Between July 1, 1987 and June 20, 2013, Randy Johnson fanned the most hitters, with 4,875 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | R. Johnson | 4,875 | 618 | 303 | 166 | .646 | 603 | 3.29 | 100 | 37 | 2 | 4135.1 | 3,346 | 1,513 | 1,703 | 411 | 1,497 | 190 | 7 | 37 | 17,067 | 109 | 10.61 | 3.26 | 3.26 | 0.89 | 28.6 | 8.8 | 1.17 | .291 | 3.71 | 7.28 |
| 2 |  | R. Clemens | 4,128 | 624 | 308 | 165 | .651 | 623 | 3.11 | 93 | 40 | 0 | 4310.2 | 3,670 | 1,488 | 1,651 | 314 | 1,403 | 144 | 0 | 56 | 17,759 | 124 | 8.62 | 2.93 | 2.94 | 0.66 | 23.2 | 7.9 | 1.18 | .285 | 3.45 | 7.66 |
| 3 |  | G. Maddux | 3,290 | 722 | 349 | 216 | .618 | 720 | 3.11 | 108 | 35 | 0 | 4885.0 | 4,582 | 1,687 | 1,908 | 339 | 947 | 133 | 2 | 169 | 19,871 | 65 | 6.06 | 1.74 | 3.47 | 0.62 | 16.6 | 4.8 | 1.13 | .280 | 3.52 | 8.44 |
| 4 |  | P. Martinez | 3,154 | 476 | 219 | 100 | .687 | 409 | 2.93 | 46 | 17 | 3 | 2827.1 | 2,221 | 919 | 1,006 | 239 | 760 | 141 | 23 | 30 | 11,394 | 62 | 10.04 | 2.42 | 4.15 | 0.76 | 27.7 | 6.7 | 1.05 | .279 | 3.20 | 7.07 |
| 5 |  | C. Schilling | 3,116 | 569 | 216 | 146 | .597 | 436 | 3.46 | 83 | 20 | 22 | 3261.0 | 2,998 | 1,253 | 1,318 | 347 | 711 | 52 | 81 | 43 | 13,284 | 72 | 8.60 | 1.96 | 4.38 | 0.96 | 23.5 | 5.4 | 1.14 | .293 | 3.64 | 8.27 |
| 6 |  | J. Smoltz | 3,084 | 723 | 213 | 155 | .579 | 481 | 3.33 | 53 | 16 | 154 | 3473.0 | 3,074 | 1,284 | 1,391 | 288 | 1,010 | 57 | 204 | 84 | 14,271 | 145 | 7.99 | 2.62 | 3.05 | 0.75 | 21.6 | 7.1 | 1.18 | .283 | 3.60 | 7.97 |
| 7 | | M. Mussina | 2,813 | 537 | 270 | 153 | .638 | 536 | 3.68 | 57 | 23 | 0 | 3562.2 | 3,460 | 1,458 | 1,559 | 376 | 785 | 60 | 0 | 29 | 14,593 | 71 | 7.11 | 1.98 | 3.58 | 0.95 | 19.3 | 5.4 | 1.19 | .292 | 3.94 | 8.74 |
| 8 | | D. Cone | 2,617 | 429 | 192 | 124 | .608 | 413 | 3.43 | 55 | 22 | 1 | 2829.0 | 2,428 | 1,078 | 1,180 | 250 | 1,097 | 105 | 3 | 40 | 11,868 | 144 | 8.33 | 3.49 | 2.39 | 0.80 | 22.1 | 9.2 | 1.25 | .279 | 3.75 | 7.72 |
| 9 | | T. Glavine | 2,607 | 682 | 305 | 203 | .600 | 682 | 3.54 | 56 | 25 | 0 | 4413.1 | 4,298 | 1,734 | 1,900 | 356 | 1,500 | 66 | 0 | 145 | 18,604 | 65 | 5.32 | 3.06 | 1.74 | 0.73 | 14.0 | 8.1 | 1.31 | .280 | 3.87 | 8.76 |
| 10 | | C. Finley | 2,544 | 483 | 197 | 169 | .538 | 467 | 3.84 | 63 | 15 | 0 | 3118.0 | 2,988 | 1,331 | 1,478 | 301 | 1,287 | 75 | 9 | 33 | 13,282 | 125 | 7.34 | 3.71 | 1.98 | 0.87 | 19.2 | 9.7 | 1.37 | .296 | 4.27 | 8.62 |
| 11 | | J. Vazquez | 2,536 | 450 | 165 | 160 | .508 | 443 | 4.22 | 28 | 8 | 0 | 2840.0 | 2,784 | 1,331 | 1,431 | 373 | 763 | 88 | 5 | 58 | 11,935 | 76 | 8.04 | 2.42 | 3.32 | 1.18 | 21.2 | 6.4 | 1.25 | .295 | 4.53 | 8.82 |
| 12 | | K. Brown | 2,393 | 485 | 210 | 144 | .593 | 475 | 3.27 | 72 | 17 | 0 | 3251.1 | 3,073 | 1,183 | 1,355 | 208 | 901 | 139 | 1 | 42 | 13,523 | 108 | 6.62 | 2.49 | 2.66 | 0.58 | 17.7 | 6.7 | 1.22 | .290 | 3.75 | 8.51 |
