Between July 20, 1924 and September 28, 1947, Lefty Grove struck out the most hitters, with 2,269 strikeouts.
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | L. Grove | 2,269 | 616 | 300 | 141 | .680 | 457 | 3.06 | 298 | 35 | 54 | 3938.1 | 3,848 | 1,341 | 1,596 | 162 | 1,184 | 41 | 123 | 16,622 | 51 | 5.19 | 2.71 | 1.92 | 0.37 | 13.7 | 7.1 | 1.28 | .284 | 3.65 | 8.79 | |
| 2 | | B. Newsom | 2,030 | 548 | 205 | 213 | .490 | 472 | 3.97 | 244 | 31 | 18 | 3634.2 | 3,635 | 1,605 | 1,842 | 199 | 1,665 | 54 | 50 | 15,908 | 57 | 5.03 | 4.12 | 1.22 | 0.49 | 12.8 | 10.5 | 1.46 | .287 | 4.56 | 9.00 | |
| 3 | | R. Ruffing | 1,983 | 618 | 273 | 225 | .548 | 537 | 3.79 | 335 | 45 | 18 | 4328.1 | 4,269 | 1,823 | 2,105 | 254 | 1,538 | 56 | 66 | 18,467 | 45 | 4.12 | 3.20 | 1.29 | 0.53 | 10.7 | 8.3 | 1.34 | .274 | 4.38 | 8.88 | |
| 4 | | B. Feller | 1,836 | 304 | 158 | 83 | .656 | 263 | 2.92 | 180 | 32 | 17 | 2190.2 | 1,706 | 711 | 788 | 87 | 1,130 | 35 | 33 | 9,217 | 57 | 7.54 | 4.64 | 1.62 | 0.36 | 19.9 | 12.3 | 1.29 | .264 | 3.24 | 7.01 | |
| 5 | | T. Bridges | 1,681 | 424 | 194 | 138 | .584 | 362 | 3.57 | 200 | 33 | 10 | 2825.2 | 2,674 | 1,122 | 1,322 | 179 | 1,193 | 35 | 47 | 12,163 | 59 | 5.35 | 3.80 | 1.41 | 0.57 | 13.8 | 9.8 | 1.37 | .275 | 4.21 | 8.52 | |
| 6 | | C. Hubbell | 1,678 | 535 | 253 | 154 | .622 | 433 | 2.98 | 260 | 36 | 33 | 3588.2 | 3,462 | 1,188 | 1,384 | 227 | 728 | 53 | 82 | 14,810 | 53 | 4.21 | 1.83 | 2.30 | 0.57 | 11.3 | 4.9 | 1.17 | .267 | 3.47 | 8.68 | |
| 7 | | D. Vance | 1,573 | 340 | 147 | 105 | .583 | 261 | 3.21 | 162 | 21 | 12 | 2243.1 | 2,103 | 799 | 925 | 108 | 583 | 53 | 42 | 9,291 | 24 | 6.31 | 2.34 | 2.70 | 0.43 | 16.9 | 6.3 | 1.20 | .286 | 3.71 | 8.44 | |
| 8 | | P. Derringer | 1,509 | 579 | 223 | 212 | .513 | 445 | 3.46 | 251 | 32 | 29 | 3643.0 | 3,911 | 1,401 | 1,653 | 159 | 765 | 32 | 98 | 15,404 | 50 | 3.73 | 1.89 | 1.97 | 0.39 | 9.8 | 5.0 | 1.28 | .290 | 4.08 | 9.66 | |
| 9 | | L. Gomez | 1,468 | 368 | 189 | 102 | .649 | 320 | 3.34 | 173 | 28 | 10 | 2502.0 | 2,289 | 929 | 1,090 | 139 | 1,095 | 21 | 31 | 10,712 | 39 | 5.28 | 3.94 | 1.34 | 0.50 | 13.7 | 10.2 | 1.35 | .269 | 3.92 | 8.23 | |
| 10 | | C. Root | 1,435 | 605 | 201 | 156 | .563 | 339 | 3.55 | 177 | 21 | 42 | 3139.0 | 3,186 | 1,237 | 1,423 | 186 | 871 | 74 | 171 | 13,270 | 21 | 4.11 | 2.50 | 1.65 | 0.53 | 10.8 | 6.6 | 1.29 | .280 | 4.08 | 9.13 | |
| 11 | | B. Hadley | 1,316 | 528 | 161 | 165 | .494 | 355 | 4.24 | 134 | 14 | 25 | 2945.0 | 2,978 | 1,389 | 1,610 | 167 | 1,446 | 63 | 108 | 13,012 | 72 | 4.02 | 4.42 | 0.91 | 0.51 | 10.1 | 11.1 | 1.50 | .281 | 4.92 | 9.10 | |
| 12 | | E. Whitehill | 1,302 | 515 | 206 | 182 | .531 | 454 | 4.42 | 215 | 14 | 11 | 3413.2 | 3,769 | 1,675 | 1,952 | 185 | 1,378 | 90 | 43 | 15,128 | 42 | 3.43 | 3.63 | 0.94 | 0.49 | 8.6 | 9.1 | 1.51 | .294 | 5.15 | 9.94 | |
