Between August 4, 1994 and October 1, 2016, Randy Johnson struck out the most batters, with 3,560 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | R. Johnson | 3,560 | 431 | 223 | 104 | .682 | 418 | 3.11 | 66 | 25 | 1 | 2899.0 | 2,384 | 1,002 | 1,131 | 305 | 808 | 131 | 5 | 29 | 11,783 | 57 | 11.05 | 2.51 | 4.41 | 0.95 | 30.2 | 6.9 | 1.10 | .298 | 3.51 | 7.40 |
| 2 |  | P. Martinez | 2,898 | 387 | 200 | 89 | .692 | 385 | 2.89 | 45 | 16 | 0 | 2584.1 | 2,032 | 831 | 912 | 223 | 664 | 126 | 1 | 23 | 10,396 | 53 | 10.09 | 2.31 | 4.36 | 0.78 | 27.9 | 6.4 | 1.04 | .279 | 3.18 | 7.08 |
| 3 |  | CC Sabathia | 2,726 | 482 | 223 | 141 | .613 | 482 | 3.70 | 38 | 12 | 0 | 3168.1 | 3,003 | 1,303 | 1,423 | 315 | 959 | 104 | 0 | 43 | 13,233 | 66 | 7.74 | 2.72 | 2.84 | 0.89 | 20.6 | 7.2 | 1.25 | .294 | 4.04 | 8.53 |
| 4 |  | C. Schilling | 2,619 | 382 | 181 | 110 | .622 | 360 | 3.43 | 66 | 14 | 9 | 2587.1 | 2,379 | 987 | 1,028 | 296 | 499 | 43 | 21 | 22 | 10,470 | 50 | 9.11 | 1.74 | 5.25 | 1.03 | 25.0 | 4.8 | 1.11 | .297 | 3.58 | 8.28 |
| 5 | | J. Vazquez | 2,536 | 450 | 165 | 160 | .508 | 443 | 4.22 | 28 | 8 | 0 | 2840.0 | 2,784 | 1,331 | 1,431 | 373 | 763 | 88 | 5 | 58 | 11,935 | 76 | 8.04 | 2.42 | 3.32 | 1.18 | 21.2 | 6.4 | 1.25 | .295 | 4.53 | 8.82 |
| 6 | | A.J. Burnett | 2,513 | 435 | 164 | 157 | .511 | 430 | 3.99 | 24 | 10 | 0 | 2731.1 | 2,519 | 1,210 | 1,328 | 263 | 1,100 | 143 | 1 | 35 | 11,665 | 161 | 8.28 | 3.62 | 2.28 | 0.87 | 21.5 | 9.4 | 1.32 | .295 | 4.38 | 8.30 |
| 7 |  | R. Clemens | 2,485 | 385 | 182 | 92 | .664 | 384 | 3.31 | 24 | 10 | 0 | 2538.1 | 2,196 | 933 | 1,022 | 205 | 898 | 92 | 0 | 22 | 10,573 | 88 | 8.81 | 3.18 | 2.77 | 0.73 | 23.5 | 8.5 | 1.22 | .289 | 3.62 | 7.79 |
| 8 | | A. Pettitte | 2,448 | 531 | 256 | 153 | .626 | 521 | 3.85 | 26 | 4 | 0 | 3316.0 | 3,448 | 1,418 | 1,572 | 288 | 1,031 | 55 | 3 | 42 | 14,074 | 69 | 6.64 | 2.80 | 2.37 | 0.78 | 17.4 | 7.3 | 1.35 | .308 | 4.27 | 9.36 |
| 9 | | M. Mussina | 2,418 | 445 | 219 | 132 | .624 | 444 | 3.79 | 41 | 17 | 0 | 2898.0 | 2,851 | 1,221 | 1,313 | 314 | 633 | 53 | 0 | 24 | 11,912 | 57 | 7.51 | 1.97 | 3.82 | 0.98 | 20.3 | 5.3 | 1.20 | .299 | 4.08 | 8.85 |
| 10 |  | B. Colon | 2,365 | 509 | 233 | 162 | .590 | 500 | 3.93 | 36 | 13 | 0 | 3172.1 | 3,229 | 1,387 | 1,510 | 379 | 888 | 60 | 1 | 46 | 13,379 | 42 | 6.71 | 2.52 | 2.66 | 1.08 | 17.7 | 6.6 | 1.30 | .294 | 4.28 | 9.16 |
| 11 |  | F. Hernandez | 2,261 | 358 | 154 | 108 | .588 | 358 | 3.15 | 25 | 11 | 0 | 2412.2 | 2,153 | 845 | 943 | 202 | 695 | 81 | 0 | 16 | 9,893 | 132 | 8.43 | 2.59 | 3.25 | 0.75 | 22.9 | 7.0 | 1.18 | .293 | 3.52 | 8.03 |
| 12 | | J. Peavy | 2,207 | 388 | 152 | 126 | .547 | 377 | 3.63 | 15 | 6 | 0 | 2377.0 | 2,134 | 960 | 1,011 | 259 | 708 | 78 | 3 | 42 | 9,838 | 46 | 8.36 | 2.68 | 3.12 | 0.98 | 22.4 | 7.2 | 1.20 | .285 | 3.83 | 8.08 |
