Between August 31, 1991 and August 5, 2015, Randy Johnson fanned the most hitters, with 4,338 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | R. Johnson | 4,338 | 526 | 267 | 133 | .668 | 512 | 3.19 | 90 | 34 | 2 | 3565.2 | 2,882 | 1,264 | 1,418 | 356 | 1,154 | 173 | 6 | 33 | 14,583 | 85 | 10.95 | 2.91 | 3.76 | 0.90 | 29.7 | 7.9 | 1.13 | .295 | 3.58 | 7.27 |
| 2 |  | P. Martinez | 3,154 | 476 | 219 | 100 | .687 | 409 | 2.93 | 46 | 17 | 3 | 2827.1 | 2,221 | 919 | 1,006 | 239 | 760 | 141 | 23 | 30 | 11,394 | 62 | 10.04 | 2.42 | 4.15 | 0.76 | 27.7 | 6.7 | 1.05 | .279 | 3.20 | 7.07 |
| 3 |  | R. Clemens | 3,065 | 476 | 225 | 125 | .643 | 475 | 3.27 | 45 | 19 | 0 | 3198.1 | 2,736 | 1,162 | 1,278 | 251 | 1,101 | 116 | 0 | 36 | 13,255 | 100 | 8.62 | 3.10 | 2.78 | 0.71 | 23.1 | 8.3 | 1.20 | .285 | 3.60 | 7.70 |
| 4 |  | C. Schilling | 3,023 | 484 | 212 | 135 | .611 | 431 | 3.42 | 83 | 20 | 13 | 3138.0 | 2,867 | 1,193 | 1,252 | 339 | 650 | 51 | 40 | 37 | 12,735 | 65 | 8.67 | 1.86 | 4.65 | 0.97 | 23.7 | 5.1 | 1.12 | .292 | 3.59 | 8.22 |
| 5 | | M. Mussina | 2,787 | 532 | 268 | 150 | .641 | 531 | 3.68 | 57 | 23 | 0 | 3530.0 | 3,429 | 1,444 | 1,544 | 372 | 773 | 59 | 0 | 29 | 14,452 | 69 | 7.11 | 1.97 | 3.61 | 0.95 | 19.3 | 5.3 | 1.19 | .292 | 3.94 | 8.74 |
| 6 |  | G. Maddux | 2,674 | 575 | 284 | 166 | .631 | 575 | 3.00 | 79 | 27 | 0 | 3895.2 | 3,617 | 1,300 | 1,453 | 280 | 623 | 108 | 0 | 114 | 15,678 | 47 | 6.18 | 1.44 | 4.29 | 0.65 | 17.1 | 4.0 | 1.09 | .278 | 3.36 | 8.36 |
| 7 |  | J. Smoltz | 2,592 | 619 | 175 | 113 | .608 | 377 | 3.19 | 38 | 14 | 154 | 2791.2 | 2,466 | 990 | 1,071 | 227 | 752 | 49 | 204 | 74 | 11,414 | 104 | 8.36 | 2.42 | 3.45 | 0.73 | 22.7 | 6.6 | 1.15 | .287 | 3.45 | 7.95 |
| 8 | | J. Vazquez | 2,536 | 450 | 165 | 160 | .508 | 443 | 4.22 | 28 | 8 | 0 | 2840.0 | 2,784 | 1,331 | 1,431 | 373 | 763 | 88 | 5 | 58 | 11,935 | 76 | 8.04 | 2.42 | 3.32 | 1.18 | 21.2 | 6.4 | 1.25 | .295 | 4.53 | 8.82 |
| 9 |  | CC Sabathia | 2,534 | 443 | 212 | 127 | .625 | 443 | 3.70 | 38 | 12 | 0 | 2938.1 | 2,786 | 1,209 | 1,322 | 289 | 869 | 93 | 0 | 40 | 12,250 | 63 | 7.76 | 2.66 | 2.92 | 0.89 | 20.7 | 7.1 | 1.24 | .295 | 4.05 | 8.53 |
| 10 | | A.J. Burnett | 2,484 | 430 | 163 | 155 | .513 | 425 | 3.99 | 24 | 10 | 0 | 2702.2 | 2,490 | 1,198 | 1,315 | 259 | 1,087 | 141 | 1 | 35 | 11,540 | 160 | 8.27 | 3.62 | 2.29 | 0.86 | 21.5 | 9.4 | 1.32 | .295 | 4.38 | 8.29 |
| 11 | | A. Pettitte | 2,448 | 531 | 256 | 153 | .626 | 521 | 3.85 | 26 | 4 | 0 | 3316.0 | 3,448 | 1,418 | 1,572 | 288 | 1,031 | 55 | 3 | 42 | 14,074 | 69 | 6.64 | 2.80 | 2.37 | 0.78 | 17.4 | 7.3 | 1.35 | .308 | 4.27 | 9.36 |
| 12 |  | B. Colon | 2,199 | 463 | 214 | 151 | .586 | 457 | 3.99 | 35 | 12 | 0 | 2913.2 | 2,960 | 1,291 | 1,406 | 347 | 846 | 56 | 0 | 44 | 12,319 | 42 | 6.79 | 2.61 | 2.60 | 1.07 | 17.9 | 6.9 | 1.31 | .295 | 4.34 | 9.14 |
