Between July 25, 1991 and September 9, 2020, Randy Johnson struck out the most batters, with 4,385 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | R. Johnson | 4,385 | 532 | 271 | 135 | .667 | 518 | 3.20 | 91 | 35 | 2 | 3604.2 | 2,914 | 1,280 | 1,437 | 360 | 1,171 | 176 | 6 | 33 | 14,749 | 89 | 10.95 | 2.92 | 3.74 | 0.90 | 29.7 | 7.9 | 1.13 | .295 | 3.59 | 7.28 |
| 2 |  | P. Martinez | 3,154 | 476 | 219 | 100 | .687 | 409 | 2.93 | 46 | 17 | 3 | 2827.1 | 2,221 | 919 | 1,006 | 239 | 760 | 141 | 23 | 30 | 11,394 | 62 | 10.04 | 2.42 | 4.15 | 0.76 | 27.7 | 6.7 | 1.05 | .279 | 3.20 | 7.07 |
| 3 |  | R. Clemens | 3,112 | 483 | 227 | 126 | .643 | 482 | 3.27 | 48 | 20 | 0 | 3248.2 | 2,779 | 1,181 | 1,300 | 254 | 1,118 | 118 | 0 | 39 | 13,461 | 101 | 8.62 | 3.10 | 2.78 | 0.70 | 23.1 | 8.3 | 1.20 | .285 | 3.60 | 7.70 |
| 4 |  | CC Sabathia | 3,093 | 561 | 251 | 161 | .609 | 560 | 3.74 | 38 | 12 | 0 | 3577.1 | 3,404 | 1,485 | 1,623 | 382 | 1,099 | 123 | 0 | 44 | 14,989 | 74 | 7.78 | 2.76 | 2.81 | 0.96 | 20.6 | 7.3 | 1.26 | .294 | 4.08 | 8.56 |
| 5 |  | C. Schilling | 3,038 | 497 | 212 | 135 | .611 | 431 | 3.42 | 83 | 20 | 14 | 3158.1 | 2,887 | 1,200 | 1,261 | 340 | 663 | 51 | 47 | 37 | 12,826 | 66 | 8.66 | 1.89 | 4.58 | 0.97 | 23.7 | 5.2 | 1.12 | .292 | 3.59 | 8.23 |
| 6 |  | J. Verlander | 3,013 | 454 | 226 | 129 | .637 | 454 | 3.33 | 26 | 9 | 0 | 2988.0 | 2,538 | 1,105 | 1,192 | 310 | 851 | 98 | 0 | 27 | 12,214 | 87 | 9.08 | 2.56 | 3.54 | 0.93 | 24.7 | 7.0 | 1.13 | .281 | 3.59 | 7.64 |
| 7 | | M. Mussina | 2,813 | 537 | 270 | 153 | .638 | 536 | 3.68 | 57 | 23 | 0 | 3562.2 | 3,460 | 1,458 | 1,559 | 376 | 785 | 60 | 0 | 29 | 14,593 | 71 | 7.11 | 1.98 | 3.58 | 0.95 | 19.3 | 5.4 | 1.19 | .292 | 3.94 | 8.74 |
| 8 |  | M. Scherzer | 2,761 | 374 | 174 | 91 | .657 | 365 | 3.20 | 11 | 5 | 0 | 2340.1 | 1,933 | 832 | 895 | 260 | 635 | 86 | 2 | 19 | 9,494 | 68 | 10.62 | 2.44 | 4.35 | 1.00 | 29.1 | 6.7 | 1.10 | .291 | 3.44 | 7.43 |
| 9 |  | G. Maddux | 2,718 | 583 | 287 | 168 | .631 | 583 | 3.02 | 81 | 27 | 0 | 3951.1 | 3,677 | 1,324 | 1,479 | 283 | 643 | 108 | 0 | 116 | 15,918 | 48 | 6.19 | 1.46 | 4.23 | 0.64 | 17.1 | 4.0 | 1.09 | .279 | 3.37 | 8.38 |
| 10 |  | Z. Greinke | 2,672 | 497 | 208 | 124 | .627 | 456 | 3.35 | 16 | 5 | 1 | 2924.1 | 2,706 | 1,089 | 1,170 | 295 | 675 | 70 | 8 | 25 | 11,937 | 89 | 8.22 | 2.08 | 3.96 | 0.91 | 22.4 | 5.7 | 1.16 | .293 | 3.60 | 8.33 |
| 11 |  | J. Smoltz | 2,631 | 627 | 180 | 115 | .610 | 385 | 3.20 | 41 | 14 | 154 | 2844.2 | 2,505 | 1,010 | 1,091 | 231 | 767 | 50 | 204 | 74 | 11,622 | 109 | 8.32 | 2.43 | 3.43 | 0.73 | 22.6 | 6.6 | 1.15 | .286 | 3.45 | 7.93 |
| 12 | | C. Hamels | 2,558 | 422 | 163 | 121 | .574 | 421 | 3.42 | 17 | 7 | 0 | 2694.2 | 2,421 | 1,024 | 1,100 | 310 | 766 | 100 | 0 | 43 | 11,101 | 57 | 8.54 | 2.56 | 3.34 | 1.04 | 23.0 | 6.9 | 1.18 | .287 | 3.67 | 8.09 |
