Between August 19, 1995 and September 20, 2016, Randy Johnson fanned the most batters, with 3,333 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | R. Johnson | 3,333 | 408 | 210 | 102 | .673 | 395 | 3.13 | 61 | 23 | 1 | 2737.1 | 2,257 | 951 | 1,074 | 296 | 764 | 125 | 5 | 28 | 11,128 | 54 | 10.96 | 2.51 | 4.36 | 0.97 | 30.0 | 6.9 | 1.10 | .297 | 3.53 | 7.42 |
| 2 |  | P. Martinez | 2,762 | 363 | 187 | 82 | .695 | 361 | 2.88 | 44 | 15 | 0 | 2425.2 | 1,909 | 777 | 857 | 207 | 606 | 119 | 1 | 22 | 9,763 | 49 | 10.25 | 2.25 | 4.56 | 0.77 | 28.3 | 6.2 | 1.04 | .280 | 3.18 | 7.08 |
| 3 |  | CC Sabathia | 2,716 | 480 | 222 | 141 | .612 | 480 | 3.72 | 38 | 12 | 0 | 3154.0 | 2,995 | 1,302 | 1,422 | 314 | 954 | 104 | 0 | 43 | 13,181 | 66 | 7.75 | 2.72 | 2.85 | 0.90 | 20.6 | 7.2 | 1.25 | .295 | 4.06 | 8.55 |
| 4 |  | J. Vazquez | 2,536 | 450 | 165 | 160 | .508 | 443 | 4.22 | 28 | 8 | 0 | 2840.0 | 2,784 | 1,331 | 1,431 | 373 | 763 | 88 | 5 | 58 | 11,935 | 76 | 8.04 | 2.42 | 3.32 | 1.18 | 21.2 | 6.4 | 1.25 | .295 | 4.53 | 8.82 |
| 5 | | A.J. Burnett | 2,513 | 435 | 164 | 157 | .511 | 430 | 3.99 | 24 | 10 | 0 | 2731.1 | 2,519 | 1,210 | 1,328 | 263 | 1,100 | 143 | 1 | 35 | 11,665 | 161 | 8.28 | 3.62 | 2.28 | 0.87 | 21.5 | 9.4 | 1.32 | .295 | 4.38 | 8.30 |
| 6 | | C. Schilling | 2,498 | 363 | 173 | 104 | .625 | 341 | 3.43 | 64 | 14 | 9 | 2456.0 | 2,267 | 935 | 970 | 283 | 470 | 40 | 21 | 20 | 9,933 | 49 | 9.15 | 1.72 | 5.31 | 1.04 | 25.1 | 4.7 | 1.11 | .299 | 3.55 | 8.31 |
| 7 |  | R. Clemens | 2,387 | 368 | 178 | 87 | .672 | 367 | 3.26 | 24 | 10 | 0 | 2434.1 | 2,090 | 881 | 969 | 190 | 854 | 79 | 0 | 22 | 10,108 | 82 | 8.83 | 3.16 | 2.80 | 0.70 | 23.6 | 8.4 | 1.21 | .288 | 3.58 | 7.73 |
| 8 | | A. Pettitte | 2,378 | 509 | 250 | 147 | .630 | 504 | 3.85 | 24 | 4 | 0 | 3201.1 | 3,322 | 1,368 | 1,517 | 279 | 986 | 54 | 2 | 39 | 13,578 | 66 | 6.69 | 2.77 | 2.41 | 0.78 | 17.5 | 7.3 | 1.35 | .308 | 4.26 | 9.34 |
| 9 |  | B. Colon | 2,353 | 506 | 232 | 161 | .590 | 497 | 3.92 | 36 | 13 | 0 | 3158.1 | 3,210 | 1,376 | 1,499 | 376 | 888 | 60 | 1 | 46 | 13,319 | 42 | 6.71 | 2.53 | 2.65 | 1.07 | 17.7 | 6.7 | 1.30 | .294 | 4.27 | 9.15 |
| 10 | | M. Mussina | 2,319 | 421 | 205 | 125 | .621 | 420 | 3.79 | 39 | 16 | 0 | 2740.1 | 2,710 | 1,155 | 1,242 | 295 | 596 | 52 | 0 | 20 | 11,277 | 56 | 7.62 | 1.96 | 3.89 | 0.97 | 20.6 | 5.3 | 1.21 | .301 | 4.08 | 8.90 |
| 11 |  | F. Hernandez | 2,254 | 356 | 154 | 107 | .590 | 356 | 3.15 | 25 | 11 | 0 | 2400.0 | 2,141 | 841 | 935 | 202 | 690 | 80 | 0 | 16 | 9,839 | 132 | 8.45 | 2.59 | 3.27 | 0.76 | 22.9 | 7.0 | 1.18 | .293 | 3.51 | 8.03 |
| 12 | | J. Peavy | 2,207 | 387 | 152 | 126 | .547 | 377 | 3.63 | 15 | 6 | 0 | 2376.0 | 2,133 | 959 | 1,010 | 259 | 707 | 78 | 3 | 42 | 9,833 | 46 | 8.36 | 2.68 | 3.12 | 0.98 | 22.4 | 7.2 | 1.20 | .285 | 3.83 | 8.08 |
