Between September 4, 1991 and May 22, 2018, Randy Johnson struck out the most batters, with 4,336 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | R. Johnson | 4,336 | 525 | 267 | 132 | .669 | 511 | 3.17 | 90 | 34 | 2 | 3564.1 | 2,874 | 1,256 | 1,410 | 356 | 1,152 | 173 | 6 | 33 | 14,570 | 85 | 10.95 | 2.91 | 3.76 | 0.90 | 29.8 | 7.9 | 1.13 | .294 | 3.56 | 7.26 |
| 2 |  | P. Martinez | 3,154 | 476 | 219 | 100 | .687 | 409 | 2.93 | 46 | 17 | 3 | 2827.1 | 2,221 | 919 | 1,006 | 239 | 760 | 141 | 23 | 30 | 11,394 | 62 | 10.04 | 2.42 | 4.15 | 0.76 | 27.7 | 6.7 | 1.05 | .279 | 3.20 | 7.07 |
| 3 |  | R. Clemens | 3,057 | 475 | 224 | 125 | .642 | 474 | 3.28 | 44 | 19 | 0 | 3189.1 | 2,732 | 1,161 | 1,277 | 250 | 1,098 | 116 | 0 | 36 | 13,222 | 100 | 8.63 | 3.10 | 2.78 | 0.71 | 23.1 | 8.3 | 1.20 | .285 | 3.60 | 7.71 |
| 4 |  | C. Schilling | 3,023 | 483 | 212 | 135 | .611 | 431 | 3.42 | 83 | 20 | 13 | 3136.0 | 2,865 | 1,193 | 1,252 | 339 | 650 | 51 | 39 | 37 | 12,728 | 65 | 8.68 | 1.87 | 4.65 | 0.97 | 23.8 | 5.1 | 1.12 | .292 | 3.59 | 8.22 |
| 5 |  | CC Sabathia | 2,879 | 517 | 239 | 147 | .619 | 517 | 3.68 | 38 | 12 | 0 | 3358.1 | 3,178 | 1,375 | 1,504 | 341 | 1,018 | 111 | 0 | 44 | 14,029 | 72 | 7.72 | 2.73 | 2.83 | 0.91 | 20.5 | 7.3 | 1.25 | .293 | 4.03 | 8.52 |
| 6 | | M. Mussina | 2,785 | 531 | 268 | 149 | .643 | 530 | 3.68 | 57 | 23 | 0 | 3523.2 | 3,419 | 1,439 | 1,539 | 371 | 771 | 59 | 0 | 29 | 14,424 | 69 | 7.11 | 1.97 | 3.61 | 0.95 | 19.3 | 5.3 | 1.19 | .292 | 3.93 | 8.73 |
| 7 |  | G. Maddux | 2,668 | 574 | 284 | 165 | .633 | 574 | 3.00 | 79 | 27 | 0 | 3889.2 | 3,611 | 1,297 | 1,450 | 280 | 622 | 108 | 0 | 114 | 15,655 | 47 | 6.17 | 1.44 | 4.29 | 0.65 | 17.0 | 4.0 | 1.09 | .278 | 3.36 | 8.36 |
| 8 |  | J. Smoltz | 2,589 | 618 | 174 | 113 | .606 | 376 | 3.20 | 38 | 14 | 154 | 2785.0 | 2,460 | 989 | 1,070 | 227 | 749 | 49 | 204 | 74 | 11,386 | 104 | 8.37 | 2.42 | 3.46 | 0.73 | 22.7 | 6.6 | 1.15 | .287 | 3.46 | 7.95 |
| 9 | | J. Vazquez | 2,536 | 450 | 165 | 160 | .508 | 443 | 4.22 | 28 | 8 | 0 | 2840.0 | 2,784 | 1,331 | 1,431 | 373 | 763 | 88 | 5 | 58 | 11,935 | 76 | 8.04 | 2.42 | 3.32 | 1.18 | 21.2 | 6.4 | 1.25 | .295 | 4.53 | 8.82 |
| 10 | | A.J. Burnett | 2,513 | 435 | 164 | 157 | .511 | 430 | 3.99 | 24 | 10 | 0 | 2731.1 | 2,519 | 1,210 | 1,328 | 263 | 1,100 | 143 | 1 | 35 | 11,665 | 161 | 8.28 | 3.62 | 2.28 | 0.87 | 21.5 | 9.4 | 1.32 | .295 | 4.38 | 8.30 |
| 11 |  | J. Verlander | 2,500 | 395 | 193 | 116 | .625 | 395 | 3.40 | 24 | 8 | 0 | 2613.2 | 2,277 | 987 | 1,071 | 248 | 785 | 87 | 0 | 27 | 10,769 | 79 | 8.61 | 2.70 | 3.18 | 0.85 | 23.2 | 7.3 | 1.17 | .284 | 3.69 | 7.84 |
| 12 |  | B. Colon | 2,490 | 547 | 242 | 178 | .576 | 536 | 4.04 | 37 | 13 | 0 | 3371.2 | 3,468 | 1,512 | 1,645 | 420 | 928 | 63 | 2 | 46 | 14,247 | 43 | 6.65 | 2.48 | 2.68 | 1.12 | 17.5 | 6.5 | 1.30 | .295 | 4.39 | 9.26 |
