Between July 28, 1987 and May 17, 2017, Randy Johnson fanned the most hitters, with 4,875 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | R. Johnson | 4,875 | 618 | 303 | 166 | .646 | 603 | 3.29 | 100 | 37 | 2 | 4135.1 | 3,346 | 1,513 | 1,703 | 411 | 1,497 | 190 | 7 | 37 | 17,067 | 109 | 10.61 | 3.26 | 3.26 | 0.89 | 28.6 | 8.8 | 1.17 | .291 | 3.71 | 7.28 |
| 2 |  | R. Clemens | 4,094 | 618 | 304 | 164 | .650 | 617 | 3.11 | 89 | 39 | 0 | 4260.0 | 3,627 | 1,473 | 1,634 | 311 | 1,391 | 142 | 0 | 56 | 17,552 | 123 | 8.65 | 2.94 | 2.94 | 0.66 | 23.3 | 7.9 | 1.18 | .286 | 3.45 | 7.66 |
| 3 |  | G. Maddux | 3,275 | 717 | 347 | 215 | .617 | 715 | 3.11 | 107 | 34 | 0 | 4856.1 | 4,554 | 1,676 | 1,892 | 336 | 941 | 132 | 2 | 169 | 19,758 | 65 | 6.07 | 1.74 | 3.48 | 0.62 | 16.6 | 4.8 | 1.13 | .280 | 3.51 | 8.44 |
| 4 |  | P. Martinez | 3,154 | 476 | 219 | 100 | .687 | 409 | 2.93 | 46 | 17 | 3 | 2827.1 | 2,221 | 919 | 1,006 | 239 | 760 | 141 | 23 | 30 | 11,394 | 62 | 10.04 | 2.42 | 4.15 | 0.76 | 27.7 | 6.7 | 1.05 | .279 | 3.20 | 7.07 |
| 5 |  | C. Schilling | 3,116 | 569 | 216 | 146 | .597 | 436 | 3.46 | 83 | 20 | 22 | 3261.0 | 2,998 | 1,253 | 1,318 | 347 | 711 | 52 | 81 | 43 | 13,284 | 72 | 8.60 | 1.96 | 4.38 | 0.96 | 23.5 | 5.4 | 1.14 | .293 | 3.64 | 8.27 |
| 6 |  | J. Smoltz | 3,084 | 723 | 213 | 155 | .579 | 481 | 3.33 | 53 | 16 | 154 | 3473.0 | 3,074 | 1,284 | 1,391 | 288 | 1,010 | 57 | 204 | 84 | 14,271 | 145 | 7.99 | 2.62 | 3.05 | 0.75 | 21.6 | 7.1 | 1.18 | .283 | 3.60 | 7.97 |
| 7 | | M. Mussina | 2,813 | 537 | 270 | 153 | .638 | 536 | 3.68 | 57 | 23 | 0 | 3562.2 | 3,460 | 1,458 | 1,559 | 376 | 785 | 60 | 0 | 29 | 14,593 | 71 | 7.11 | 1.98 | 3.58 | 0.95 | 19.3 | 5.4 | 1.19 | .292 | 3.94 | 8.74 |
| 8 |  | CC Sabathia | 2,757 | 490 | 226 | 143 | .612 | 490 | 3.72 | 38 | 12 | 0 | 3214.0 | 3,050 | 1,328 | 1,449 | 321 | 978 | 107 | 0 | 43 | 13,435 | 67 | 7.72 | 2.74 | 2.82 | 0.90 | 20.5 | 7.3 | 1.25 | .294 | 4.06 | 8.54 |
| 9 | | D. Cone | 2,617 | 429 | 192 | 124 | .608 | 413 | 3.43 | 55 | 22 | 1 | 2829.0 | 2,428 | 1,078 | 1,180 | 250 | 1,097 | 105 | 3 | 40 | 11,868 | 144 | 8.33 | 3.49 | 2.39 | 0.80 | 22.1 | 9.2 | 1.25 | .279 | 3.75 | 7.72 |
| 10 | | T. Glavine | 2,607 | 682 | 305 | 203 | .600 | 682 | 3.54 | 56 | 25 | 0 | 4413.1 | 4,298 | 1,734 | 1,900 | 356 | 1,500 | 66 | 0 | 145 | 18,604 | 65 | 5.32 | 3.06 | 1.74 | 0.73 | 14.0 | 8.1 | 1.31 | .280 | 3.87 | 8.76 |
| 11 | | J. Vazquez | 2,536 | 450 | 165 | 160 | .508 | 443 | 4.22 | 28 | 8 | 0 | 2840.0 | 2,784 | 1,331 | 1,431 | 373 | 763 | 88 | 5 | 58 | 11,935 | 76 | 8.04 | 2.42 | 3.32 | 1.18 | 21.2 | 6.4 | 1.25 | .295 | 4.53 | 8.82 |
| 12 | | C. Finley | 2,521 | 475 | 195 | 168 | .537 | 467 | 3.83 | 63 | 15 | 0 | 3092.2 | 2,962 | 1,317 | 1,464 | 298 | 1,281 | 75 | 4 | 33 | 13,180 | 124 | 7.34 | 3.73 | 1.97 | 0.87 | 19.1 | 9.7 | 1.37 | .296 | 4.26 | 8.62 |
