Between September 27, 1991 and September 29, 2013, Randy Johnson struck out the most batters, with 4,310 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | R. Johnson | 4,310 | 521 | 267 | 132 | .669 | 507 | 3.16 | 90 | 34 | 2 | 3540.1 | 2,858 | 1,245 | 1,399 | 354 | 1,133 | 170 | 6 | 33 | 14,463 | 84 | 10.96 | 2.88 | 3.80 | 0.90 | 29.8 | 7.8 | 1.13 | .295 | 3.56 | 7.27 |
| 2 |  | P. Martinez | 3,154 | 476 | 219 | 100 | .687 | 409 | 2.93 | 46 | 17 | 3 | 2827.1 | 2,221 | 919 | 1,006 | 239 | 760 | 141 | 23 | 30 | 11,394 | 62 | 10.04 | 2.42 | 4.15 | 0.76 | 27.7 | 6.7 | 1.05 | .279 | 3.20 | 7.07 |
| 3 |  | R. Clemens | 3,021 | 470 | 220 | 125 | .638 | 469 | 3.30 | 41 | 17 | 0 | 3146.1 | 2,703 | 1,153 | 1,269 | 249 | 1,094 | 115 | 0 | 35 | 13,063 | 100 | 8.64 | 3.13 | 2.76 | 0.71 | 23.1 | 8.4 | 1.21 | .286 | 3.63 | 7.73 |
| 4 |  | C. Schilling | 3,013 | 473 | 212 | 135 | .611 | 431 | 3.43 | 83 | 20 | 11 | 3122.2 | 2,853 | 1,189 | 1,248 | 339 | 644 | 51 | 33 | 35 | 12,671 | 65 | 8.68 | 1.86 | 4.68 | 0.98 | 23.8 | 5.1 | 1.12 | .292 | 3.60 | 8.22 |
| 5 | | M. Mussina | 2,773 | 527 | 266 | 148 | .643 | 526 | 3.69 | 55 | 23 | 0 | 3492.0 | 3,391 | 1,432 | 1,531 | 370 | 769 | 59 | 0 | 29 | 14,304 | 68 | 7.15 | 1.98 | 3.61 | 0.95 | 19.4 | 5.4 | 1.19 | .292 | 3.95 | 8.74 |
| 6 |  | G. Maddux | 2,650 | 570 | 282 | 164 | .632 | 570 | 3.00 | 78 | 27 | 0 | 3858.1 | 3,589 | 1,288 | 1,440 | 279 | 617 | 107 | 0 | 114 | 15,534 | 47 | 6.18 | 1.44 | 4.29 | 0.65 | 17.1 | 4.0 | 1.09 | .279 | 3.36 | 8.37 |
| 7 |  | J. Smoltz | 2,573 | 614 | 173 | 113 | .605 | 372 | 3.21 | 38 | 14 | 154 | 2757.0 | 2,438 | 983 | 1,064 | 227 | 741 | 49 | 204 | 74 | 11,277 | 104 | 8.40 | 2.42 | 3.47 | 0.74 | 22.8 | 6.6 | 1.15 | .288 | 3.47 | 7.96 |
| 8 | | J. Vazquez | 2,536 | 450 | 165 | 160 | .508 | 443 | 4.22 | 28 | 8 | 0 | 2840.0 | 2,784 | 1,331 | 1,431 | 373 | 763 | 88 | 5 | 58 | 11,935 | 76 | 8.04 | 2.42 | 3.32 | 1.18 | 21.2 | 6.4 | 1.25 | .295 | 4.53 | 8.82 |
| 9 | | A. Pettitte | 2,448 | 531 | 256 | 153 | .626 | 521 | 3.85 | 26 | 4 | 0 | 3316.0 | 3,448 | 1,418 | 1,572 | 288 | 1,031 | 55 | 3 | 42 | 14,074 | 69 | 6.64 | 2.80 | 2.37 | 0.78 | 17.4 | 7.3 | 1.35 | .308 | 4.27 | 9.36 |
| 10 |  | CC Sabathia | 2,389 | 415 | 205 | 115 | .641 | 415 | 3.60 | 37 | 12 | 0 | 2775.1 | 2,585 | 1,110 | 1,217 | 255 | 834 | 85 | 0 | 39 | 11,530 | 57 | 7.75 | 2.70 | 2.86 | 0.83 | 20.7 | 7.2 | 1.23 | .292 | 3.95 | 8.38 |
| 11 | | A.J. Burnett | 2,180 | 375 | 147 | 132 | .527 | 370 | 3.99 | 23 | 10 | 0 | 2353.2 | 2,140 | 1,043 | 1,142 | 232 | 955 | 116 | 1 | 31 | 10,031 | 146 | 8.34 | 3.65 | 2.28 | 0.89 | 21.7 | 9.5 | 1.31 | .291 | 4.37 | 8.18 |
| 12 | | T. Wakefield | 2,156 | 627 | 200 | 180 | .526 | 463 | 4.41 | 33 | 6 | 22 | 3226.1 | 3,152 | 1,582 | 1,791 | 418 | 1,205 | 186 | 78 | 33 | 13,939 | 134 | 6.01 | 3.36 | 1.79 | 1.17 | 15.5 | 8.6 | 1.35 | .274 | 5.00 | 8.79 |
