Between May 19, 1969 and September 22, 1993, Nolan Ryan struck out the most hitters, with 5,555 strikeouts.
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | N. Ryan | 5,555 | 777 | 316 | 282 | .528 | 753 | 3.19 | 219 | 61 | 2 | 5228.1 | 3,810 | 1,855 | 2,117 | 307 | 2,705 | 154 | 9 | 73 | 21,911 | 269 | 9.56 | 4.66 | 2.05 | 0.53 | 25.4 | 12.3 | 1.25 | .266 | 3.64 | 6.56 |
| 2 |  | S. Carlton | 3,722 | 646 | 296 | 217 | .577 | 630 | 3.25 | 229 | 47 | 1 | 4665.1 | 4,160 | 1,687 | 1,928 | 387 | 1,655 | 47 | 6 | 142 | 19,382 | 163 | 7.18 | 3.19 | 2.25 | 0.75 | 19.2 | 8.5 | 1.25 | .278 | 3.72 | 8.03 |
| 3 |  | B. Blyleven | 3,701 | 692 | 287 | 250 | .534 | 685 | 3.31 | 242 | 60 | 0 | 4970.0 | 4,632 | 1,830 | 2,029 | 430 | 1,322 | 155 | 3 | 71 | 20,492 | 114 | 6.70 | 2.39 | 2.80 | 0.78 | 18.1 | 6.5 | 1.20 | .282 | 3.67 | 8.39 |
| 4 |  | T. Seaver | 3,223 | 576 | 274 | 178 | .606 | 570 | 2.92 | 195 | 54 | 0 | 4189.2 | 3,469 | 1,360 | 1,498 | 340 | 1,242 | 62 | 3 | 102 | 16,983 | 108 | 6.92 | 2.67 | 2.60 | 0.73 | 19.0 | 7.3 | 1.12 | .258 | 3.22 | 7.45 |
| 5 | | D. Sutton | 2,986 | 656 | 286 | 211 | .575 | 651 | 3.27 | 151 | 49 | 3 | 4551.1 | 4,051 | 1,656 | 1,831 | 427 | 1,154 | 70 | 4 | 73 | 18,644 | 98 | 5.90 | 2.28 | 2.59 | 0.84 | 16.0 | 6.2 | 1.14 | .259 | 3.62 | 8.01 |
| 6 | | P. Niekro | 2,952 | 693 | 281 | 245 | .534 | 654 | 3.47 | 214 | 37 | 9 | 4737.1 | 4,474 | 1,828 | 2,100 | 444 | 1,640 | 102 | 25 | 71 | 19,968 | 175 | 5.61 | 3.12 | 1.80 | 0.84 | 14.8 | 8.2 | 1.29 | .272 | 3.99 | 8.50 |
| 7 | | F. Tanana | 2,764 | 636 | 240 | 235 | .505 | 614 | 3.66 | 143 | 34 | 1 | 4175.2 | 4,053 | 1,698 | 1,904 | 447 | 1,251 | 129 | 10 | 116 | 17,587 | 119 | 5.96 | 2.70 | 2.21 | 0.96 | 15.7 | 7.1 | 1.27 | .277 | 4.10 | 8.74 |
| 8 | | G. Perry | 2,473 | 518 | 232 | 192 | .547 | 515 | 3.13 | 234 | 41 | 1 | 3911.2 | 3,642 | 1,362 | 1,580 | 298 | 1,019 | 79 | 3 | 96 | 16,043 | 110 | 5.69 | 2.34 | 2.43 | 0.69 | 15.4 | 6.4 | 1.19 | .275 | 3.64 | 8.38 |
| 9 | | F. Jenkins | 2,471 | 508 | 231 | 187 | .553 | 494 | 3.46 | 219 | 39 | 1 | 3628.1 | 3,435 | 1,394 | 1,552 | 394 | 779 | 74 | 9 | 88 | 14,906 | 53 | 6.13 | 1.93 | 3.17 | 0.98 | 16.6 | 5.2 | 1.16 | .272 | 3.85 | 8.52 |
