 | 30 | 11,341 | 62 | 10.05 | 2.41 | 4.16 | 0.76 | 27.7 | 6.7 | 1.05 | .279 | 3.19 | 7.06 |
| 3 |  | CC Sabathia | 3,093 | 561 | 251 | 161 | .609 | 560 | 3.74 | 38 | 12 | 0 | 3577.1 | 3,404 | 1,485 | 1,623 | 382 | 1,099 | 123 | 0 | 44 | 14,989 | 74 | 7.78 | 2.76 | 2.81 | 0.96 | 20.6 | 7.3 | 1.26 | .294 | 4.08 | 8.56 |
| 4 |  | J. Verlander | 3,091 | 466 | 234 | 131 | .641 | 466 | 3.29 | 26 | 9 | 0 | 3066.2 | 2,587 | 1,122 | 1,213 | 320 | 866 | 101 | 0 | 27 | 12,511 | 87 | 9.07 | 2.54 | 3.57 | 0.94 | 24.7 | 6.9 | 1.13 | .279 | 3.56 | 7.59 |
| 5 |  | M. Scherzer | 3,079 | 415 | 195 | 98 | .666 | 406 | 3.15 | 12 | 5 | 0 | 2586.1 | 2,108 | 904 | 974 | 292 | 688 | 100 | 2 | 20 | 10,459 | 73 | 10.71 | 2.39 | 4.48 | 1.02 | 29.4 | 6.6 | 1.08 | .288 | 3.39 | 7.34 |
| 6 |  | C. Schilling | 2,844 | 424 | 196 | 123 | .614 | 402 | 3.51 | 72 | 15 | 9 | 2867.1 | 2,666 | 1,118 | 1,169 | 326 | 576 | 49 | 21 | 30 | 11,659 | 60 | 8.93 | 1.81 | 4.94 | 1.02 | 24.4 | 4.9 | 1.13 | .298 | 3.67 | 8.37 |
| 7 |  | Z. Greinke | 2,834 | 540 | 219 | 136 | .617 | 498 | 3.44 | 17 | 5 | 1 | 3161.2 | 2,952 | 1,208 | 1,294 | 335 | 722 | 74 | 8 | 25 | 12,922 | 94 | 8.07 | 2.06 | 3.93 | 0.95 | 21.9 | 5.6 | 1.16 | .292 | 3.68 | 8.40 |
| 8 |  | R. Clemens | 2,781 | 433 | 200 | 112 | .641 | 432 | 3.37 | 29 | 12 | 0 | 2861.2 | 2,461 | 1,072 | 1,173 | 234 | 1,024 | 105 | 0 | 27 | 11,915 | 95 | 8.75 | 3.22 | 2.72 | 0.74 | 23.3 | 8.6 | 1.22 | .287 | 3.69 | 7.74 |
| 9 |  | C. Kershaw | 2,706 | 385 | 189 | 85 | .690 | 382 | 2.48 | 25 | 15 | 0 | 2488.2 | 1,881 | 687 | 749 | 199 | 611 | 38 | 1 | 27 | 9,794 | 95 | 9.79 | 2.21 | 4.43 | 0.72 | 27.6 | 6.2 | 1.00 | .270 | 2.71 | 6.80 |
| 10 | | M. Mussina | 2,618 | 491 | 248 | 142 | .636 | 490 | 3.79 | 47 | 19 | 0 | 3219.0 | 3,159 | 1,356 | 1,451 | 349 | 714 | 57 | 0 | 27 | 13,230 | 62 | 7.32 | 2.00 | 3.67 | 0.98 | 19.8 | 5.4 | 1.20 | .296 | 4.06 | 8.83 |
| 11 | | C. Hamels | 2,560 | 423 | 163 | 122 | .572 | 422 | 3.43 | 17 | 7 | 0 | 2698.0 | 2,424 | 1,027 | 1,103 | 310 | 767 | 100 | 0 | 43 | 11,115 | 57 | 8.54 | 2.56 | 3.34 | 1.03 | 23.0 | 6.9 | 1.18 | .287 | 3.68 | 8.09 |
| 12 | | J. Vazquez | 2,536 | 450 | 165 | 160 | .508 | 443 | 4.22 | 28 | 8 | 0 | 2840.0 | 2,784 | 1,331 | 1,431 | 373 | 763 | 88 | 5 | 58 | 11,935 | 76 | 8.04 | 2.42 | 3.32 | 1.18 | 21.2 | 6.4 | 1.25 | .295 | 4.53 | 8.82 |
| 13 |  | B. Colon | 2,535 | 565 | 247 | 188 | .568 | 552 | 4.12 | 38 | 13 | 0 | 3461.2 | 3,593 | 1,584 | 1,719 | 439 | 948 | 64 | 2 | 47 | 14,655 | 45 | 6.59 | 2.46 | 2.67 | 1.14 | 17.3 | 6.5 | 1.31 | .296 | 4.47 | 9.34 |
| 14 |  | F. Hernandez | 2,524 | 419 | 169 | 136 | .554 | 418 | 3.42 | 25 | 11 | 0 | 2729.2 | 2,487 | 1,037 | 1,157 | 264 | 805 | 105 | 0 | 16 | 11,284 | 156 | 8.32 | 2.65 | 3.14 | 0.87 | 22.4 | 7.1 | 1.21 | .293 | 3.81 | 8.20 |
