Between July 21, 1993 and September 20, 2014, Randy Johnson struck out the most hitters, with 3,878 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | R. Johnson | 3,878 | 468 | 244 | 113 | .683 | 454 | 3.12 | 78 | 30 | 2 | 3166.2 | 2,586 | 1,099 | 1,234 | 327 | 917 | 141 | 6 | 31 | 12,876 | 65 | 11.02 | 2.61 | 4.23 | 0.93 | 30.1 | 7.1 | 1.11 | .297 | 3.51 | 7.35 |
| 2 |  | P. Martinez | 3,081 | 436 | 212 | 97 | .686 | 408 | 2.94 | 46 | 17 | 1 | 2757.2 | 2,175 | 901 | 987 | 236 | 723 | 140 | 13 | 26 | 11,105 | 62 | 10.06 | 2.36 | 4.26 | 0.77 | 27.7 | 6.5 | 1.05 | .280 | 3.22 | 7.10 |
| 3 |  | C. Schilling | 2,768 | 407 | 189 | 118 | .616 | 385 | 3.46 | 68 | 14 | 9 | 2755.0 | 2,547 | 1,060 | 1,106 | 313 | 547 | 47 | 21 | 28 | 11,182 | 59 | 9.04 | 1.79 | 5.06 | 1.02 | 24.8 | 4.9 | 1.12 | .298 | 3.61 | 8.32 |
| 4 |  | R. Clemens | 2,695 | 420 | 194 | 106 | .647 | 419 | 3.35 | 27 | 11 | 0 | 2775.2 | 2,390 | 1,033 | 1,132 | 226 | 994 | 101 | 0 | 25 | 11,560 | 95 | 8.74 | 3.22 | 2.71 | 0.73 | 23.3 | 8.6 | 1.22 | .287 | 3.67 | 7.75 |
| 5 | | M. Mussina | 2,546 | 475 | 237 | 139 | .630 | 474 | 3.77 | 44 | 17 | 0 | 3111.2 | 3,054 | 1,303 | 1,398 | 338 | 685 | 54 | 0 | 26 | 12,783 | 58 | 7.36 | 1.98 | 3.72 | 0.98 | 19.9 | 5.4 | 1.20 | .297 | 4.04 | 8.83 |
| 6 | | J. Vazquez | 2,536 | 450 | 165 | 160 | .508 | 443 | 4.22 | 28 | 8 | 0 | 2840.0 | 2,784 | 1,331 | 1,431 | 373 | 763 | 88 | 5 | 58 | 11,935 | 76 | 8.04 | 2.42 | 3.32 | 1.18 | 21.2 | 6.4 | 1.25 | .295 | 4.53 | 8.82 |
| 7 | | A. Pettitte | 2,448 | 531 | 256 | 153 | .626 | 521 | 3.85 | 26 | 4 | 0 | 3316.0 | 3,448 | 1,418 | 1,572 | 288 | 1,031 | 55 | 3 | 42 | 14,074 | 69 | 6.64 | 2.80 | 2.37 | 0.78 | 17.4 | 7.3 | 1.35 | .308 | 4.27 | 9.36 |
| 8 |  | CC Sabathia | 2,437 | 423 | 208 | 119 | .636 | 423 | 3.63 | 37 | 12 | 0 | 2821.1 | 2,643 | 1,137 | 1,248 | 265 | 844 | 89 | 0 | 39 | 11,739 | 59 | 7.77 | 2.69 | 2.89 | 0.85 | 20.8 | 7.2 | 1.24 | .293 | 3.98 | 8.43 |
| 9 | | A.J. Burnett | 2,360 | 407 | 155 | 149 | .510 | 402 | 4.02 | 24 | 10 | 0 | 2556.1 | 2,337 | 1,142 | 1,254 | 250 | 1,042 | 130 | 1 | 33 | 10,916 | 155 | 8.31 | 3.67 | 2.26 | 0.88 | 21.6 | 9.5 | 1.32 | .293 | 4.41 | 8.23 |
| 10 |  | G. Maddux | 2,314 | 511 | 251 | 144 | .635 | 511 | 3.09 | 63 | 22 | 0 | 3413.0 | 3,238 | 1,172 | 1,310 | 261 | 511 | 89 | 0 | 102 | 13,767 | 40 | 6.10 | 1.35 | 4.53 | 0.69 | 16.8 | 3.7 | 1.10 | .281 | 3.45 | 8.54 |
| 11 |  | J. Smoltz | 2,222 | 557 | 148 | 93 | .614 | 315 | 3.26 | 25 | 10 | 154 | 2354.2 | 2,107 | 853 | 919 | 200 | 597 | 40 | 204 | 62 | 9,610 | 80 | 8.49 | 2.28 | 3.72 | 0.76 | 23.1 | 6.2 | 1.15 | .291 | 3.51 | 8.05 |
