Between April 26, 1994 and June 17, 2023, Randy Johnson struck out the most hitters, with 3,718 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | R. Johnson | 3,718 | 448 | 233 | 109 | .681 | 435 | 3.10 | 72 | 29 | 1 | 3026.2 | 2,486 | 1,044 | 1,176 | 314 | 859 | 134 | 5 | 31 | 12,300 | 61 | 11.06 | 2.55 | 4.33 | 0.93 | 30.2 | 7.0 | 1.11 | .299 | 3.50 | 7.39 |
| 2 |  | M. Scherzer | 3,253 | 441 | 206 | 104 | .665 | 432 | 3.14 | 12 | 5 | 0 | 2738.2 | 2,236 | 955 | 1,027 | 310 | 715 | 110 | 2 | 20 | 11,068 | 75 | 10.69 | 2.35 | 4.55 | 1.02 | 29.4 | 6.5 | 1.08 | .288 | 3.38 | 7.35 |
| 3 |  | J. Verlander | 3,237 | 490 | 246 | 136 | .644 | 490 | 3.26 | 26 | 9 | 0 | 3208.0 | 2,696 | 1,161 | 1,258 | 329 | 893 | 104 | 0 | 27 | 13,066 | 91 | 9.08 | 2.51 | 3.62 | 0.92 | 24.8 | 6.8 | 1.12 | .278 | 3.53 | 7.56 |
| 4 |  | CC Sabathia | 3,093 | 561 | 251 | 161 | .609 | 560 | 3.74 | 38 | 12 | 0 | 3577.1 | 3,404 | 1,485 | 1,623 | 382 | 1,099 | 123 | 0 | 44 | 14,989 | 74 | 7.78 | 2.76 | 2.81 | 0.96 | 20.6 | 7.3 | 1.26 | .294 | 4.08 | 8.56 |
| 5 |  | P. Martinez | 2,992 | 405 | 209 | 92 | .694 | 402 | 2.94 | 46 | 17 | 1 | 2684.2 | 2,123 | 878 | 962 | 232 | 697 | 132 | 2 | 25 | 10,813 | 57 | 10.03 | 2.34 | 4.29 | 0.78 | 27.7 | 6.4 | 1.05 | .280 | 3.22 | 7.12 |
| 6 |  | Z. Greinke | 2,936 | 570 | 224 | 147 | .604 | 528 | 3.45 | 17 | 5 | 1 | 3318.2 | 3,121 | 1,272 | 1,367 | 354 | 748 | 76 | 8 | 25 | 13,576 | 100 | 7.96 | 2.03 | 3.93 | 0.96 | 21.6 | 5.5 | 1.17 | .292 | 3.71 | 8.46 |
| 7 |  | C. Kershaw | 2,905 | 415 | 205 | 91 | .693 | 412 | 2.49 | 25 | 15 | 0 | 2663.1 | 2,025 | 738 | 807 | 218 | 650 | 41 | 1 | 27 | 10,494 | 98 | 9.82 | 2.20 | 4.47 | 0.74 | 27.7 | 6.2 | 1.00 | .271 | 2.73 | 6.84 |
| 8 |  | C. Schilling | 2,649 | 388 | 182 | 114 | .615 | 366 | 3.45 | 66 | 14 | 9 | 2623.0 | 2,413 | 1,005 | 1,047 | 301 | 514 | 43 | 21 | 23 | 10,625 | 51 | 9.09 | 1.76 | 5.15 | 1.03 | 24.9 | 4.8 | 1.12 | .297 | 3.59 | 8.28 |
| 9 |  | R. Clemens | 2,609 | 402 | 189 | 97 | .661 | 401 | 3.27 | 26 | 10 | 0 | 2659.1 | 2,279 | 967 | 1,062 | 215 | 951 | 95 | 0 | 22 | 11,062 | 92 | 8.83 | 3.22 | 2.74 | 0.73 | 23.6 | 8.6 | 1.21 | .287 | 3.59 | 7.71 |
| 10 | | C. Hamels | 2,560 | 423 | 163 | 122 | .572 | 422 | 3.43 | 17 | 7 | 0 | 2698.0 | 2,424 | 1,027 | 1,103 | 310 | 767 | 100 | 0 | 43 | 11,115 | 57 | 8.54 | 2.56 | 3.34 | 1.03 | 23.0 | 6.9 | 1.18 | .287 | 3.68 | 8.09 |
| 11 | | J. Vazquez | 2,536 | 450 | 165 | 160 | .508 | 443 | 4.22 | 28 | 8 | 0 | 2840.0 | 2,784 | 1,331 | 1,431 | 373 | 763 | 88 | 5 | 58 | 11,935 | 76 | 8.04 | 2.42 | 3.32 | 1.18 | 21.2 | 6.4 | 1.25 | .295 | 4.53 | 8.82 |
| 12 |  | B. Colon | 2,535 | 565 | 247 | 188 | .568 | 552 | 4.12 | 38 | 13 | 0 | 3461.2 | 3,593 | 1,584 | 1,719 | 439 | 948 | 64 | 2 | 47 | 14,655 | 45 | 6.59 | 2.46 | 2.67 | 1.14 | 17.3 | 6.5 | 1.31 | .296 | 4.47 | 9.34 |