| 10 |  | J. Morris | 2,378 | 526 | 244 | 180 | .575 | 504 | 3.83 | 174 | 28 | 0 | 3682.2 | 3,404 | 1,569 | 1,719 | 375 | 1,323 | 54 | 10 | 97 | 15,484 | 192 | 5.81 | 3.23 | 1.80 | 0.92 | 15.4 | 8.5 | 1.28 | .267 | 4.20 | 8.32 |
| 11 | | J. Koosman | 2,354 | 564 | 202 | 193 | .511 | 486 | 3.44 | 122 | 25 | 17 | 3530.2 | 3,368 | 1,348 | 1,510 | 270 | 1,104 | 63 | 42 | 109 | 14,733 | 79 | 6.00 | 2.81 | 2.13 | 0.69 | 16.0 | 7.5 | 1.27 | .283 | 3.85 | 8.59 |
| 12 | | C. Hough | 2,285 | 835 | 211 | 207 | .505 | 417 | 3.71 | 106 | 12 | 61 | 3674.1 | 3,157 | 1,515 | 1,729 | 366 | 1,604 | 163 | 240 | 43 | 15,593 | 169 | 5.60 | 3.93 | 1.42 | 0.90 | 14.7 | 10.3 | 1.30 | .250 | 4.24 | 7.73 |
| 13 | | D. Eckersley | 2,196 | 801 | 183 | 149 | .551 | 361 | 3.45 | 100 | 20 | 272 | 3035.2 | 2,813 | 1,164 | 1,255 | 313 | 692 | 65 | 374 | 83 | 12,480 | 26 | 6.51 | 2.05 | 3.17 | 0.93 | 17.6 | 5.5 | 1.15 | .271 | 3.72 | 8.34 |
| 14 | | V. Blue | 2,175 | 502 | 209 | 161 | .565 | 473 | 3.27 | 143 | 37 | 2 | 3343.1 | 2,939 | 1,213 | 1,357 | 263 | 1,185 | 23 | 11 | 61 | 13,838 | 103 | 5.85 | 3.19 | 1.84 | 0.71 | 15.7 | 8.6 | 1.23 | .263 | 3.65 | 7.91 |
| 15 |  | R. Clemens | 2,033 | 302 | 163 | 86 | .655 | 301 | 2.94 | 91 | 35 | 0 | 2222.2 | 1,878 | 726 | 807 | 145 | 619 | 64 | 0 | 40 | 9,037 | 51 | 8.23 | 2.51 | 3.28 | 0.59 | 22.5 | 6.8 | 1.12 | .281 | 3.27 | 7.60 |
| 16 | | R. Reuschel | 2,015 | 557 | 214 | 191 | .528 | 529 | 3.37 | 102 | 26 | 5 | 3548.1 | 3,588 | 1,330 | 1,494 | 221 | 935 | 88 | 16 | 117 | 14,888 | 89 | 5.11 | 2.37 | 2.16 | 0.56 | 13.5 | 6.3 | 1.27 | .290 | 3.79 | 9.10 |
| 17 | | M. Langston | 1,984 | 331 | 143 | 124 | .536 | 328 | 3.69 | 74 | 16 | 0 | 2307.1 | 2,015 | 945 | 1,054 | 224 | 1,022 | 40 | 1 | 24 | 9,698 | 65 | 7.74 | 3.99 | 1.94 | 0.87 | 20.5 | 10.5 | 1.32 | .279 | 4.11 | 7.86 |
| 18 | | B. Welch | 1,924 | 480 | 208 | 139 | .599 | 453 | 3.37 | 61 | 28 | 8 | 3019.1 | 2,808 | 1,132 | 1,249 | 254 | 989 | 78 | 16 | 57 | 12,611 | 51 | 5.74 | 2.95 | 1.95 | 0.76 | 15.3 | 7.8 | 1.26 | .273 | 3.72 | 8.37 |
| 19 | | J. Palmer | 1,921 | 484 | 240 | 135 | .640 | 468 | 2.82 | 199 | 49 | 3 | 3532.0 | 3,025 | 1,105 | 1,231 | 267 | 1,121 | 35 | 8 | 35 | 14,405 | 73 | 4.89 | 2.86 | 1.71 | 0.68 | 13.3 | 7.8 | 1.17 | .249 | 3.14 | 7.71 |
