Between September 14, 1972 and August 11, 1994, Nolan Ryan fanned the most batters, with 4,946 strikeouts.
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | N. Ryan | 4,946 | 668 | 279 | 240 | .538 | 665 | 3.19 | 193 | 50 | 1 | 4636.0 | 3,409 | 1,641 | 1,877 | 274 | 2,316 | 124 | 3 | 61 | 19,370 | 239 | 9.60 | 4.50 | 2.14 | 0.53 | 25.5 | 12.0 | 1.23 | .268 | 3.64 | 6.62 |
| 2 |  | B. Blyleven | 3,153 | 593 | 248 | 210 | .541 | 589 | 3.37 | 212 | 52 | 0 | 4282.0 | 4,004 | 1,603 | 1,781 | 372 | 1,152 | 140 | 1 | 57 | 17,686 | 100 | 6.63 | 2.42 | 2.74 | 0.78 | 17.8 | 6.5 | 1.20 | .282 | 3.74 | 8.42 |
| 3 |  | S. Carlton | 2,908 | 515 | 229 | 173 | .570 | 501 | 3.34 | 163 | 31 | 1 | 3650.0 | 3,284 | 1,356 | 1,558 | 310 | 1,303 | 35 | 6 | 103 | 15,197 | 125 | 7.17 | 3.21 | 2.23 | 0.76 | 19.1 | 8.6 | 1.26 | .279 | 3.84 | 8.10 |
| 4 | | F. Tanana | 2,773 | 638 | 240 | 236 | .504 | 616 | 3.66 | 143 | 34 | 1 | 4188.1 | 4,063 | 1,702 | 1,910 | 448 | 1,255 | 129 | 10 | 116 | 17,641 | 119 | 5.96 | 2.70 | 2.21 | 0.96 | 15.7 | 7.1 | 1.27 | .277 | 4.10 | 8.73 |
| 5 |  | J. Morris | 2,478 | 549 | 254 | 186 | .577 | 527 | 3.90 | 175 | 28 | 0 | 3824.0 | 3,567 | 1,657 | 1,815 | 389 | 1,390 | 58 | 10 | 99 | 16,120 | 205 | 5.83 | 3.27 | 1.78 | 0.92 | 15.4 | 8.6 | 1.30 | .269 | 4.27 | 8.40 |
| 6 | | C. Hough | 2,350 | 846 | 216 | 216 | .500 | 440 | 3.74 | 107 | 13 | 59 | 3780.0 | 3,262 | 1,570 | 1,793 | 375 | 1,650 | 174 | 232 | 44 | 16,070 | 180 | 5.60 | 3.93 | 1.42 | 0.89 | 14.6 | 10.3 | 1.30 | .251 | 4.27 | 7.77 |
| 7 | | P. Niekro | 2,317 | 552 | 224 | 191 | .540 | 526 | 3.52 | 157 | 28 | 7 | 3766.1 | 3,582 | 1,475 | 1,687 | 339 | 1,416 | 88 | 17 | 54 | 15,973 | 139 | 5.54 | 3.38 | 1.64 | 0.81 | 14.5 | 8.9 | 1.33 | .275 | 4.03 | 8.56 |
| 8 |  | T. Seaver | 2,279 | 446 | 199 | 140 | .587 | 442 | 3.08 | 131 | 41 | 0 | 3179.1 | 2,691 | 1,089 | 1,197 | 265 | 972 | 44 | 1 | 86 | 12,976 | 90 | 6.45 | 2.75 | 2.34 | 0.75 | 17.6 | 7.5 | 1.15 | .258 | 3.39 | 7.62 |
| 9 | | D. Sutton | 2,249 | 519 | 226 | 162 | .582 | 515 | 3.31 | 107 | 33 | 2 | 3562.2 | 3,181 | 1,311 | 1,444 | 344 | 902 | 49 | 3 | 54 | 14,598 | 70 | 5.68 | 2.28 | 2.49 | 0.87 | 15.4 | 6.2 | 1.15 | .257 | 3.65 | 8.04 |
| 10 | | D. Eckersley | 2,245 | 849 | 188 | 153 | .551 | 361 | 3.46 | 100 | 20 | 294 | 3082.2 | 2,863 | 1,186 | 1,282 | 319 | 705 | 66 | 416 | 85 | 12,682 | 26 | 6.55 | 2.06 | 3.18 | 0.93 | 17.7 | 5.6 | 1.16 | .272 | 3.74 | 8.36 |
| 11 |  | R. Clemens | 2,201 | 326 | 172 | 93 | .649 | 325 | 2.93 | 94 | 36 | 0 | 2393.1 | 2,002 | 780 | 869 | 160 | 690 | 68 | 0 | 41 | 9,729 | 55 | 8.28 | 2.59 | 3.19 | 0.60 | 22.6 | 7.1 | 1.12 | .279 | 3.27 | 7.53 |
| 12 | | M. Langston | 2,110 | 352 | 151 | 134 | .530 | 349 | 3.74 | 77 | 17 | 0 | 2448.1 | 2,158 | 1,017 | 1,132 | 244 | 1,081 | 40 | 1 | 25 | 10,305 | 74 | 7.76 | 3.97 | 1.95 | 0.90 | 20.5 | 10.5 | 1.32 | .280 | 4.16 | 7.93 |
