Between August 20, 1974 and October 1, 1995, Nolan Ryan fanned the most batters, with 4,240 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | N. Ryan | 4,240 | 590 | 239 | 210 | .532 | 590 | 3.23 | 146 | 44 | 0 | 4020.0 | 2,969 | 1,443 | 1,650 | 238 | 1,986 | 110 | 0 | 55 | 16,797 | 213 | 9.49 | 4.45 | 2.13 | 0.53 | 25.2 | 11.8 | 1.23 | .267 | 3.69 | 6.65 |
| 2 |  | B. Blyleven | 2,681 | 520 | 213 | 178 | .545 | 516 | 3.49 | 172 | 40 | 0 | 3707.0 | 3,486 | 1,436 | 1,584 | 341 | 1,024 | 122 | 1 | 50 | 15,345 | 91 | 6.51 | 2.49 | 2.62 | 0.83 | 17.5 | 6.7 | 1.22 | .281 | 3.85 | 8.46 |
| 3 | | F. Tanana | 2,638 | 605 | 229 | 220 | .510 | 587 | 3.67 | 134 | 31 | 1 | 3971.0 | 3,853 | 1,618 | 1,818 | 424 | 1,189 | 123 | 8 | 114 | 16,726 | 114 | 5.98 | 2.69 | 2.22 | 0.96 | 15.8 | 7.1 | 1.27 | .278 | 4.12 | 8.73 |
| 4 |  | J. Morris | 2,478 | 549 | 254 | 186 | .577 | 527 | 3.90 | 175 | 28 | 0 | 3824.0 | 3,567 | 1,657 | 1,815 | 389 | 1,390 | 58 | 10 | 99 | 16,120 | 205 | 5.83 | 3.27 | 1.78 | 0.92 | 15.4 | 8.6 | 1.30 | .269 | 4.27 | 8.40 |
| 5 |  | S. Carlton | 2,470 | 441 | 198 | 144 | .579 | 427 | 3.34 | 126 | 27 | 1 | 3096.2 | 2,767 | 1,149 | 1,317 | 264 | 1,084 | 28 | 6 | 86 | 12,849 | 105 | 7.18 | 3.15 | 2.28 | 0.77 | 19.2 | 8.4 | 1.24 | .278 | 3.83 | 8.04 |
| 6 |  | R. Clemens | 2,333 | 349 | 182 | 98 | .650 | 348 | 3.00 | 94 | 36 | 0 | 2533.1 | 2,143 | 845 | 939 | 175 | 750 | 82 | 0 | 41 | 10,352 | 64 | 8.29 | 2.66 | 3.11 | 0.62 | 22.5 | 7.2 | 1.14 | .281 | 3.34 | 7.61 |
| 7 | | D. Eckersley | 2,285 | 901 | 192 | 159 | .547 | 361 | 3.48 | 100 | 20 | 323 | 3133.0 | 2,916 | 1,213 | 1,311 | 324 | 716 | 67 | 464 | 85 | 12,894 | 26 | 6.56 | 2.06 | 3.19 | 0.93 | 17.7 | 5.6 | 1.16 | .273 | 3.77 | 8.38 |
| 8 | | M. Langston | 2,250 | 382 | 166 | 140 | .542 | 379 | 3.80 | 79 | 18 | 0 | 2642.0 | 2,362 | 1,116 | 1,236 | 265 | 1,142 | 42 | 1 | 26 | 11,135 | 79 | 7.66 | 3.89 | 1.97 | 0.90 | 20.2 | 10.3 | 1.33 | .282 | 4.21 | 8.05 |
| 9 | | C. Hough | 2,239 | 773 | 206 | 211 | .494 | 440 | 3.75 | 107 | 13 | 53 | 3642.0 | 3,161 | 1,519 | 1,736 | 365 | 1,574 | 164 | 199 | 40 | 15,487 | 175 | 5.53 | 3.89 | 1.42 | 0.90 | 14.5 | 10.2 | 1.30 | .251 | 4.29 | 7.81 |
| 10 | | D. Martinez | 2,022 | 610 | 231 | 176 | .568 | 528 | 3.60 | 120 | 28 | 6 | 3747.2 | 3,601 | 1,500 | 1,673 | 344 | 1,080 | 110 | 40 | 62 | 15,636 | 82 | 4.86 | 2.59 | 1.87 | 0.83 | 12.9 | 6.9 | 1.25 | .270 | 4.02 | 8.65 |
| 11 | | P. Niekro | 2,022 | 476 | 195 | 170 | .534 | 464 | 3.61 | 134 | 22 | 2 | 3275.1 | 3,153 | 1,313 | 1,501 | 303 | 1,252 | 78 | 9 | 48 | 13,940 | 124 | 5.56 | 3.44 | 1.62 | 0.83 | 14.5 | 9.0 | 1.34 | .277 | 4.12 | 8.66 |
| 12 | | B. Welch | 1,969 | 506 | 211 | 146 | .591 | 462 | 3.47 | 61 | 28 | 8 | 3092.0 | 2,894 | 1,191 | 1,310 | 267 | 1,034 | 79 | 20 | 60 | 12,956 | 55 | 5.73 | 3.01 | 1.90 | 0.78 | 15.2 | 8.0 | 1.27 | .273 | 3.81 | 8.42 |