| 13 | | H. Newhouser | 1,296 | 301 | 131 | 96 | .577 | 236 | 2.74 | 141 | 26 | 13 | 1894.0 | 1,605 | 577 | 703 | 56 | 860 | 9 | 49 | 8,001 | 47 | 6.16 | 4.09 | 1.51 | 0.27 | 16.2 | 10.7 | 1.30 | .268 | 3.34 | 7.63 | |
| 14 | | V. Mungo | 1,245 | 364 | 120 | 115 | .511 | 259 | 3.48 | 123 | 20 | 16 | 2110.2 | 1,954 | 815 | 958 | 89 | 874 | 33 | 61 | 9,031 | 52 | 5.31 | 3.73 | 1.42 | 0.38 | 13.8 | 9.7 | 1.34 | .275 | 4.08 | 8.33 | |
| 15 | | L. French | 1,186 | 570 | 197 | 171 | .535 | 383 | 3.45 | 199 | 40 | 17 | 3150.1 | 3,372 | 1,207 | 1,441 | 163 | 822 | 42 | 108 | 13,458 | 34 | 3.39 | 2.35 | 1.44 | 0.47 | 8.8 | 6.1 | 1.33 | .285 | 4.12 | 9.63 | |
| 16 | | D. Dean | 1,163 | 317 | 150 | 83 | .644 | 230 | 3.02 | 154 | 26 | 31 | 1968.2 | 1,920 | 661 | 774 | 93 | 451 | 27 | 77 | 8,176 | 12 | 5.32 | 2.06 | 2.58 | 0.43 | 14.2 | 5.5 | 1.20 | .284 | 3.54 | 8.78 | |
| 17 | | M. Harder | 1,162 | 582 | 223 | 186 | .545 | 433 | 3.80 | 181 | 25 | 24 | 3425.1 | 3,706 | 1,447 | 1,714 | 159 | 1,118 | 59 | 94 | 14,862 | 33 | 3.05 | 2.94 | 1.04 | 0.42 | 7.8 | 7.5 | 1.41 | .287 | 4.50 | 9.74 | |
| 18 | | L. Warneke | 1,145 | 445 | 192 | 121 | .613 | 343 | 3.19 | 192 | 30 | 14 | 2780.2 | 2,729 | 987 | 1,167 | 174 | 740 | 27 | 66 | 11,610 | 50 | 3.71 | 2.40 | 1.55 | 0.56 | 9.9 | 6.4 | 1.25 | .268 | 3.78 | 8.83 | |
| 19 | | C. Passeau | 1,104 | 444 | 162 | 150 | .519 | 331 | 3.32 | 188 | 26 | 21 | 2719.0 | 2,856 | 1,003 | 1,203 | 106 | 731 | 40 | 85 | 11,645 | 22 | 3.65 | 2.42 | 1.51 | 0.35 | 9.5 | 6.3 | 1.32 | .285 | 3.98 | 9.45 | |
| 20 | | B. Walters | 1,092 | 420 | 198 | 157 | .558 | 393 | 3.29 | 241 | 42 | 4 | 3064.2 | 2,944 | 1,119 | 1,317 | 146 | 1,102 | 52 | 17 | 12,974 | 61 | 3.21 | 3.24 | 0.99 | 0.43 | 8.4 | 8.5 | 1.32 | .264 | 3.87 | 8.65 | |
| 21 | | J. Allen | 1,072 | 352 | 142 | 75 | .654 | 241 | 3.76 | 109 | 17 | 16 | 1950.1 | 1,850 | 814 | 927 | 103 | 738 | 38 | 68 | 8,296 | 68 | 4.95 | 3.41 | 1.45 | 0.48 | 12.9 | 8.9 | 1.33 | .275 | 4.28 | 8.54 | |
| 22 | | J. Vander Meer | 1,064 | 252 | 94 | 92 | .505 | 222 | 3.26 | 110 | 23 | 1 | 1636.0 | 1,355 | 593 | 674 | 62 | 863 | 18 | 9 | 6,987 | 27 | 5.85 | 4.75 | 1.23 | 0.34 | 15.2 | 12.4 | 1.36 | .260 | 3.71 | 7.45 | |
| 23 | | R. Walberg | 1,044 | 510 | 151 | 133 | .532 | 294 | 4.09 | 135 | 15 | 34 | 2517.0 | 2,653 | 1,145 | 1,336 | 154 | 958 | 25 | 134 | 10,958 | 38 | 3.73 | 3.43 | 1.09 | 0.55 | 9.5 | 8.7 | 1.43 | .285 | 4.78 | 9.49 | |
| 24 | | P. Malone | 1,033 | 357 | 134 | 92 | .593 | 219 | 3.73 | 114 | 15 | 27 | 1915.0 | 1,933 | 794 | 935 | 103 | 696 | 46 | 107 | 8,275 | 51 | 4.85 | 3.27 | 1.48 | 0.48 | 12.5 | 8.4 | 1.37 | .286 | 4.39 | 9.08 | |
| 25 | | T. Lyons | 1,033 | 561 | 250 | 219 | .533 | 465 | 3.63 | 347 | 27 | 22 | 3988.1 | 4,282 | 1,609 | 1,949 | 212 | 1,062 | 28 | 83 | 17,042 | 49 | 2.33 | 2.40 | 0.97 | 0.48 | 6.1 | 6.2 | 1.34 | .277 | 4.40 | 9.66 | |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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