| 13 | | J. Vazquez | 2,536 | 450 | 165 | 160 | .508 | 443 | 4.22 | 28 | 8 | 0 | 2840.0 | 2,784 | 1,331 | 1,431 | 373 | 763 | 88 | 5 | 58 | 11,935 | 76 | 8.04 | 2.42 | 3.32 | 1.18 | 21.2 | 6.4 | 1.25 | .295 | 4.53 | 8.82 |
| 14 |  | B. Colon | 2,535 | 565 | 247 | 188 | .568 | 552 | 4.12 | 38 | 13 | 0 | 3461.2 | 3,593 | 1,584 | 1,719 | 439 | 948 | 64 | 2 | 47 | 14,655 | 45 | 6.59 | 2.46 | 2.67 | 1.14 | 17.3 | 6.5 | 1.31 | .296 | 4.47 | 9.34 |
| 15 |  | F. Hernandez | 2,524 | 419 | 169 | 136 | .554 | 418 | 3.42 | 25 | 11 | 0 | 2729.2 | 2,487 | 1,037 | 1,157 | 264 | 805 | 105 | 0 | 16 | 11,284 | 156 | 8.32 | 2.65 | 3.14 | 0.87 | 22.4 | 7.1 | 1.21 | .293 | 3.81 | 8.20 |
| 16 | | A.J. Burnett | 2,513 | 435 | 164 | 157 | .511 | 430 | 3.99 | 24 | 10 | 0 | 2731.1 | 2,519 | 1,210 | 1,328 | 263 | 1,100 | 143 | 1 | 35 | 11,665 | 161 | 8.28 | 3.62 | 2.28 | 0.87 | 21.5 | 9.4 | 1.32 | .295 | 4.38 | 8.30 |
| 17 |  | C. Kershaw | 2,508 | 354 | 174 | 75 | .699 | 351 | 2.43 | 25 | 15 | 0 | 2315.2 | 1,739 | 626 | 682 | 178 | 585 | 34 | 1 | 27 | 9,114 | 88 | 9.75 | 2.27 | 4.29 | 0.69 | 27.5 | 6.4 | 1.00 | .269 | 2.65 | 6.76 |
| 18 | | A. Pettitte | 2,448 | 531 | 256 | 153 | .626 | 521 | 3.85 | 26 | 4 | 0 | 3316.0 | 3,448 | 1,418 | 1,572 | 288 | 1,031 | 55 | 3 | 42 | 14,074 | 69 | 6.64 | 2.80 | 2.37 | 0.78 | 17.4 | 7.3 | 1.35 | .308 | 4.27 | 9.36 |
| 19 |  | J. Lester | 2,384 | 420 | 192 | 110 | .636 | 419 | 3.60 | 15 | 4 | 0 | 2578.0 | 2,434 | 1,031 | 1,122 | 267 | 830 | 87 | 0 | 8 | 10,777 | 62 | 8.32 | 2.90 | 2.87 | 0.93 | 22.1 | 7.7 | 1.27 | .301 | 3.92 | 8.50 |
| 20 | | J. Lackey | 2,294 | 448 | 188 | 147 | .561 | 446 | 3.92 | 18 | 8 | 0 | 2840.1 | 2,862 | 1,237 | 1,347 | 319 | 815 | 133 | 0 | 32 | 12,030 | 125 | 7.27 | 2.58 | 2.81 | 1.01 | 19.1 | 6.8 | 1.29 | .300 | 4.27 | 9.07 |
| 21 | | J. Shields | 2,234 | 407 | 145 | 139 | .511 | 405 | 4.01 | 23 | 9 | 0 | 2616.0 | 2,581 | 1,167 | 1,267 | 361 | 746 | 97 | 1 | 22 | 10,993 | 107 | 7.69 | 2.57 | 2.99 | 1.24 | 20.3 | 6.8 | 1.27 | .294 | 4.36 | 8.88 |
| 22 | | J. Peavy | 2,207 | 388 | 152 | 126 | .547 | 377 | 3.63 | 15 | 6 | 0 | 2377.0 | 2,134 | 960 | 1,011 | 259 | 708 | 78 | 3 | 42 | 9,838 | 46 | 8.36 | 2.68 | 3.12 | 0.98 | 22.4 | 7.2 | 1.20 | .285 | 3.83 | 8.08 |
| 23 | | T. Glavine | 2,160 | 557 | 259 | 157 | .623 | 557 | 3.46 | 41 | 20 | 0 | 3619.1 | 3,520 | 1,390 | 1,516 | 292 | 1,260 | 50 | 0 | 120 | 15,248 | 45 | 5.37 | 3.13 | 1.71 | 0.73 | 14.2 | 8.3 | 1.32 | .281 | 3.77 | 8.75 |
| 24 | | T. Wakefield | 2,156 | 627 | 200 | 180 | .526 | 463 | 4.41 | 33 | 6 | 22 | 3226.1 | 3,152 | 1,582 | 1,791 | 418 | 1,205 | 186 | 78 | 33 | 13,939 | 134 | 6.01 | 3.36 | 1.79 | 1.17 | 15.5 | 8.6 | 1.35 | .274 | 5.00 | 8.79 |
| 25 | | K. Brown | 2,139 | 408 | 178 | 116 | .605 | 398 | 3.19 | 58 | 15 | 0 | 2737.2 | 2,569 | 969 | 1,112 | 175 | 712 | 123 | 1 | 33 | 11,335 | 84 | 7.03 | 2.34 | 3.00 | 0.58 | 18.9 | 6.3 | 1.20 | .292 | 3.66 | 8.45 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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