| 13 |  | F. Hernandez | 2,524 | 419 | 169 | 136 | .554 | 418 | 3.42 | 25 | 11 | 0 | 2729.2 | 2,487 | 1,037 | 1,157 | 264 | 805 | 105 | 0 | 16 | 11,284 | 156 | 8.32 | 2.65 | 3.14 | 0.87 | 22.4 | 7.1 | 1.21 | .293 | 3.81 | 8.20 |
| 14 | | A.J. Burnett | 2,513 | 435 | 164 | 157 | .511 | 430 | 3.99 | 24 | 10 | 0 | 2731.1 | 2,519 | 1,210 | 1,328 | 263 | 1,100 | 143 | 1 | 35 | 11,665 | 161 | 8.28 | 3.62 | 2.28 | 0.87 | 21.5 | 9.4 | 1.32 | .295 | 4.38 | 8.30 |
| 15 | | M. Mussina | 2,489 | 463 | 230 | 136 | .628 | 462 | 3.76 | 44 | 17 | 0 | 3029.2 | 2,980 | 1,266 | 1,361 | 329 | 663 | 54 | 0 | 24 | 12,448 | 57 | 7.39 | 1.97 | 3.75 | 0.98 | 20.0 | 5.3 | 1.20 | .297 | 4.04 | 8.85 |
| 16 |  | J. Lester | 2,488 | 452 | 200 | 117 | .631 | 451 | 3.66 | 15 | 4 | 0 | 2740.0 | 2,610 | 1,114 | 1,215 | 294 | 892 | 90 | 0 | 13 | 11,487 | 63 | 8.17 | 2.93 | 2.79 | 0.97 | 21.7 | 7.8 | 1.28 | .300 | 3.99 | 8.57 |
| 17 | | A. Pettitte | 2,448 | 531 | 256 | 153 | .626 | 521 | 3.85 | 26 | 4 | 0 | 3316.0 | 3,448 | 1,418 | 1,572 | 288 | 1,031 | 55 | 3 | 42 | 14,074 | 69 | 6.64 | 2.80 | 2.37 | 0.78 | 17.4 | 7.3 | 1.35 | .308 | 4.27 | 9.36 |
| 18 | | J. Lackey | 2,294 | 448 | 188 | 147 | .561 | 446 | 3.92 | 18 | 8 | 0 | 2840.1 | 2,862 | 1,237 | 1,347 | 319 | 815 | 133 | 0 | 32 | 12,030 | 125 | 7.27 | 2.58 | 2.81 | 1.01 | 19.1 | 6.8 | 1.29 | .300 | 4.27 | 9.07 |
| 19 | | J. Shields | 2,234 | 407 | 145 | 139 | .511 | 405 | 4.01 | 23 | 9 | 0 | 2616.0 | 2,581 | 1,167 | 1,267 | 361 | 746 | 97 | 1 | 22 | 10,993 | 107 | 7.69 | 2.57 | 2.99 | 1.24 | 20.3 | 6.8 | 1.27 | .294 | 4.36 | 8.88 |
| 20 | | J. Peavy | 2,207 | 388 | 152 | 126 | .547 | 377 | 3.63 | 15 | 6 | 0 | 2377.0 | 2,134 | 960 | 1,011 | 259 | 708 | 78 | 3 | 42 | 9,838 | 46 | 8.36 | 2.68 | 3.12 | 0.98 | 22.4 | 7.2 | 1.20 | .285 | 3.83 | 8.08 |
| 21 |  | G. Maddux | 2,205 | 491 | 236 | 141 | .626 | 491 | 3.17 | 57 | 20 | 0 | 3258.1 | 3,121 | 1,146 | 1,274 | 256 | 488 | 87 | 0 | 100 | 13,172 | 34 | 6.09 | 1.35 | 4.52 | 0.71 | 16.7 | 3.7 | 1.11 | .283 | 3.52 | 8.62 |
| 22 | | A. Wainwright | 2,171 | 465 | 198 | 118 | .627 | 398 | 3.42 | 28 | 11 | 3 | 2611.0 | 2,486 | 991 | 1,058 | 219 | 708 | 80 | 13 | 40 | 10,833 | 50 | 7.48 | 2.44 | 3.07 | 0.75 | 20.0 | 6.5 | 1.22 | .296 | 3.65 | 8.57 |
| 23 |  | C. Sale | 2,135 | 334 | 119 | 77 | .607 | 254 | 3.08 | 16 | 3 | 12 | 1737.0 | 1,417 | 595 | 643 | 186 | 402 | 109 | 25 | 15 | 7,001 | 40 | 11.06 | 2.08 | 5.31 | 0.96 | 30.5 | 5.7 | 1.05 | .295 | 3.33 | 7.34 |
| 24 | | R. Halladay | 2,117 | 416 | 203 | 105 | .659 | 390 | 3.38 | 67 | 20 | 1 | 2749.1 | 2,646 | 1,034 | 1,135 | 236 | 592 | 81 | 6 | 28 | 11,287 | 56 | 6.93 | 1.94 | 3.58 | 0.77 | 18.8 | 5.2 | 1.18 | .292 | 3.72 | 8.66 |
| 25 |  | J. Smoltz | 2,109 | 538 | 139 | 88 | .612 | 296 | 3.21 | 25 | 10 | 154 | 2220.2 | 1,989 | 793 | 856 | 184 | 550 | 38 | 204 | 57 | 9,049 | 71 | 8.55 | 2.23 | 3.83 | 0.75 | 23.3 | 6.1 | 1.14 | .293 | 3.47 | 8.06 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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