| 13 | | A. Pettitte | 2,448 | 531 | 256 | 153 | .626 | 521 | 3.85 | 26 | 4 | 0 | 3316.0 | 3,448 | 1,418 | 1,572 | 288 | 1,031 | 55 | 3 | 42 | 14,074 | 69 | 6.64 | 2.80 | 2.37 | 0.78 | 17.4 | 7.3 | 1.35 | .308 | 4.27 | 9.36 |
| 14 |  | F. Hernandez | 2,391 | 385 | 165 | 117 | .585 | 385 | 3.25 | 25 | 11 | 0 | 2557.2 | 2,297 | 924 | 1,027 | 230 | 746 | 92 | 0 | 16 | 10,519 | 143 | 8.41 | 2.63 | 3.21 | 0.81 | 22.7 | 7.1 | 1.19 | .293 | 3.61 | 8.08 |
| 15 |  | Z. Greinke | 2,303 | 432 | 175 | 110 | .614 | 391 | 3.41 | 16 | 5 | 1 | 2516.1 | 2,358 | 953 | 1,026 | 253 | 601 | 61 | 8 | 20 | 10,321 | 80 | 8.24 | 2.15 | 3.83 | 0.90 | 22.3 | 5.8 | 1.18 | .296 | 3.67 | 8.43 |
| 16 | | J. Lackey | 2,294 | 448 | 188 | 147 | .561 | 446 | 3.92 | 18 | 8 | 0 | 2840.1 | 2,862 | 1,237 | 1,347 | 319 | 815 | 133 | 0 | 32 | 12,030 | 125 | 7.27 | 2.58 | 2.81 | 1.01 | 19.1 | 6.8 | 1.29 | .300 | 4.27 | 9.07 |
| 17 | | C. Hamels | 2,291 | 373 | 150 | 106 | .586 | 372 | 3.37 | 16 | 7 | 0 | 2421.0 | 2,153 | 906 | 969 | 275 | 668 | 82 | 0 | 42 | 9,933 | 52 | 8.52 | 2.48 | 3.43 | 1.02 | 23.1 | 6.7 | 1.17 | .284 | 3.60 | 8.00 |
| 18 |  | M. Scherzer | 2,253 | 315 | 148 | 76 | .661 | 306 | 3.25 | 9 | 5 | 0 | 1962.2 | 1,629 | 708 | 767 | 218 | 550 | 69 | 2 | 14 | 7,973 | 63 | 10.33 | 2.52 | 4.10 | 1.00 | 28.3 | 6.9 | 1.11 | .289 | 3.52 | 7.47 |
| 19 | | J. Peavy | 2,207 | 388 | 152 | 126 | .547 | 377 | 3.63 | 15 | 6 | 0 | 2377.0 | 2,134 | 960 | 1,011 | 259 | 708 | 78 | 3 | 42 | 9,838 | 46 | 8.36 | 2.68 | 3.12 | 0.98 | 22.4 | 7.2 | 1.20 | .285 | 3.83 | 8.08 |
| 20 |  | C. Kershaw | 2,168 | 299 | 145 | 68 | .681 | 297 | 2.37 | 25 | 15 | 0 | 1979.0 | 1,471 | 522 | 568 | 135 | 517 | 29 | 1 | 27 | 7,783 | 74 | 9.86 | 2.35 | 4.19 | 0.61 | 27.9 | 6.6 | 1.00 | .271 | 2.58 | 6.69 |
| 21 | | T. Wakefield | 2,156 | 627 | 200 | 180 | .526 | 463 | 4.41 | 33 | 6 | 22 | 3226.1 | 3,152 | 1,582 | 1,791 | 418 | 1,205 | 186 | 78 | 33 | 13,939 | 134 | 6.01 | 3.36 | 1.79 | 1.17 | 15.5 | 8.6 | 1.35 | .274 | 5.00 | 8.79 |
| 22 | | J. Shields | 2,121 | 384 | 139 | 127 | .523 | 382 | 3.99 | 23 | 9 | 0 | 2473.2 | 2,443 | 1,096 | 1,184 | 331 | 695 | 90 | 1 | 22 | 10,385 | 99 | 7.72 | 2.53 | 3.05 | 1.20 | 20.4 | 6.7 | 1.27 | .295 | 4.31 | 8.89 |
| 23 | | T. Glavine | 2,119 | 549 | 255 | 153 | .625 | 549 | 3.47 | 39 | 20 | 0 | 3561.2 | 3,478 | 1,375 | 1,494 | 287 | 1,238 | 50 | 0 | 118 | 15,015 | 44 | 5.35 | 3.13 | 1.71 | 0.73 | 14.1 | 8.2 | 1.32 | .282 | 3.78 | 8.79 |
| 24 | | R. Halladay | 2,117 | 416 | 203 | 105 | .659 | 390 | 3.38 | 67 | 20 | 1 | 2749.1 | 2,646 | 1,034 | 1,135 | 236 | 592 | 81 | 6 | 28 | 11,287 | 56 | 6.93 | 1.94 | 3.58 | 0.77 | 18.8 | 5.2 | 1.18 | .292 | 3.72 | 8.66 |
| 25 | | K. Brown | 2,108 | 400 | 176 | 114 | .607 | 390 | 3.18 | 58 | 15 | 0 | 2683.1 | 2,512 | 949 | 1,086 | 169 | 689 | 118 | 1 | 32 | 11,096 | 81 | 7.07 | 2.31 | 3.06 | 0.57 | 19.0 | 6.2 | 1.19 | .292 | 3.64 | 8.43 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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