| 15 | | A.J. Burnett | 2,513 | 435 | 164 | 157 | .511 | 430 | 3.99 | 24 | 10 | 0 | 2731.1 | 2,519 | 1,210 | 1,328 | 263 | 1,100 | 143 | 1 | 35 | 11,665 | 161 | 8.28 | 3.62 | 2.28 | 0.87 | 21.5 | 9.4 | 1.32 | .295 | 4.38 | 8.30 |
| 16 |  | J. Lester | 2,488 | 452 | 200 | 117 | .631 | 451 | 3.66 | 15 | 4 | 0 | 2740.0 | 2,610 | 1,114 | 1,215 | 294 | 892 | 90 | 0 | 13 | 11,487 | 63 | 8.17 | 2.93 | 2.79 | 0.97 | 21.7 | 7.8 | 1.28 | .300 | 3.99 | 8.57 |
| 17 | | A. Pettitte | 2,448 | 531 | 256 | 153 | .626 | 521 | 3.85 | 26 | 4 | 0 | 3316.0 | 3,448 | 1,418 | 1,572 | 288 | 1,031 | 55 | 3 | 42 | 14,074 | 69 | 6.64 | 2.80 | 2.37 | 0.78 | 17.4 | 7.3 | 1.35 | .308 | 4.27 | 9.36 |
| 18 |  | G. Maddux | 2,422 | 529 | 259 | 151 | .632 | 529 | 3.08 | 67 | 22 | 0 | 3545.0 | 3,355 | 1,215 | 1,360 | 270 | 539 | 93 | 0 | 107 | 14,298 | 42 | 6.15 | 1.37 | 4.49 | 0.69 | 16.9 | 3.8 | 1.10 | .281 | 3.45 | 8.52 |
| 19 |  | J. Smoltz | 2,325 | 574 | 155 | 99 | .610 | 332 | 3.28 | 26 | 11 | 154 | 2469.1 | 2,208 | 901 | 970 | 210 | 650 | 43 | 204 | 68 | 10,100 | 84 | 8.47 | 2.37 | 3.58 | 0.77 | 23.0 | 6.4 | 1.16 | .291 | 3.54 | 8.05 |
| 20 | | J. Lackey | 2,294 | 448 | 188 | 147 | .561 | 446 | 3.92 | 18 | 8 | 0 | 2840.1 | 2,862 | 1,237 | 1,347 | 319 | 815 | 133 | 0 | 32 | 12,030 | 125 | 7.27 | 2.58 | 2.81 | 1.01 | 19.1 | 6.8 | 1.29 | .300 | 4.27 | 9.07 |
| 21 | | J. Shields | 2,234 | 407 | 145 | 139 | .511 | 405 | 4.01 | 23 | 9 | 0 | 2616.0 | 2,581 | 1,167 | 1,267 | 361 | 746 | 97 | 1 | 22 | 10,993 | 107 | 7.69 | 2.57 | 2.99 | 1.24 | 20.3 | 6.8 | 1.27 | .294 | 4.36 | 8.88 |
| 22 | | J. Peavy | 2,207 | 388 | 152 | 126 | .547 | 377 | 3.63 | 15 | 6 | 0 | 2377.0 | 2,134 | 960 | 1,011 | 259 | 708 | 78 | 3 | 42 | 9,838 | 46 | 8.36 | 2.68 | 3.12 | 0.98 | 22.4 | 7.2 | 1.20 | .285 | 3.83 | 8.08 |
| 23 | | R. Halladay | 2,117 | 416 | 203 | 105 | .659 | 390 | 3.38 | 67 | 20 | 1 | 2749.1 | 2,646 | 1,034 | 1,135 | 236 | 592 | 81 | 6 | 28 | 11,287 | 56 | 6.93 | 1.94 | 3.58 | 0.77 | 18.8 | 5.2 | 1.18 | .292 | 3.72 | 8.66 |
| 24 | | T. Wakefield | 2,092 | 611 | 191 | 177 | .519 | 447 | 4.47 | 29 | 5 | 22 | 3114.1 | 3,054 | 1,547 | 1,751 | 413 | 1,154 | 184 | 78 | 32 | 13,470 | 130 | 6.05 | 3.33 | 1.81 | 1.19 | 15.5 | 8.6 | 1.35 | .274 | 5.06 | 8.83 |
| 25 | | K. Millwood | 2,083 | 451 | 169 | 152 | .526 | 443 | 4.11 | 22 | 6 | 0 | 2720.1 | 2,770 | 1,243 | 1,357 | 296 | 843 | 74 | 3 | 46 | 11,616 | 67 | 6.89 | 2.79 | 2.47 | 0.98 | 17.9 | 7.3 | 1.33 | .297 | 4.49 | 9.16 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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