| 13 |  | J. Verlander | 2,189 | 351 | 173 | 105 | .622 | 351 | 3.48 | 23 | 7 | 0 | 2332.0 | 2,066 | 901 | 980 | 217 | 698 | 80 | 0 | 22 | 9,637 | 73 | 8.45 | 2.69 | 3.14 | 0.84 | 22.7 | 7.2 | 1.19 | .287 | 3.78 | 7.97 |
| 14 | | J. Lackey | 2,145 | 417 | 176 | 135 | .566 | 416 | 3.88 | 18 | 8 | 0 | 2669.2 | 2,697 | 1,150 | 1,254 | 283 | 762 | 121 | 0 | 29 | 11,299 | 114 | 7.23 | 2.57 | 2.81 | 0.95 | 19.0 | 6.7 | 1.30 | .302 | 4.23 | 9.09 |
| 15 | | C. Hamels | 2,122 | 339 | 136 | 96 | .586 | 338 | 3.31 | 15 | 7 | 0 | 2214.1 | 1,979 | 815 | 869 | 246 | 592 | 63 | 0 | 41 | 9,064 | 43 | 8.62 | 2.41 | 3.58 | 1.00 | 23.4 | 6.5 | 1.16 | .287 | 3.53 | 8.04 |
| 16 | | R. Halladay | 2,117 | 416 | 203 | 105 | .659 | 390 | 3.38 | 67 | 20 | 1 | 2749.1 | 2,646 | 1,034 | 1,135 | 236 | 592 | 81 | 6 | 28 | 11,287 | 56 | 6.93 | 1.94 | 3.58 | 0.77 | 18.8 | 5.2 | 1.18 | .292 | 3.72 | 8.66 |
| 17 |  | G. Maddux | 2,092 | 473 | 226 | 136 | .624 | 473 | 3.22 | 50 | 19 | 0 | 3114.1 | 3,002 | 1,115 | 1,237 | 253 | 462 | 81 | 0 | 97 | 12,604 | 34 | 6.05 | 1.34 | 4.53 | 0.73 | 16.6 | 3.7 | 1.11 | .283 | 3.57 | 8.68 |
| 18 | | K. Millwood | 2,083 | 451 | 169 | 152 | .526 | 443 | 4.11 | 22 | 6 | 0 | 2720.1 | 2,770 | 1,243 | 1,357 | 296 | 843 | 74 | 3 | 46 | 11,616 | 67 | 6.89 | 2.79 | 2.47 | 0.98 | 17.9 | 7.3 | 1.33 | .297 | 4.49 | 9.16 |
| 19 | | T. Hudson | 2,080 | 482 | 222 | 133 | .625 | 479 | 3.49 | 26 | 13 | 0 | 3126.2 | 2,957 | 1,213 | 1,319 | 248 | 917 | 124 | 0 | 84 | 13,005 | 84 | 5.99 | 2.64 | 2.27 | 0.71 | 16.0 | 7.1 | 1.24 | .281 | 3.80 | 8.51 |
| 20 | | R. Dempster | 2,075 | 579 | 132 | 133 | .498 | 351 | 4.35 | 11 | 3 | 87 | 2387.0 | 2,347 | 1,154 | 1,250 | 267 | 1,071 | 91 | 186 | 47 | 10,412 | 80 | 7.82 | 4.04 | 1.94 | 1.01 | 19.9 | 10.3 | 1.43 | .301 | 4.71 | 8.85 |
| 21 | | T. Wakefield | 2,046 | 590 | 186 | 168 | .525 | 430 | 4.43 | 26 | 3 | 22 | 3006.0 | 2,931 | 1,480 | 1,682 | 401 | 1,095 | 176 | 77 | 30 | 12,971 | 125 | 6.13 | 3.28 | 1.87 | 1.20 | 15.8 | 8.4 | 1.34 | .273 | 5.04 | 8.78 |
| 22 |  | J. Smoltz | 2,025 | 521 | 135 | 80 | .628 | 279 | 3.16 | 24 | 10 | 154 | 2115.0 | 1,894 | 743 | 799 | 172 | 510 | 34 | 204 | 53 | 8,597 | 64 | 8.62 | 2.17 | 3.97 | 0.73 | 23.6 | 5.9 | 1.14 | .294 | 3.40 | 8.06 |
| 23 |  | Z. Greinke | 2,021 | 390 | 155 | 100 | .608 | 349 | 3.42 | 15 | 5 | 1 | 2253.1 | 2,133 | 856 | 921 | 218 | 549 | 59 | 8 | 20 | 9,279 | 68 | 8.07 | 2.19 | 3.68 | 0.87 | 21.8 | 5.9 | 1.19 | .298 | 3.68 | 8.52 |
| 24 | | D. Haren | 2,013 | 391 | 153 | 131 | .539 | 380 | 3.75 | 16 | 6 | 1 | 2419.2 | 2,357 | 1,009 | 1,105 | 305 | 500 | 67 | 4 | 39 | 10,022 | 98 | 7.49 | 1.86 | 4.03 | 1.13 | 20.1 | 5.0 | 1.18 | .288 | 4.11 | 8.77 |
| 25 | | J. Santana | 1,988 | 360 | 139 | 78 | .641 | 284 | 3.20 | 15 | 10 | 1 | 2025.2 | 1,726 | 721 | 773 | 220 | 567 | 36 | 23 | 13 | 8,262 | 68 | 8.83 | 2.52 | 3.51 | 0.98 | 24.1 | 6.9 | 1.13 | .276 | 3.43 | 7.67 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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