Between August 9, 1989 and September 20, 2012, Randy Johnson struck out the most hitters, with 4,761 strikeouts.
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | R. Johnson | 4,761 | 594 | 295 | 159 | .650 | 580 | 3.27 | 97 | 37 | 2 | 3997.0 | 3,224 | 1,451 | 1,630 | 401 | 1,419 | 188 | 6 | 35 | 16,460 | 101 | 10.72 | 3.20 | 3.36 | 0.90 | 28.9 | 8.6 | 1.16 | .291 | 3.67 | 7.26 |
| 2 |  | R. Clemens | 3,537 | 545 | 265 | 142 | .651 | 544 | 3.14 | 62 | 25 | 0 | 3717.0 | 3,171 | 1,295 | 1,442 | 273 | 1,238 | 129 | 0 | 48 | 15,350 | 116 | 8.56 | 3.00 | 2.86 | 0.66 | 23.0 | 8.1 | 1.19 | .285 | 3.49 | 7.68 |
| 3 |  | P. Martinez | 3,154 | 476 | 219 | 100 | .687 | 409 | 2.93 | 46 | 17 | 3 | 2827.1 | 2,221 | 919 | 1,006 | 239 | 760 | 141 | 23 | 30 | 11,394 | 62 | 10.04 | 2.42 | 4.15 | 0.76 | 27.7 | 6.7 | 1.05 | .279 | 3.20 | 7.07 |
| 4 |  | C. Schilling | 3,112 | 565 | 216 | 143 | .602 | 432 | 3.43 | 83 | 20 | 22 | 3246.1 | 2,976 | 1,237 | 1,299 | 344 | 701 | 51 | 81 | 42 | 13,208 | 70 | 8.63 | 1.94 | 4.44 | 0.95 | 23.6 | 5.3 | 1.13 | .292 | 3.60 | 8.25 |
| 5 |  | G. Maddux | 3,025 | 650 | 316 | 193 | .621 | 650 | 3.06 | 93 | 30 | 0 | 4410.2 | 4,127 | 1,502 | 1,696 | 312 | 767 | 120 | 0 | 135 | 17,843 | 57 | 6.17 | 1.57 | 3.94 | 0.64 | 17.0 | 4.3 | 1.11 | .280 | 3.46 | 8.42 |
| 6 |  | J. Smoltz | 2,905 | 687 | 200 | 138 | .592 | 445 | 3.32 | 48 | 16 | 154 | 3234.1 | 2,868 | 1,194 | 1,293 | 266 | 919 | 54 | 204 | 80 | 13,269 | 138 | 8.08 | 2.56 | 3.16 | 0.74 | 21.9 | 6.9 | 1.17 | .285 | 3.60 | 7.98 |
| 7 | | M. Mussina | 2,813 | 537 | 270 | 153 | .638 | 536 | 3.68 | 57 | 23 | 0 | 3562.2 | 3,460 | 1,458 | 1,559 | 376 | 785 | 60 | 0 | 29 | 14,593 | 71 | 7.11 | 1.98 | 3.58 | 0.95 | 19.3 | 5.4 | 1.19 | .292 | 3.94 | 8.74 |
| 8 | | J. Vazquez | 2,536 | 450 | 165 | 160 | .508 | 443 | 4.22 | 28 | 8 | 0 | 2840.0 | 2,784 | 1,331 | 1,431 | 373 | 763 | 88 | 5 | 58 | 11,935 | 76 | 8.04 | 2.42 | 3.32 | 1.18 | 21.2 | 6.4 | 1.25 | .295 | 4.53 | 8.82 |
| 9 | | T. Glavine | 2,432 | 617 | 286 | 176 | .619 | 617 | 3.47 | 49 | 21 | 0 | 4026.2 | 3,910 | 1,551 | 1,695 | 323 | 1,379 | 54 | 0 | 132 | 16,945 | 60 | 5.44 | 3.08 | 1.76 | 0.72 | 14.4 | 8.1 | 1.31 | .281 | 3.79 | 8.74 |
| 10 | | A. Pettitte | 2,313 | 499 | 244 | 141 | .634 | 489 | 3.86 | 25 | 4 | 0 | 3119.0 | 3,238 | 1,338 | 1,484 | 270 | 979 | 51 | 3 | 41 | 13,242 | 63 | 6.67 | 2.82 | 2.36 | 0.78 | 17.5 | 7.4 | 1.35 | .308 | 4.28 | 9.34 |
| 11 | | K. Brown | 2,297 | 459 | 199 | 137 | .592 | 449 | 3.29 | 64 | 17 | 0 | 3065.2 | 2,916 | 1,120 | 1,280 | 196 | 837 | 136 | 1 | 40 | 12,754 | 101 | 6.74 | 2.46 | 2.74 | 0.58 | 18.0 | 6.6 | 1.22 | .293 | 3.76 | 8.56 |
| 12 | | C. Finley | 2,275 | 411 | 173 | 143 | .547 | 411 | 3.88 | 52 | 14 | 0 | 2706.1 | 2,599 | 1,168 | 1,301 | 271 | 1,127 | 65 | 0 | 25 | 11,548 | 117 | 7.57 | 3.75 | 2.02 | 0.90 | 19.7 | 9.8 | 1.38 | .298 | 4.33 | 8.64 |
| 13 | | D. Cone | 2,246 | 359 | 160 | 112 | .588 | 355 | 3.53 | 42 | 17 | 0 | 2396.0 | 2,083 | 941 | 1,028 | 220 | 947 | 93 | 1 | 29 | 10,102 | 126 | 8.44 | 3.56 | 2.37 | 0.83 | 22.2 | 9.4 | 1.26 | .282 | 3.86 | 7.82 |