| 13 |  | J. Verlander | 2,166 | 349 | 171 | 105 | .620 | 349 | 3.49 | 23 | 7 | 0 | 2318.1 | 2,058 | 899 | 978 | 215 | 695 | 79 | 0 | 22 | 9,586 | 73 | 8.41 | 2.70 | 3.12 | 0.83 | 22.6 | 7.3 | 1.19 | .287 | 3.80 | 7.99 |
| 14 | | J. Lackey | 2,138 | 415 | 174 | 135 | .563 | 414 | 3.88 | 18 | 8 | 0 | 2657.2 | 2,687 | 1,147 | 1,251 | 283 | 758 | 121 | 0 | 29 | 11,251 | 113 | 7.24 | 2.57 | 2.82 | 0.96 | 19.0 | 6.7 | 1.30 | .302 | 4.24 | 9.10 |
| 15 | | R. Halladay | 2,117 | 416 | 203 | 105 | .659 | 390 | 3.38 | 67 | 20 | 1 | 2749.1 | 2,646 | 1,034 | 1,135 | 236 | 592 | 81 | 6 | 28 | 11,287 | 56 | 6.93 | 1.94 | 3.58 | 0.77 | 18.8 | 5.2 | 1.18 | .292 | 3.72 | 8.66 |
| 16 | | C. Hamels | 2,109 | 337 | 135 | 96 | .584 | 336 | 3.32 | 15 | 7 | 0 | 2200.1 | 1,965 | 812 | 864 | 245 | 590 | 63 | 0 | 41 | 9,010 | 42 | 8.63 | 2.41 | 3.57 | 1.00 | 23.4 | 6.5 | 1.16 | .287 | 3.53 | 8.04 |
| 17 | | K. Millwood | 2,083 | 451 | 169 | 152 | .526 | 443 | 4.11 | 22 | 6 | 0 | 2720.1 | 2,770 | 1,243 | 1,357 | 296 | 843 | 74 | 3 | 46 | 11,616 | 67 | 6.89 | 2.79 | 2.47 | 0.98 | 17.9 | 7.3 | 1.33 | .297 | 4.49 | 9.16 |
| 18 | | T. Hudson | 2,080 | 482 | 222 | 133 | .625 | 479 | 3.49 | 26 | 13 | 0 | 3126.2 | 2,957 | 1,213 | 1,319 | 248 | 917 | 124 | 0 | 84 | 13,005 | 84 | 5.99 | 2.64 | 2.27 | 0.71 | 16.0 | 7.1 | 1.24 | .281 | 3.80 | 8.51 |
| 19 | | R. Dempster | 2,075 | 579 | 132 | 133 | .498 | 351 | 4.35 | 11 | 3 | 87 | 2387.0 | 2,347 | 1,154 | 1,250 | 267 | 1,071 | 91 | 186 | 47 | 10,412 | 80 | 7.82 | 4.04 | 1.94 | 1.01 | 19.9 | 10.3 | 1.43 | .301 | 4.71 | 8.85 |
| 20 |  | Z. Greinke | 2,014 | 389 | 154 | 100 | .606 | 348 | 3.42 | 15 | 5 | 1 | 2247.1 | 2,131 | 854 | 919 | 217 | 545 | 59 | 8 | 19 | 9,255 | 68 | 8.07 | 2.18 | 3.70 | 0.87 | 21.8 | 5.9 | 1.19 | .298 | 3.68 | 8.53 |
| 21 | | D. Haren | 2,013 | 391 | 153 | 131 | .539 | 380 | 3.75 | 16 | 6 | 1 | 2419.2 | 2,357 | 1,009 | 1,105 | 305 | 500 | 67 | 4 | 39 | 10,022 | 98 | 7.49 | 1.86 | 4.03 | 1.13 | 20.1 | 5.0 | 1.18 | .288 | 4.11 | 8.77 |
| 22 | | J. Santana | 1,988 | 360 | 139 | 78 | .641 | 284 | 3.20 | 15 | 10 | 1 | 2025.2 | 1,726 | 721 | 773 | 220 | 567 | 36 | 23 | 13 | 8,262 | 68 | 8.83 | 2.52 | 3.51 | 0.98 | 24.1 | 6.9 | 1.13 | .276 | 3.43 | 7.67 |
| 23 | | L. Hernandez | 1,976 | 519 | 178 | 177 | .501 | 474 | 4.44 | 50 | 9 | 1 | 3189.0 | 3,525 | 1,572 | 1,686 | 362 | 1,066 | 78 | 17 | 86 | 13,816 | 41 | 5.58 | 3.01 | 1.85 | 1.02 | 14.3 | 7.7 | 1.44 | .306 | 4.76 | 9.95 |
| 24 | | J. Shields | 1,964 | 350 | 132 | 115 | .534 | 349 | 3.91 | 23 | 9 | 0 | 2281.1 | 2,264 | 990 | 1,074 | 298 | 610 | 84 | 0 | 19 | 9,551 | 91 | 7.75 | 2.41 | 3.22 | 1.18 | 20.6 | 6.4 | 1.26 | .298 | 4.24 | 8.93 |
| 25 | | T. Wakefield | 1,964 | 572 | 172 | 166 | .509 | 412 | 4.54 | 20 | 2 | 22 | 2872.0 | 2,829 | 1,449 | 1,645 | 387 | 1,054 | 172 | 77 | 30 | 12,439 | 116 | 6.15 | 3.30 | 1.86 | 1.21 | 15.8 | 8.5 | 1.35 | .276 | 5.15 | 8.87 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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