Between September 19, 1993 and August 31, 2022, Randy Johnson struck out the most batters, with 3,780 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | R. Johnson | 3,780 | 456 | 237 | 110 | .683 | 443 | 3.10 | 76 | 30 | 1 | 3090.0 | 2,528 | 1,066 | 1,199 | 321 | 883 | 137 | 5 | 31 | 12,549 | 63 | 11.01 | 2.57 | 4.28 | 0.93 | 30.1 | 7.0 | 1.10 | .297 | 3.49 | 7.36 |
| 2 |  | M. Scherzer | 3,168 | 426 | 199 | 101 | .663 | 417 | 3.12 | 12 | 5 | 0 | 2659.1 | 2,164 | 921 | 992 | 296 | 699 | 107 | 2 | 20 | 10,749 | 73 | 10.72 | 2.37 | 4.53 | 1.00 | 29.5 | 6.5 | 1.08 | .288 | 3.36 | 7.32 |
| 3 |  | J. Verlander | 3,167 | 478 | 242 | 132 | .647 | 478 | 3.26 | 26 | 9 | 0 | 3140.0 | 2,642 | 1,136 | 1,231 | 322 | 877 | 102 | 0 | 27 | 12,796 | 89 | 9.08 | 2.51 | 3.61 | 0.92 | 24.7 | 6.9 | 1.12 | .279 | 3.53 | 7.57 |
| 4 |  | CC Sabathia | 3,093 | 561 | 251 | 161 | .609 | 560 | 3.74 | 38 | 12 | 0 | 3577.1 | 3,404 | 1,485 | 1,623 | 382 | 1,099 | 123 | 0 | 44 | 14,989 | 74 | 7.78 | 2.76 | 2.81 | 0.96 | 20.6 | 7.3 | 1.26 | .294 | 4.08 | 8.56 |
| 5 |  | P. Martinez | 3,038 | 413 | 209 | 96 | .685 | 408 | 2.95 | 46 | 17 | 1 | 2722.2 | 2,151 | 892 | 978 | 234 | 707 | 137 | 3 | 26 | 10,965 | 61 | 10.04 | 2.34 | 4.30 | 0.77 | 27.7 | 6.4 | 1.05 | .280 | 3.23 | 7.11 |
| 6 |  | Z. Greinke | 2,873 | 551 | 223 | 140 | .614 | 509 | 3.44 | 17 | 5 | 1 | 3218.2 | 3,018 | 1,229 | 1,318 | 342 | 733 | 75 | 8 | 25 | 13,167 | 96 | 8.03 | 2.05 | 3.92 | 0.96 | 21.8 | 5.6 | 1.17 | .293 | 3.69 | 8.44 |
| 7 |  | C. Kershaw | 2,758 | 394 | 192 | 87 | .688 | 391 | 2.49 | 25 | 15 | 0 | 2540.0 | 1,928 | 704 | 770 | 203 | 621 | 39 | 1 | 27 | 10,003 | 95 | 9.77 | 2.20 | 4.44 | 0.72 | 27.6 | 6.2 | 1.00 | .270 | 2.73 | 6.83 |
| 8 |  | C. Schilling | 2,693 | 396 | 184 | 118 | .609 | 374 | 3.46 | 67 | 14 | 9 | 2675.1 | 2,467 | 1,030 | 1,072 | 306 | 532 | 46 | 21 | 26 | 10,851 | 54 | 9.06 | 1.79 | 5.06 | 1.03 | 24.8 | 4.9 | 1.12 | .297 | 3.61 | 8.30 |
| 9 |  | R. Clemens | 2,641 | 408 | 191 | 99 | .659 | 407 | 3.28 | 27 | 11 | 0 | 2700.0 | 2,311 | 984 | 1,081 | 218 | 963 | 96 | 0 | 23 | 11,228 | 92 | 8.80 | 3.21 | 2.74 | 0.73 | 23.5 | 8.6 | 1.21 | .286 | 3.60 | 7.70 |
| 10 | | C. Hamels | 2,560 | 423 | 163 | 122 | .572 | 422 | 3.43 | 17 | 7 | 0 | 2698.0 | 2,424 | 1,027 | 1,103 | 310 | 767 | 100 | 0 | 43 | 11,115 | 57 | 8.54 | 2.56 | 3.34 | 1.03 | 23.0 | 6.9 | 1.18 | .287 | 3.68 | 8.09 |
| 11 | | J. Vazquez | 2,536 | 450 | 165 | 160 | .508 | 443 | 4.22 | 28 | 8 | 0 | 2840.0 | 2,784 | 1,331 | 1,431 | 373 | 763 | 88 | 5 | 58 | 11,935 | 76 | 8.04 | 2.42 | 3.32 | 1.18 | 21.2 | 6.4 | 1.25 | .295 | 4.53 | 8.82 |
| 12 |  | B. Colon | 2,535 | 565 | 247 | 188 | .568 | 552 | 4.12 | 38 | 13 | 0 | 3461.2 | 3,593 | 1,584 | 1,719 | 439 | 948 | 64 | 2 | 47 | 14,655 | 45 | 6.59 | 2.46 | 2.67 | 1.14 | 17.3 | 6.5 | 1.31 | .296 | 4.47 | 9.34 |