| 20 | | J. Reuss | 1,907 | 628 | 220 | 191 | .535 | 547 | 3.64 | 127 | 39 | 11 | 3669.2 | 3,734 | 1,483 | 1,701 | 245 | 1,127 | 59 | 41 | 118 | 15,581 | 109 | 4.68 | 2.76 | 1.69 | 0.60 | 12.2 | 7.2 | 1.32 | .285 | 4.17 | 9.16 |
| 21 | | F. Valenzuela | 1,840 | 363 | 148 | 128 | .536 | 351 | 3.44 | 112 | 31 | 2 | 2525.2 | 2,278 | 966 | 1,089 | 173 | 991 | 20 | 5 | 60 | 10,617 | 102 | 6.56 | 3.53 | 1.86 | 0.62 | 17.3 | 9.3 | 1.29 | .277 | 3.88 | 8.12 |
| 22 | | D. Gooden | 1,835 | 298 | 154 | 81 | .655 | 296 | 3.04 | 67 | 23 | 1 | 2128.1 | 1,852 | 718 | 791 | 114 | 636 | 40 | 1 | 30 | 8,716 | 45 | 7.76 | 2.69 | 2.89 | 0.48 | 21.1 | 7.3 | 1.17 | .285 | 3.34 | 7.83 |
| 23 | | D. Martinez | 1,821 | 556 | 207 | 164 | .558 | 474 | 3.64 | 110 | 23 | 6 | 3369.1 | 3,251 | 1,364 | 1,520 | 313 | 987 | 90 | 40 | 58 | 14,076 | 75 | 4.86 | 2.64 | 1.84 | 0.84 | 12.9 | 7.0 | 1.26 | .270 | 4.06 | 8.68 |
| 24 | | F. Viola | 1,813 | 406 | 174 | 145 | .545 | 405 | 3.66 | 74 | 16 | 0 | 2760.2 | 2,730 | 1,123 | 1,247 | 283 | 823 | 46 | 0 | 35 | 11,583 | 82 | 5.91 | 2.68 | 2.20 | 0.92 | 15.7 | 7.1 | 1.29 | .284 | 4.07 | 8.90 |
| 25 | | R. Guidry | 1,778 | 368 | 170 | 91 | .651 | 323 | 3.29 | 95 | 26 | 4 | 2392.0 | 2,198 | 874 | 953 | 226 | 633 | 13 | 23 | 24 | 9,794 | 56 | 6.69 | 2.38 | 2.81 | 0.85 | 18.2 | 6.5 | 1.18 | .276 | 3.59 | 8.27 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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| NL East | W | L | PCT | GB |
|---|---|---|---|---|
 Braves - y | 94 | 68 | .580 | |
 Phillies - w | 88 | 74 | .543 | 6.0 |
80 | 82 | .494 | 14.0 | |
77 | 85 | .475 | 17.0 | |
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| NL Central | W | L | PCT | GB |
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 Cubs - w | 89 | 73 | .549 | 14.0 |
82 | 80 | .506 | 21.0 | |
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| NL West | W | L | PCT | GB |
 Dodgers - y | 100 | 62 | .617 | |
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|---|---|---|---|---|
 Rays - y | 98 | 64 | .605 | |
 Yankees - w | 93 | 68 | .578 | 4.5 |
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| AL Central | W | L | PCT | GB |
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| AL West | W | L | PCT | GB |
 Astros - y | 81 | 81 | .500 | |
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