| 13 | | R. Halladay | 2,117 | 416 | 203 | 105 | .659 | 390 | 3.38 | 67 | 20 | 1 | 2749.1 | 2,646 | 1,034 | 1,135 | 236 | 592 | 81 | 6 | 28 | 11,287 | 56 | 6.93 | 1.94 | 3.58 | 0.77 | 18.8 | 5.2 | 1.18 | .292 | 3.72 | 8.66 |
| 14 | | T. Glavine | 2,107 | 545 | 253 | 151 | .626 | 545 | 3.46 | 39 | 20 | 0 | 3534.2 | 3,446 | 1,359 | 1,478 | 284 | 1,225 | 50 | 0 | 115 | 14,895 | 42 | 5.36 | 3.12 | 1.72 | 0.72 | 14.1 | 8.2 | 1.32 | .282 | 3.76 | 8.77 |
| 15 | | K. Brown | 2,094 | 396 | 176 | 113 | .609 | 386 | 3.18 | 58 | 15 | 0 | 2655.1 | 2,480 | 937 | 1,070 | 168 | 677 | 118 | 1 | 32 | 10,972 | 79 | 7.10 | 2.29 | 3.09 | 0.57 | 19.1 | 6.2 | 1.19 | .292 | 3.63 | 8.41 |
| 16 | | K. Millwood | 2,083 | 451 | 169 | 152 | .526 | 443 | 4.11 | 22 | 6 | 0 | 2720.1 | 2,770 | 1,243 | 1,357 | 296 | 843 | 74 | 3 | 46 | 11,616 | 67 | 6.89 | 2.79 | 2.47 | 0.98 | 17.9 | 7.3 | 1.33 | .297 | 4.49 | 9.16 |
| 17 | | R. Dempster | 2,075 | 579 | 132 | 133 | .498 | 351 | 4.35 | 11 | 3 | 87 | 2387.0 | 2,347 | 1,154 | 1,250 | 267 | 1,071 | 91 | 186 | 47 | 10,412 | 80 | 7.82 | 4.04 | 1.94 | 1.01 | 19.9 | 10.3 | 1.43 | .301 | 4.71 | 8.85 |
| 18 | | J. Moyer | 2,006 | 555 | 235 | 155 | .603 | 527 | 4.19 | 26 | 8 | 0 | 3374.0 | 3,465 | 1,571 | 1,682 | 443 | 873 | 127 | 6 | 48 | 14,281 | 35 | 5.35 | 2.33 | 2.30 | 1.18 | 14.0 | 6.1 | 1.29 | .279 | 4.49 | 9.24 |
| 19 | | J. Santana | 1,988 | 360 | 139 | 78 | .641 | 284 | 3.20 | 15 | 10 | 1 | 2025.2 | 1,726 | 721 | 773 | 220 | 567 | 36 | 23 | 13 | 8,262 | 68 | 8.83 | 2.52 | 3.51 | 0.98 | 24.1 | 6.9 | 1.13 | .276 | 3.43 | 7.67 |
| 20 | | L. Hernandez | 1,976 | 519 | 178 | 177 | .501 | 474 | 4.44 | 50 | 9 | 1 | 3189.0 | 3,525 | 1,572 | 1,686 | 362 | 1,066 | 78 | 17 | 86 | 13,816 | 41 | 5.58 | 3.01 | 1.85 | 1.02 | 14.3 | 7.7 | 1.44 | .306 | 4.76 | 9.95 |
| 21 |  | B. Colon | 1,950 | 411 | 189 | 128 | .596 | 405 | 3.94 | 35 | 12 | 0 | 2583.2 | 2,594 | 1,132 | 1,238 | 308 | 802 | 48 | 0 | 36 | 10,927 | 40 | 6.79 | 2.79 | 2.43 | 1.07 | 17.8 | 7.3 | 1.31 | .292 | 4.31 | 9.04 |
| 22 | | H. Nomo | 1,918 | 323 | 123 | 109 | .530 | 318 | 4.24 | 16 | 9 | 0 | 1976.1 | 1,768 | 932 | 993 | 251 | 908 | 38 | 2 | 31 | 8,462 | 110 | 8.73 | 4.13 | 2.11 | 1.14 | 22.7 | 10.7 | 1.35 | .284 | 4.52 | 8.05 |
| 23 | | C. Finley | 1,907 | 340 | 135 | 123 | .523 | 340 | 4.05 | 41 | 10 | 0 | 2217.2 | 2,162 | 998 | 1,111 | 228 | 925 | 54 | 0 | 21 | 9,520 | 100 | 7.74 | 3.75 | 2.06 | 0.93 | 20.0 | 9.7 | 1.39 | .302 | 4.51 | 8.77 |
| 24 | | T. Hudson | 1,896 | 427 | 205 | 111 | .649 | 426 | 3.44 | 25 | 13 | 0 | 2813.2 | 2,624 | 1,077 | 1,171 | 220 | 846 | 110 | 0 | 80 | 11,691 | 78 | 6.06 | 2.71 | 2.24 | 0.70 | 16.2 | 7.2 | 1.23 | .279 | 3.75 | 8.39 |
| 25 | | B. Zito | 1,883 | 430 | 165 | 143 | .536 | 419 | 4.02 | 12 | 5 | 0 | 2569.2 | 2,369 | 1,149 | 1,246 | 278 | 1,058 | 97 | 8 | 52 | 10,964 | 50 | 6.60 | 3.71 | 1.78 | 0.97 | 17.2 | 9.6 | 1.33 | .273 | 4.36 | 8.30 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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