| 14 |  | CC Sabathia | 2,186 | 380 | 189 | 102 | .649 | 380 | 3.52 | 35 | 12 | 0 | 2540.1 | 2,348 | 994 | 1,091 | 226 | 765 | 80 | 0 | 34 | 10,532 | 49 | 7.74 | 2.71 | 2.86 | 0.80 | 20.8 | 7.3 | 1.23 | .292 | 3.87 | 8.32 |
| 15 | | T. Wakefield | 2,156 | 627 | 200 | 180 | .526 | 463 | 4.41 | 33 | 6 | 22 | 3226.1 | 3,152 | 1,582 | 1,791 | 418 | 1,205 | 186 | 78 | 33 | 13,939 | 134 | 6.01 | 3.36 | 1.79 | 1.17 | 15.5 | 8.6 | 1.35 | .274 | 5.00 | 8.79 |
| 16 | | J. Moyer | 2,091 | 601 | 238 | 170 | .583 | 549 | 4.23 | 28 | 8 | 0 | 3530.1 | 3,649 | 1,659 | 1,784 | 459 | 935 | 132 | 13 | 52 | 14,973 | 38 | 5.33 | 2.38 | 2.24 | 1.17 | 14.0 | 6.2 | 1.30 | .281 | 4.55 | 9.30 |
| 17 | | K. Millwood | 2,083 | 451 | 169 | 152 | .526 | 443 | 4.11 | 22 | 6 | 0 | 2720.1 | 2,770 | 1,243 | 1,357 | 296 | 843 | 74 | 3 | 46 | 11,616 | 67 | 6.89 | 2.79 | 2.47 | 0.98 | 17.9 | 7.3 | 1.33 | .297 | 4.49 | 9.16 |
| 18 | | R. Halladay | 2,056 | 401 | 198 | 99 | .667 | 375 | 3.28 | 66 | 20 | 1 | 2680.2 | 2,580 | 976 | 1,076 | 222 | 550 | 71 | 6 | 27 | 10,969 | 52 | 6.90 | 1.85 | 3.74 | 0.75 | 18.7 | 5.0 | 1.17 | .292 | 3.61 | 8.66 |
| 19 | | D. Wells | 2,048 | 564 | 227 | 145 | .610 | 487 | 4.15 | 54 | 12 | 6 | 3279.1 | 3,483 | 1,512 | 1,630 | 391 | 657 | 81 | 32 | 51 | 13,736 | 88 | 5.62 | 1.80 | 3.12 | 1.07 | 14.9 | 4.8 | 1.26 | .293 | 4.47 | 9.56 |
| 20 | | A. Benes | 2,000 | 403 | 155 | 139 | .527 | 387 | 3.97 | 21 | 9 | 1 | 2505.1 | 2,377 | 1,106 | 1,206 | 289 | 909 | 55 | 6 | 52 | 10,645 | 63 | 7.18 | 3.27 | 2.20 | 1.04 | 18.8 | 8.5 | 1.31 | .282 | 4.33 | 8.54 |
| 21 | | J. Santana | 1,988 | 360 | 139 | 78 | .641 | 284 | 3.20 | 15 | 10 | 1 | 2025.2 | 1,726 | 721 | 773 | 220 | 567 | 36 | 23 | 13 | 8,262 | 68 | 8.83 | 2.52 | 3.51 | 0.98 | 24.1 | 6.9 | 1.13 | .276 | 3.43 | 7.67 |
| 22 | | K. Appier | 1,984 | 408 | 168 | 133 | .558 | 397 | 3.69 | 34 | 12 | 0 | 2573.2 | 2,391 | 1,056 | 1,146 | 229 | 921 | 79 | 2 | 50 | 10,852 | 106 | 6.94 | 3.22 | 2.15 | 0.80 | 18.3 | 8.5 | 1.29 | .283 | 4.01 | 8.36 |
| 23 | | L. Hernandez | 1,976 | 517 | 178 | 177 | .501 | 474 | 4.41 | 50 | 9 | 1 | 3187.2 | 3,515 | 1,561 | 1,675 | 357 | 1,065 | 78 | 17 | 86 | 13,801 | 40 | 5.58 | 3.01 | 1.86 | 1.01 | 14.3 | 7.7 | 1.44 | .306 | 4.73 | 9.92 |
| 24 | | A.J. Burnett | 1,952 | 342 | 136 | 119 | .533 | 337 | 4.06 | 22 | 10 | 0 | 2141.0 | 1,956 | 967 | 1,057 | 220 | 884 | 106 | 1 | 28 | 9,147 | 133 | 8.21 | 3.72 | 2.21 | 0.92 | 21.3 | 9.7 | 1.33 | .290 | 4.44 | 8.22 |
| 25 | | K. Rogers | 1,922 | 713 | 217 | 156 | .582 | 474 | 4.29 | 36 | 9 | 27 | 3253.2 | 3,414 | 1,552 | 1,719 | 338 | 1,143 | 123 | 117 | 46 | 14,062 | 75 | 5.32 | 3.16 | 1.68 | 0.93 | 13.7 | 8.1 | 1.40 | .292 | 4.75 | 9.44 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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 Braves - y | 94 | 68 | .580 | |
 Phillies - w | 88 | 74 | .543 | 6.0 |
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| NL Central | W | L | PCT | GB |
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 Astros - y | 81 | 81 | .500 | |
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