| 13 | | B. Welch | 1,969 | 506 | 211 | 146 | .591 | 462 | 3.47 | 61 | 28 | 8 | 3092.0 | 2,894 | 1,191 | 1,310 | 267 | 1,034 | 79 | 20 | 60 | 12,956 | 55 | 5.73 | 3.01 | 1.90 | 0.78 | 15.2 | 8.0 | 1.27 | .273 | 3.81 | 8.42 |
| 14 | | R. Reuschel | 1,944 | 540 | 206 | 184 | .528 | 514 | 3.38 | 98 | 23 | 5 | 3442.1 | 3,485 | 1,294 | 1,454 | 218 | 910 | 86 | 15 | 111 | 14,454 | 88 | 5.08 | 2.38 | 2.14 | 0.57 | 13.4 | 6.3 | 1.28 | .289 | 3.80 | 9.11 |
| 15 | | D. Martinez | 1,923 | 582 | 219 | 171 | .562 | 500 | 3.63 | 117 | 26 | 6 | 3560.2 | 3,427 | 1,436 | 1,602 | 327 | 1,034 | 98 | 40 | 60 | 14,865 | 79 | 4.86 | 2.61 | 1.86 | 0.83 | 12.9 | 7.0 | 1.25 | .270 | 4.05 | 8.66 |
| 16 | | D. Gooden | 1,875 | 305 | 157 | 85 | .649 | 303 | 3.10 | 67 | 23 | 1 | 2169.2 | 1,898 | 747 | 823 | 123 | 651 | 41 | 1 | 31 | 8,898 | 47 | 7.78 | 2.70 | 2.88 | 0.51 | 21.1 | 7.3 | 1.17 | .286 | 3.41 | 7.87 |
| 17 | | F. Valenzuela | 1,861 | 373 | 150 | 130 | .536 | 360 | 3.44 | 112 | 31 | 2 | 2579.0 | 2,334 | 986 | 1,111 | 181 | 1,004 | 20 | 5 | 61 | 10,843 | 104 | 6.49 | 3.50 | 1.85 | 0.63 | 17.2 | 9.3 | 1.29 | .277 | 3.88 | 8.15 |
| 18 | | J. Koosman | 1,845 | 449 | 159 | 157 | .503 | 384 | 3.54 | 95 | 18 | 16 | 2794.1 | 2,722 | 1,100 | 1,228 | 212 | 873 | 51 | 37 | 74 | 11,699 | 53 | 5.94 | 2.81 | 2.11 | 0.68 | 15.8 | 7.5 | 1.29 | .288 | 3.96 | 8.77 |
| 19 | | F. Viola | 1,822 | 412 | 175 | 146 | .545 | 411 | 3.67 | 74 | 16 | 0 | 2791.2 | 2,764 | 1,139 | 1,264 | 285 | 840 | 46 | 0 | 35 | 11,719 | 84 | 5.87 | 2.71 | 2.17 | 0.92 | 15.5 | 7.2 | 1.29 | .284 | 4.07 | 8.91 |
| 20 | | R. Guidry | 1,778 | 368 | 170 | 91 | .651 | 323 | 3.29 | 95 | 26 | 4 | 2392.0 | 2,198 | 874 | 953 | 226 | 633 | 13 | 23 | 24 | 9,794 | 56 | 6.69 | 2.38 | 2.81 | 0.85 | 18.2 | 6.5 | 1.18 | .276 | 3.59 | 8.27 |
| 21 | | F. Bannister | 1,723 | 431 | 134 | 143 | .484 | 363 | 4.06 | 62 | 16 | 0 | 2388.0 | 2,320 | 1,078 | 1,189 | 291 | 846 | 40 | 13 | 39 | 10,187 | 84 | 6.49 | 3.19 | 2.04 | 1.10 | 16.9 | 8.3 | 1.33 | .278 | 4.48 | 8.74 |
| 22 | | V. Blue | 1,721 | 424 | 177 | 144 | .551 | 404 | 3.41 | 113 | 24 | 1 | 2822.2 | 2,556 | 1,068 | 1,193 | 222 | 1,029 | 18 | 10 | 54 | 11,778 | 91 | 5.49 | 3.28 | 1.67 | 0.71 | 14.6 | 8.7 | 1.27 | .266 | 3.80 | 8.15 |
| 23 | | G. Perry | 1,719 | 373 | 160 | 140 | .533 | 371 | 3.34 | 153 | 28 | 0 | 2751.0 | 2,650 | 1,021 | 1,161 | 218 | 724 | 47 | 2 | 60 | 11,339 | 69 | 5.62 | 2.37 | 2.37 | 0.71 | 15.2 | 6.4 | 1.23 | .282 | 3.80 | 8.67 |
| 24 | | B. Hurst | 1,689 | 379 | 145 | 113 | .562 | 359 | 3.92 | 83 | 23 | 0 | 2417.1 | 2,463 | 1,052 | 1,143 | 258 | 740 | 28 | 5 | 42 | 10,204 | 56 | 6.29 | 2.76 | 2.28 | 0.96 | 16.6 | 7.3 | 1.33 | .294 | 4.26 | 9.17 |
| 25 | | D. Stewart | 1,683 | 507 | 165 | 122 | .575 | 332 | 3.86 | 55 | 9 | 19 | 2548.2 | 2,398 | 1,092 | 1,194 | 253 | 995 | 60 | 87 | 45 | 10,870 | 111 | 5.94 | 3.51 | 1.69 | 0.89 | 15.5 | 9.2 | 1.33 | .272 | 4.22 | 8.47 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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