| 13 | | A. Pettitte | 2,378 | 513 | 250 | 147 | .630 | 503 | 3.86 | 25 | 4 | 0 | 3205.2 | 3,329 | 1,376 | 1,524 | 278 | 1,003 | 54 | 3 | 42 | 13,608 | 68 | 6.68 | 2.82 | 2.37 | 0.78 | 17.5 | 7.4 | 1.35 | .308 | 4.28 | 9.35 |
| 14 | | J. Moyer | 2,324 | 663 | 254 | 200 | .559 | 607 | 4.24 | 31 | 9 | 0 | 3886.0 | 4,034 | 1,831 | 1,976 | 501 | 1,062 | 140 | 14 | 65 | 16,526 | 47 | 5.38 | 2.46 | 2.19 | 1.16 | 14.1 | 6.4 | 1.31 | .283 | 4.58 | 9.34 |
| 15 |  | CC Sabathia | 2,303 | 398 | 198 | 107 | .649 | 398 | 3.52 | 36 | 12 | 0 | 2667.1 | 2,467 | 1,043 | 1,143 | 241 | 790 | 83 | 0 | 35 | 11,050 | 52 | 7.77 | 2.67 | 2.92 | 0.81 | 20.8 | 7.1 | 1.22 | .292 | 3.86 | 8.32 |
| 16 | | D. Wells | 2,197 | 659 | 239 | 156 | .605 | 488 | 4.12 | 54 | 12 | 13 | 3435.0 | 3,626 | 1,574 | 1,698 | 407 | 717 | 83 | 65 | 65 | 14,391 | 98 | 5.76 | 1.88 | 3.06 | 1.07 | 15.3 | 5.0 | 1.26 | .293 | 4.45 | 9.50 |
| 17 | | T. Wakefield | 2,156 | 627 | 200 | 180 | .526 | 463 | 4.41 | 33 | 6 | 22 | 3226.1 | 3,152 | 1,582 | 1,791 | 418 | 1,205 | 186 | 78 | 33 | 13,939 | 134 | 6.01 | 3.36 | 1.79 | 1.17 | 15.5 | 8.6 | 1.35 | .274 | 5.00 | 8.79 |
| 18 | | R. Halladay | 2,101 | 410 | 201 | 104 | .659 | 384 | 3.37 | 67 | 20 | 1 | 2721.2 | 2,624 | 1,020 | 1,120 | 233 | 573 | 75 | 6 | 27 | 11,160 | 54 | 6.95 | 1.89 | 3.67 | 0.77 | 18.8 | 5.1 | 1.17 | .292 | 3.70 | 8.68 |
| 19 | | K. Millwood | 2,083 | 451 | 169 | 152 | .526 | 443 | 4.11 | 22 | 6 | 0 | 2720.1 | 2,770 | 1,243 | 1,357 | 296 | 843 | 74 | 3 | 46 | 11,616 | 67 | 6.89 | 2.79 | 2.47 | 0.98 | 17.9 | 7.3 | 1.33 | .297 | 4.49 | 9.16 |
| 20 | | A.J. Burnett | 2,070 | 359 | 141 | 127 | .526 | 354 | 4.01 | 22 | 10 | 0 | 2252.0 | 2,041 | 1,004 | 1,095 | 229 | 923 | 111 | 1 | 29 | 9,596 | 140 | 8.27 | 3.69 | 2.24 | 0.92 | 21.6 | 9.6 | 1.32 | .289 | 4.38 | 8.16 |
| 21 | | R. Dempster | 2,008 | 562 | 128 | 132 | .492 | 337 | 4.33 | 11 | 3 | 87 | 2305.0 | 2,256 | 1,109 | 1,199 | 257 | 1,034 | 87 | 185 | 47 | 10,043 | 76 | 7.84 | 4.04 | 1.94 | 1.00 | 20.0 | 10.3 | 1.43 | .300 | 4.68 | 8.81 |
| 22 | | A. Benes | 2,000 | 403 | 155 | 139 | .527 | 387 | 3.97 | 21 | 9 | 1 | 2505.1 | 2,377 | 1,106 | 1,206 | 289 | 909 | 55 | 6 | 52 | 10,645 | 63 | 7.18 | 3.27 | 2.20 | 1.04 | 18.8 | 8.5 | 1.31 | .282 | 4.33 | 8.54 |
| 23 | | K. Appier | 1,994 | 414 | 169 | 137 | .552 | 402 | 3.74 | 34 | 12 | 0 | 2595.1 | 2,425 | 1,078 | 1,168 | 232 | 933 | 79 | 2 | 51 | 10,958 | 106 | 6.91 | 3.24 | 2.14 | 0.80 | 18.2 | 8.5 | 1.29 | .284 | 4.05 | 8.41 |
| 24 | | J. Santana | 1,988 | 360 | 139 | 78 | .641 | 284 | 3.20 | 15 | 10 | 1 | 2025.2 | 1,726 | 721 | 773 | 220 | 567 | 36 | 23 | 13 | 8,262 | 68 | 8.83 | 2.52 | 3.51 | 0.98 | 24.1 | 6.9 | 1.13 | .276 | 3.43 | 7.67 |
| 25 | | L. Hernandez | 1,976 | 519 | 178 | 177 | .501 | 474 | 4.44 | 50 | 9 | 1 | 3189.0 | 3,525 | 1,572 | 1,686 | 362 | 1,066 | 78 | 17 | 86 | 13,816 | 41 | 5.58 | 3.01 | 1.85 | 1.02 | 14.3 | 7.7 | 1.44 | .306 | 4.76 | 9.95 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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