| 13 | | A.J. Burnett | 2,513 | 435 | 164 | 157 | .511 | 430 | 3.99 | 24 | 10 | 0 | 2731.1 | 2,519 | 1,210 | 1,328 | 263 | 1,100 | 143 | 1 | 35 | 11,665 | 161 | 8.28 | 3.62 | 2.28 | 0.87 | 21.5 | 9.4 | 1.32 | .295 | 4.38 | 8.30 |
| 14 | | A. Pettitte | 2,448 | 531 | 256 | 153 | .626 | 521 | 3.85 | 26 | 4 | 0 | 3316.0 | 3,448 | 1,418 | 1,572 | 288 | 1,031 | 55 | 3 | 42 | 14,074 | 69 | 6.64 | 2.80 | 2.37 | 0.78 | 17.4 | 7.3 | 1.35 | .308 | 4.27 | 9.36 |
| 15 | | K. Brown | 2,393 | 485 | 210 | 144 | .593 | 475 | 3.27 | 72 | 17 | 0 | 3251.1 | 3,073 | 1,183 | 1,355 | 208 | 901 | 139 | 1 | 42 | 13,523 | 108 | 6.62 | 2.49 | 2.66 | 0.58 | 17.7 | 6.7 | 1.22 | .290 | 3.75 | 8.51 |
| 16 |  | B. Colon | 2,392 | 517 | 235 | 166 | .586 | 508 | 3.97 | 36 | 13 | 0 | 3216.0 | 3,282 | 1,420 | 1,544 | 387 | 899 | 61 | 1 | 46 | 13,569 | 42 | 6.69 | 2.52 | 2.66 | 1.08 | 17.6 | 6.6 | 1.30 | .295 | 4.32 | 9.18 |
| 17 | | J. Moyer | 2,301 | 658 | 253 | 198 | .561 | 602 | 4.23 | 31 | 9 | 0 | 3856.2 | 4,003 | 1,813 | 1,956 | 499 | 1,049 | 139 | 14 | 63 | 16,394 | 45 | 5.37 | 2.45 | 2.19 | 1.16 | 14.0 | 6.4 | 1.31 | .282 | 4.56 | 9.34 |
| 18 |  | F. Hernandez | 2,286 | 364 | 156 | 111 | .584 | 364 | 3.18 | 25 | 11 | 0 | 2442.1 | 2,196 | 862 | 960 | 209 | 698 | 83 | 0 | 16 | 10,024 | 135 | 8.42 | 2.57 | 3.28 | 0.77 | 22.8 | 7.0 | 1.18 | .294 | 3.54 | 8.09 |
| 19 |  | J. Verlander | 2,246 | 360 | 176 | 109 | .618 | 360 | 3.49 | 23 | 7 | 0 | 2387.1 | 2,116 | 926 | 1,007 | 222 | 724 | 81 | 0 | 23 | 9,876 | 75 | 8.47 | 2.73 | 3.10 | 0.84 | 22.7 | 7.3 | 1.19 | .287 | 3.80 | 7.98 |
| 20 | | J. Peavy | 2,207 | 388 | 152 | 126 | .547 | 377 | 3.63 | 15 | 6 | 0 | 2377.0 | 2,134 | 960 | 1,011 | 259 | 708 | 78 | 3 | 42 | 9,838 | 46 | 8.36 | 2.68 | 3.12 | 0.98 | 22.4 | 7.2 | 1.20 | .285 | 3.83 | 8.08 |
| 21 | | D. Wells | 2,195 | 658 | 239 | 155 | .607 | 487 | 4.11 | 54 | 12 | 13 | 3433.2 | 3,620 | 1,569 | 1,693 | 407 | 715 | 83 | 65 | 65 | 14,379 | 98 | 5.75 | 1.87 | 3.07 | 1.07 | 15.3 | 5.0 | 1.26 | .293 | 4.44 | 9.49 |
| 22 | | J. Lackey | 2,194 | 425 | 180 | 138 | .566 | 424 | 3.89 | 18 | 8 | 0 | 2717.0 | 2,748 | 1,173 | 1,280 | 293 | 775 | 122 | 0 | 29 | 11,506 | 116 | 7.27 | 2.57 | 2.83 | 0.97 | 19.1 | 6.7 | 1.30 | .302 | 4.24 | 9.10 |
| 23 | | T. Wakefield | 2,156 | 627 | 200 | 180 | .526 | 463 | 4.41 | 33 | 6 | 22 | 3226.1 | 3,152 | 1,582 | 1,791 | 418 | 1,205 | 186 | 78 | 33 | 13,939 | 134 | 6.01 | 3.36 | 1.79 | 1.17 | 15.5 | 8.6 | 1.35 | .274 | 5.00 | 8.79 |
| 24 | | C. Hamels | 2,137 | 344 | 138 | 96 | .590 | 343 | 3.31 | 15 | 7 | 0 | 2247.0 | 2,004 | 826 | 882 | 250 | 604 | 67 | 0 | 41 | 9,195 | 44 | 8.56 | 2.42 | 3.54 | 1.00 | 23.2 | 6.6 | 1.16 | .286 | 3.53 | 8.03 |
| 25 | | R. Halladay | 2,117 | 416 | 203 | 105 | .659 | 390 | 3.38 | 67 | 20 | 1 | 2749.1 | 2,646 | 1,034 | 1,135 | 236 | 592 | 81 | 6 | 28 | 11,287 | 56 | 6.93 | 1.94 | 3.58 | 0.77 | 18.8 | 5.2 | 1.18 | .292 | 3.72 | 8.66 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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