| 13 |  | F. Hernandez | 2,524 | 419 | 169 | 136 | .554 | 418 | 3.42 | 25 | 11 | 0 | 2729.2 | 2,487 | 1,037 | 1,157 | 264 | 805 | 105 | 0 | 16 | 11,284 | 156 | 8.32 | 2.65 | 3.14 | 0.87 | 22.4 | 7.1 | 1.21 | .293 | 3.81 | 8.20 |
| 14 | | M. Mussina | 2,514 | 468 | 234 | 137 | .631 | 467 | 3.75 | 44 | 17 | 0 | 3066.1 | 3,008 | 1,279 | 1,374 | 333 | 672 | 54 | 0 | 25 | 12,594 | 57 | 7.38 | 1.97 | 3.74 | 0.98 | 20.0 | 5.3 | 1.20 | .297 | 4.03 | 8.83 |
| 15 | | A.J. Burnett | 2,513 | 435 | 164 | 157 | .511 | 430 | 3.99 | 24 | 10 | 0 | 2731.1 | 2,519 | 1,210 | 1,328 | 263 | 1,100 | 143 | 1 | 35 | 11,665 | 161 | 8.28 | 3.62 | 2.28 | 0.87 | 21.5 | 9.4 | 1.32 | .295 | 4.38 | 8.30 |
| 16 |  | J. Lester | 2,488 | 452 | 200 | 117 | .631 | 451 | 3.66 | 15 | 4 | 0 | 2740.0 | 2,610 | 1,114 | 1,215 | 294 | 892 | 90 | 0 | 13 | 11,487 | 63 | 8.17 | 2.93 | 2.79 | 0.97 | 21.7 | 7.8 | 1.28 | .300 | 3.99 | 8.57 |
| 17 | | A. Pettitte | 2,448 | 531 | 256 | 153 | .626 | 521 | 3.85 | 26 | 4 | 0 | 3316.0 | 3,448 | 1,418 | 1,572 | 288 | 1,031 | 55 | 3 | 42 | 14,074 | 69 | 6.64 | 2.80 | 2.37 | 0.78 | 17.4 | 7.3 | 1.35 | .308 | 4.27 | 9.36 |
| 18 | | J. Lackey | 2,294 | 448 | 188 | 147 | .561 | 446 | 3.92 | 18 | 8 | 0 | 2840.1 | 2,862 | 1,237 | 1,347 | 319 | 815 | 133 | 0 | 32 | 12,030 | 125 | 7.27 | 2.58 | 2.81 | 1.01 | 19.1 | 6.8 | 1.29 | .300 | 4.27 | 9.07 |
| 19 |  | G. Maddux | 2,250 | 499 | 242 | 143 | .629 | 499 | 3.12 | 59 | 21 | 0 | 3321.1 | 3,164 | 1,153 | 1,286 | 258 | 496 | 87 | 0 | 101 | 13,409 | 37 | 6.10 | 1.34 | 4.54 | 0.70 | 16.8 | 3.7 | 1.10 | .282 | 3.48 | 8.57 |
| 20 | | J. Shields | 2,234 | 407 | 145 | 139 | .511 | 405 | 4.01 | 23 | 9 | 0 | 2616.0 | 2,581 | 1,167 | 1,267 | 361 | 746 | 97 | 1 | 22 | 10,993 | 107 | 7.69 | 2.57 | 2.99 | 1.24 | 20.3 | 6.8 | 1.27 | .294 | 4.36 | 8.88 |
| 21 | | J. Peavy | 2,207 | 388 | 152 | 126 | .547 | 377 | 3.63 | 15 | 6 | 0 | 2377.0 | 2,134 | 960 | 1,011 | 259 | 708 | 78 | 3 | 42 | 9,838 | 46 | 8.36 | 2.68 | 3.12 | 0.98 | 22.4 | 7.2 | 1.20 | .285 | 3.83 | 8.08 |
| 22 |  | J. Smoltz | 2,155 | 545 | 142 | 91 | .609 | 303 | 3.26 | 25 | 10 | 154 | 2266.0 | 2,038 | 820 | 884 | 189 | 566 | 38 | 204 | 58 | 9,247 | 74 | 8.56 | 2.25 | 3.81 | 0.75 | 23.3 | 6.1 | 1.15 | .294 | 3.51 | 8.09 |
| 23 | | A. Wainwright | 2,134 | 451 | 193 | 114 | .629 | 384 | 3.34 | 28 | 11 | 3 | 2538.2 | 2,382 | 941 | 1,005 | 211 | 684 | 79 | 13 | 40 | 10,494 | 50 | 7.57 | 2.42 | 3.12 | 0.75 | 20.3 | 6.5 | 1.21 | .294 | 3.56 | 8.44 |
| 24 | | R. Halladay | 2,117 | 416 | 203 | 105 | .659 | 390 | 3.38 | 67 | 20 | 1 | 2749.1 | 2,646 | 1,034 | 1,135 | 236 | 592 | 81 | 6 | 28 | 11,287 | 56 | 6.93 | 1.94 | 3.58 | 0.77 | 18.8 | 5.2 | 1.18 | .292 | 3.72 | 8.66 |
| 25 | | K. Millwood | 2,083 | 451 | 169 | 152 | .526 | 443 | 4.11 | 22 | 6 | 0 | 2720.1 | 2,770 | 1,243 | 1,357 | 296 | 843 | 74 | 3 | 46 | 11,616 | 67 | 6.89 | 2.79 | 2.47 | 0.98 | 17.9 | 7.3 | 1.33 | .297 | 4.49 | 9.16 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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