| 13 | | F. Valenzuela | 1,918 | 402 | 158 | 133 | .543 | 375 | 3.49 | 112 | 31 | 2 | 2669.1 | 2,435 | 1,036 | 1,164 | 197 | 1,038 | 20 | 10 | 63 | 11,238 | 108 | 6.47 | 3.50 | 1.85 | 0.66 | 17.1 | 9.2 | 1.30 | .277 | 3.92 | 8.21 |
| 14 | | D. Sutton | 1,903 | 453 | 194 | 143 | .576 | 449 | 3.39 | 82 | 24 | 2 | 3076.0 | 2,790 | 1,160 | 1,271 | 308 | 774 | 40 | 3 | 48 | 12,635 | 54 | 5.57 | 2.26 | 2.46 | 0.90 | 15.1 | 6.1 | 1.16 | .258 | 3.72 | 8.16 |
| 15 | | D. Gooden | 1,875 | 305 | 157 | 85 | .649 | 303 | 3.10 | 67 | 23 | 1 | 2169.2 | 1,898 | 747 | 823 | 123 | 651 | 41 | 1 | 31 | 8,898 | 47 | 7.78 | 2.70 | 2.88 | 0.51 | 21.1 | 7.3 | 1.17 | .286 | 3.41 | 7.87 |
| 16 |  | T. Seaver | 1,838 | 381 | 169 | 121 | .583 | 377 | 3.17 | 102 | 34 | 0 | 2676.2 | 2,293 | 944 | 1,041 | 221 | 842 | 37 | 1 | 71 | 10,967 | 77 | 6.18 | 2.83 | 2.18 | 0.74 | 16.8 | 7.7 | 1.17 | .258 | 3.50 | 7.71 |
| 17 | | F. Viola | 1,826 | 415 | 175 | 147 | .543 | 414 | 3.69 | 74 | 16 | 0 | 2806.0 | 2,784 | 1,149 | 1,275 | 288 | 843 | 46 | 0 | 36 | 11,783 | 85 | 5.86 | 2.70 | 2.17 | 0.92 | 15.5 | 7.2 | 1.29 | .284 | 4.09 | 8.93 |
| 18 | | R. Guidry | 1,778 | 368 | 170 | 91 | .651 | 323 | 3.29 | 95 | 26 | 4 | 2392.0 | 2,198 | 874 | 953 | 226 | 633 | 13 | 23 | 24 | 9,794 | 56 | 6.69 | 2.38 | 2.81 | 0.85 | 18.2 | 6.5 | 1.18 | .276 | 3.59 | 8.27 |
| 19 | | D. Cone | 1,741 | 288 | 129 | 78 | .623 | 259 | 3.18 | 50 | 21 | 1 | 1922.0 | 1,589 | 679 | 746 | 151 | 716 | 55 | 9 | 29 | 7,959 | 98 | 8.15 | 3.35 | 2.43 | 0.71 | 21.9 | 9.0 | 1.20 | .272 | 3.49 | 7.44 |
| 20 | | D. Stewart | 1,741 | 523 | 168 | 129 | .566 | 348 | 3.95 | 55 | 9 | 19 | 2629.2 | 2,499 | 1,154 | 1,259 | 264 | 1,034 | 62 | 87 | 46 | 11,251 | 119 | 5.96 | 3.54 | 1.68 | 0.90 | 15.5 | 9.2 | 1.34 | .274 | 4.31 | 8.55 |
| 21 | | F. Bannister | 1,723 | 431 | 134 | 143 | .484 | 363 | 4.06 | 62 | 16 | 0 | 2388.0 | 2,320 | 1,078 | 1,189 | 291 | 846 | 40 | 13 | 39 | 10,187 | 84 | 6.49 | 3.19 | 2.04 | 1.10 | 16.9 | 8.3 | 1.33 | .278 | 4.48 | 8.74 |
| 22 | | B. Hurst | 1,689 | 379 | 145 | 113 | .562 | 359 | 3.92 | 83 | 23 | 0 | 2417.1 | 2,463 | 1,052 | 1,143 | 258 | 740 | 28 | 5 | 42 | 10,204 | 56 | 6.29 | 2.76 | 2.28 | 0.96 | 16.6 | 7.3 | 1.33 | .294 | 4.26 | 9.17 |
| 23 | | R. Sutcliffe | 1,679 | 457 | 171 | 139 | .552 | 392 | 4.08 | 72 | 18 | 6 | 2697.2 | 2,662 | 1,223 | 1,324 | 236 | 1,081 | 46 | 30 | 75 | 11,548 | 100 | 5.60 | 3.61 | 1.55 | 0.79 | 14.5 | 9.4 | 1.39 | .285 | 4.42 | 8.88 |
| 24 | | D. Darwin | 1,673 | 618 | 148 | 150 | .497 | 297 | 3.71 | 52 | 9 | 32 | 2546.0 | 2,434 | 1,050 | 1,170 | 256 | 753 | 64 | 168 | 93 | 10,687 | 44 | 5.91 | 2.66 | 2.22 | 0.90 | 15.7 | 7.0 | 1.25 | .274 | 4.14 | 8.60 |
| 25 | | J. Candelaria | 1,673 | 600 | 177 | 122 | .592 | 356 | 3.33 | 54 | 13 | 29 | 2525.2 | 2,399 | 935 | 1,038 | 245 | 592 | 37 | 82 | 63 | 10,366 | 28 | 5.96 | 2.11 | 2.83 | 0.87 | 16.1 | 5.7 | 1.18 | .275 | 3.70 | 8.55 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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