| 13 | | T. Wakefield | 2,156 | 627 | 200 | 180 | .526 | 463 | 4.41 | 33 | 6 | 22 | 3226.1 | 3,152 | 1,582 | 1,791 | 418 | 1,205 | 186 | 78 | 33 | 13,939 | 134 | 6.01 | 3.36 | 1.79 | 1.17 | 15.5 | 8.6 | 1.35 | .274 | 5.00 | 8.79 |
| 14 | | T. Glavine | 2,129 | 550 | 255 | 154 | .623 | 550 | 3.48 | 40 | 20 | 0 | 3569.2 | 3,483 | 1,379 | 1,498 | 288 | 1,240 | 50 | 0 | 118 | 15,045 | 44 | 5.37 | 3.13 | 1.72 | 0.73 | 14.2 | 8.2 | 1.32 | .282 | 3.78 | 8.78 |
| 15 | | R. Halladay | 2,117 | 416 | 203 | 105 | .659 | 390 | 3.38 | 67 | 20 | 1 | 2749.1 | 2,646 | 1,034 | 1,135 | 236 | 592 | 81 | 6 | 28 | 11,287 | 56 | 6.93 | 1.94 | 3.58 | 0.77 | 18.8 | 5.2 | 1.18 | .292 | 3.72 | 8.66 |
| 16 | | K. Brown | 2,113 | 401 | 176 | 114 | .607 | 391 | 3.18 | 58 | 15 | 0 | 2690.2 | 2,517 | 951 | 1,089 | 170 | 691 | 119 | 1 | 32 | 11,127 | 81 | 7.07 | 2.31 | 3.06 | 0.57 | 19.0 | 6.2 | 1.19 | .292 | 3.64 | 8.42 |
| 17 |  | F. Hernandez | 2,091 | 325 | 138 | 98 | .585 | 325 | 3.08 | 25 | 11 | 0 | 2204.1 | 1,963 | 754 | 841 | 174 | 613 | 67 | 0 | 16 | 9,007 | 120 | 8.54 | 2.50 | 3.41 | 0.71 | 23.2 | 6.8 | 1.17 | .295 | 3.43 | 8.01 |
| 18 | | K. Millwood | 2,083 | 451 | 169 | 152 | .526 | 443 | 4.11 | 22 | 6 | 0 | 2720.1 | 2,770 | 1,243 | 1,357 | 296 | 843 | 74 | 3 | 46 | 11,616 | 67 | 6.89 | 2.79 | 2.47 | 0.98 | 17.9 | 7.3 | 1.33 | .297 | 4.49 | 9.16 |
| 19 | | R. Dempster | 2,075 | 579 | 132 | 133 | .498 | 351 | 4.35 | 11 | 3 | 87 | 2387.0 | 2,347 | 1,154 | 1,250 | 267 | 1,071 | 91 | 186 | 47 | 10,412 | 80 | 7.82 | 4.04 | 1.94 | 1.01 | 19.9 | 10.3 | 1.43 | .301 | 4.71 | 8.85 |
| 20 | | T. Hudson | 2,069 | 475 | 220 | 132 | .625 | 474 | 3.50 | 26 | 13 | 0 | 3104.1 | 2,940 | 1,206 | 1,311 | 248 | 906 | 122 | 0 | 84 | 12,913 | 84 | 6.00 | 2.63 | 2.28 | 0.72 | 16.0 | 7.0 | 1.24 | .281 | 3.80 | 8.52 |
| 21 | | J. Peavy | 2,060 | 346 | 141 | 115 | .551 | 345 | 3.54 | 15 | 6 | 0 | 2193.0 | 1,944 | 862 | 910 | 234 | 658 | 75 | 0 | 41 | 9,055 | 40 | 8.45 | 2.70 | 3.13 | 0.96 | 22.7 | 7.3 | 1.19 | .284 | 3.73 | 7.98 |
| 22 | | J. Moyer | 2,006 | 555 | 235 | 155 | .603 | 527 | 4.19 | 26 | 8 | 0 | 3374.0 | 3,465 | 1,571 | 1,682 | 443 | 873 | 127 | 6 | 48 | 14,281 | 35 | 5.35 | 2.33 | 2.30 | 1.18 | 14.0 | 6.1 | 1.29 | .279 | 4.49 | 9.24 |
| 23 | | J. Santana | 1,988 | 360 | 139 | 78 | .641 | 284 | 3.20 | 15 | 10 | 1 | 2025.2 | 1,726 | 721 | 773 | 220 | 567 | 36 | 23 | 13 | 8,262 | 68 | 8.83 | 2.52 | 3.51 | 0.98 | 24.1 | 6.9 | 1.13 | .276 | 3.43 | 7.67 |
| 24 | | L. Hernandez | 1,976 | 519 | 178 | 177 | .501 | 474 | 4.44 | 50 | 9 | 1 | 3189.0 | 3,525 | 1,572 | 1,686 | 362 | 1,066 | 78 | 17 | 86 | 13,816 | 41 | 5.58 | 3.01 | 1.85 | 1.02 | 14.3 | 7.7 | 1.44 | .306 | 4.76 | 9.95 |
| 25 | | D. Haren | 1,972 | 381 | 149 | 129 | .536 | 370 | 3.75 | 16 | 6 | 1 | 2366.1 | 2,306 | 986 | 1,080 | 297 | 489 | 66 | 4 | 38 | 9,802 | 96 | 7.50 | 1.86 | 4.03 | 1.13 | 20.1 | 5.0 | 1.18 | .288 | 4.11 | 8.77 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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