Between August 28, 1992 and June 30, 2016, Randy Johnson struck out the most hitters, with 4,132 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | R. Johnson | 4,132 | 495 | 256 | 120 | .681 | 481 | 3.13 | 85 | 32 | 2 | 3370.1 | 2,728 | 1,173 | 1,312 | 344 | 1,009 | 154 | 6 | 32 | 13,708 | 74 | 11.03 | 2.69 | 4.10 | 0.92 | 30.1 | 7.4 | 1.11 | .295 | 3.50 | 7.28 |
| 2 |  | P. Martinez | 3,154 | 476 | 219 | 100 | .687 | 409 | 2.93 | 46 | 17 | 3 | 2827.1 | 2,221 | 919 | 1,006 | 239 | 760 | 141 | 23 | 30 | 11,394 | 62 | 10.04 | 2.42 | 4.15 | 0.76 | 27.7 | 6.7 | 1.05 | .279 | 3.20 | 7.07 |
| 3 |  | C. Schilling | 2,885 | 434 | 201 | 127 | .613 | 412 | 3.48 | 76 | 16 | 9 | 2945.2 | 2,723 | 1,138 | 1,191 | 330 | 594 | 50 | 21 | 32 | 11,961 | 62 | 8.81 | 1.81 | 4.86 | 1.01 | 24.1 | 5.0 | 1.13 | .295 | 3.64 | 8.32 |
| 4 |  | R. Clemens | 2,836 | 442 | 205 | 115 | .641 | 441 | 3.35 | 31 | 12 | 0 | 2929.0 | 2,529 | 1,090 | 1,198 | 235 | 1,040 | 109 | 0 | 29 | 12,201 | 96 | 8.71 | 3.20 | 2.73 | 0.72 | 23.2 | 8.5 | 1.22 | .287 | 3.68 | 7.77 |
| 5 | | M. Mussina | 2,668 | 500 | 254 | 143 | .640 | 499 | 3.75 | 50 | 20 | 0 | 3294.0 | 3,214 | 1,371 | 1,467 | 354 | 733 | 57 | 0 | 29 | 13,517 | 63 | 7.29 | 2.00 | 3.64 | 0.97 | 19.7 | 5.4 | 1.20 | .295 | 4.01 | 8.78 |
| 6 |  | CC Sabathia | 2,635 | 465 | 219 | 134 | .620 | 465 | 3.68 | 38 | 12 | 0 | 3065.1 | 2,900 | 1,252 | 1,370 | 297 | 924 | 101 | 0 | 42 | 12,792 | 65 | 7.74 | 2.71 | 2.85 | 0.87 | 20.6 | 7.2 | 1.25 | .295 | 4.02 | 8.51 |
| 7 | | J. Vazquez | 2,536 | 450 | 165 | 160 | .508 | 443 | 4.22 | 28 | 8 | 0 | 2840.0 | 2,784 | 1,331 | 1,431 | 373 | 763 | 88 | 5 | 58 | 11,935 | 76 | 8.04 | 2.42 | 3.32 | 1.18 | 21.2 | 6.4 | 1.25 | .295 | 4.53 | 8.82 |
| 8 | | A.J. Burnett | 2,513 | 435 | 164 | 157 | .511 | 430 | 3.99 | 24 | 10 | 0 | 2731.1 | 2,519 | 1,210 | 1,328 | 263 | 1,100 | 143 | 1 | 35 | 11,665 | 161 | 8.28 | 3.62 | 2.28 | 0.87 | 21.5 | 9.4 | 1.32 | .295 | 4.38 | 8.30 |
| 9 |  | G. Maddux | 2,482 | 539 | 265 | 153 | .634 | 539 | 3.06 | 69 | 24 | 0 | 3619.1 | 3,423 | 1,232 | 1,379 | 273 | 554 | 99 | 0 | 108 | 14,608 | 42 | 6.17 | 1.38 | 4.48 | 0.68 | 17.0 | 3.8 | 1.10 | .281 | 3.43 | 8.51 |
| 10 | | A. Pettitte | 2,448 | 531 | 256 | 153 | .626 | 521 | 3.85 | 26 | 4 | 0 | 3316.0 | 3,448 | 1,418 | 1,572 | 288 | 1,031 | 55 | 3 | 42 | 14,074 | 69 | 6.64 | 2.80 | 2.37 | 0.78 | 17.4 | 7.3 | 1.35 | .308 | 4.27 | 9.36 |
| 11 |  | J. Smoltz | 2,391 | 585 | 157 | 105 | .599 | 343 | 3.27 | 29 | 11 | 154 | 2540.2 | 2,268 | 922 | 996 | 214 | 674 | 44 | 204 | 69 | 10,397 | 90 | 8.47 | 2.39 | 3.55 | 0.76 | 23.0 | 6.5 | 1.16 | .290 | 3.53 | 8.03 |
| 12 |  | B. Colon | 2,295 | 491 | 224 | 158 | .586 | 482 | 3.94 | 36 | 13 | 0 | 3068.2 | 3,118 | 1,342 | 1,458 | 364 | 870 | 58 | 1 | 44 | 12,945 | 42 | 6.73 | 2.55 | 2.64 | 1.07 | 17.7 | 6.7 | 1.30 | .294 | 4.28 | 9.14 |
| 13 |  | F. Hernandez | 2,195 | 344 | 147 | 105 | .583 | 344 | 3.11 | 25 | 11 | 0 | 2325.1 | 2,070 | 803 | 896 | 190 | 656 | 75 | 0 | 16 | 9,517 | 128 | 8.50 | 2.54 | 3.35 | 0.74 | 23.1 | 6.9 | 1.17 | .294 | 3.47 | 8.01 |
| 14 | | J. Peavy | 2,168 | 373 | 151 | 124 | .549 | 372 | 3.60 | 15 | 6 | 0 | 2341.0 | 2,095 | 937 | 988 | 251 | 698 | 78 | 0 | 42 | 9,680 | 44 | 8.33 | 2.68 | 3.11 | 0.96 | 22.4 | 7.2 | 1.19 | .284 | 3.80 | 8.05 |
| 15 | | T. Wakefield | 2,124 | 621 | 196 | 179 | .523 | 457 | 4.45 | 30 | 5 | 22 | 3177.1 | 3,115 | 1,571 | 1,778 | 417 | 1,183 | 186 | 78 | 33 | 13,741 | 131 | 6.02 | 3.35 | 1.80 | 1.18 | 15.5 | 8.6 | 1.35 | .274 | 5.04 | 8.82 |
| 16 | | R. Halladay | 2,117 | 416 | 203 | 105 | .659 | 390 | 3.38 | 67 | 20 | 1 | 2749.1 | 2,646 | 1,034 | 1,135 | 236 | 592 | 81 | 6 | 28 | 11,287 | 56 | 6.93 | 1.94 | 3.58 | 0.77 | 18.8 | 5.2 | 1.18 | .292 | 3.72 | 8.66 |
| 17 | | K. Millwood | 2,083 | 451 | 169 | 152 | .526 | 443 | 4.11 | 22 | 6 | 0 | 2720.1 | 2,770 | 1,243 | 1,357 | 296 | 843 | 74 | 3 | 46 | 11,616 | 67 | 6.89 | 2.79 | 2.47 | 0.98 | 17.9 | 7.3 | 1.33 | .297 | 4.49 | 9.16 |
| 18 | | T. Hudson | 2,080 | 482 | 222 | 133 | .625 | 479 | 3.49 | 26 | 13 | 0 | 3126.2 | 2,957 | 1,213 | 1,319 | 248 | 917 | 124 | 0 | 84 | 13,005 | 84 | 5.99 | 2.64 | 2.27 | 0.71 | 16.0 | 7.1 | 1.24 | .281 | 3.80 | 8.51 |
| 19 | | R. Dempster | 2,075 | 579 | 132 | 133 | .498 | 351 | 4.35 | 11 | 3 | 87 | 2387.0 | 2,347 | 1,154 | 1,250 | 267 | 1,071 | 91 | 186 | 47 | 10,412 | 80 | 7.82 | 4.04 | 1.94 | 1.01 | 19.9 | 10.3 | 1.43 | .301 | 4.71 | 8.85 |
| 20 | | J. Lackey | 2,072 | 404 | 172 | 131 | .568 | 403 | 3.89 | 18 | 8 | 0 | 2586.0 | 2,631 | 1,118 | 1,219 | 271 | 738 | 118 | 0 | 29 | 10,964 | 113 | 7.21 | 2.57 | 2.81 | 0.94 | 18.9 | 6.7 | 1.30 | .304 | 4.24 | 9.16 |
| 21 |  | J. Verlander | 2,050 | 334 | 164 | 103 | .614 | 334 | 3.55 | 22 | 7 | 0 | 2216.0 | 1,991 | 875 | 950 | 203 | 670 | 76 | 0 | 22 | 9,186 | 73 | 8.33 | 2.72 | 3.06 | 0.82 | 22.3 | 7.3 | 1.20 | .289 | 3.86 | 8.09 |
| 22 | | C. Hamels | 2,024 | 323 | 130 | 92 | .586 | 322 | 3.28 | 15 | 7 | 0 | 2117.1 | 1,881 | 771 | 821 | 237 | 553 | 63 | 0 | 40 | 8,648 | 40 | 8.60 | 2.35 | 3.66 | 1.01 | 23.4 | 6.4 | 1.15 | .285 | 3.49 | 8.00 |
| 23 | | D. Haren | 2,013 | 391 | 153 | 131 | .539 | 380 | 3.75 | 16 | 6 | 1 | 2419.2 | 2,357 | 1,009 | 1,105 | 305 | 500 | 67 | 4 | 39 | 10,022 | 98 | 7.49 | 1.86 | 4.03 | 1.13 | 20.1 | 5.0 | 1.18 | .288 | 4.11 | 8.77 |
| 24 | | J. Moyer | 2,006 | 555 | 235 | 155 | .603 | 527 | 4.19 | 26 | 8 | 0 | 3374.0 | 3,465 | 1,571 | 1,682 | 443 | 873 | 127 | 6 | 48 | 14,281 | 35 | 5.35 | 2.33 | 2.30 | 1.18 | 14.0 | 6.1 | 1.29 | .279 | 4.49 | 9.24 |
| 25 | | J. Santana | 1,988 | 360 | 139 | 78 | .641 | 284 | 3.20 | 15 | 10 | 1 | 2025.2 | 1,726 | 721 | 773 | 220 | 567 | 36 | 23 | 13 | 8,262 | 68 | 8.83 | 2.52 | 3.51 | 0.98 | 24.1 | 6.9 | 1.13 | .276 | 3.43 | 7.67 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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