| 12 | | R. Halladay | 2,117 | 416 | 203 | 105 | .659 | 390 | 3.38 | 67 | 20 | 1 | 2749.1 | 2,646 | 1,034 | 1,135 | 236 | 592 | 81 | 6 | 28 | 11,287 | 56 | 6.93 | 1.94 | 3.58 | 0.77 | 18.8 | 5.2 | 1.18 | .292 | 3.72 | 8.66 |
| 13 |  | B. Colon | 2,093 | 440 | 203 | 140 | .592 | 434 | 3.95 | 35 | 12 | 0 | 2774.0 | 2,799 | 1,217 | 1,328 | 329 | 827 | 53 | 0 | 38 | 11,721 | 41 | 6.79 | 2.68 | 2.53 | 1.07 | 17.9 | 7.1 | 1.31 | .293 | 4.31 | 9.08 |
| 14 | | K. Millwood | 2,083 | 451 | 169 | 152 | .526 | 443 | 4.11 | 22 | 6 | 0 | 2720.1 | 2,770 | 1,243 | 1,357 | 296 | 843 | 74 | 3 | 46 | 11,616 | 67 | 6.89 | 2.79 | 2.47 | 0.98 | 17.9 | 7.3 | 1.33 | .297 | 4.49 | 9.16 |
| 15 | | R. Dempster | 2,075 | 579 | 132 | 133 | .498 | 351 | 4.35 | 11 | 3 | 87 | 2387.0 | 2,347 | 1,154 | 1,250 | 267 | 1,071 | 91 | 186 | 47 | 10,412 | 80 | 7.82 | 4.04 | 1.94 | 1.01 | 19.9 | 10.3 | 1.43 | .301 | 4.71 | 8.85 |
| 16 | | T. Wakefield | 2,062 | 595 | 188 | 171 | .524 | 435 | 4.42 | 28 | 5 | 22 | 3039.1 | 2,964 | 1,493 | 1,697 | 403 | 1,109 | 179 | 77 | 30 | 13,117 | 129 | 6.11 | 3.28 | 1.86 | 1.19 | 15.7 | 8.5 | 1.34 | .273 | 5.03 | 8.78 |
| 17 | | J. Peavy | 2,020 | 336 | 139 | 111 | .556 | 335 | 3.54 | 15 | 6 | 0 | 2135.2 | 1,893 | 840 | 887 | 228 | 643 | 72 | 0 | 40 | 8,819 | 40 | 8.51 | 2.71 | 3.14 | 0.96 | 22.9 | 7.3 | 1.19 | .284 | 3.74 | 7.98 |
| 18 | | T. Hudson | 2,012 | 457 | 214 | 123 | .635 | 456 | 3.45 | 26 | 13 | 0 | 2997.2 | 2,818 | 1,149 | 1,254 | 234 | 879 | 116 | 0 | 83 | 12,458 | 80 | 6.04 | 2.64 | 2.29 | 0.70 | 16.2 | 7.1 | 1.23 | .280 | 3.76 | 8.46 |
| 19 | | J. Santana | 1,988 | 360 | 139 | 78 | .641 | 284 | 3.20 | 15 | 10 | 1 | 2025.2 | 1,726 | 721 | 773 | 220 | 567 | 36 | 23 | 13 | 8,262 | 68 | 8.83 | 2.52 | 3.51 | 0.98 | 24.1 | 6.9 | 1.13 | .276 | 3.43 | 7.67 |
| 20 | | L. Hernandez | 1,976 | 519 | 178 | 177 | .501 | 474 | 4.44 | 50 | 9 | 1 | 3189.0 | 3,525 | 1,572 | 1,686 | 362 | 1,066 | 78 | 17 | 86 | 13,816 | 41 | 5.58 | 3.01 | 1.85 | 1.02 | 14.3 | 7.7 | 1.44 | .306 | 4.76 | 9.95 |
| 21 | | J. Moyer | 1,973 | 543 | 229 | 151 | .603 | 515 | 4.21 | 25 | 7 | 0 | 3303.0 | 3,392 | 1,544 | 1,653 | 439 | 851 | 126 | 6 | 47 | 13,984 | 35 | 5.38 | 2.32 | 2.32 | 1.20 | 14.1 | 6.1 | 1.28 | .279 | 4.50 | 9.24 |
| 22 |  | F. Hernandez | 1,939 | 301 | 124 | 91 | .577 | 301 | 3.07 | 23 | 9 | 0 | 2050.2 | 1,832 | 700 | 782 | 160 | 569 | 62 | 0 | 16 | 8,384 | 115 | 8.51 | 2.50 | 3.41 | 0.70 | 23.1 | 6.8 | 1.17 | .296 | 3.43 | 8.04 |
| 23 | | H. Nomo | 1,918 | 323 | 123 | 109 | .530 | 318 | 4.24 | 16 | 9 | 0 | 1976.1 | 1,768 | 932 | 993 | 251 | 908 | 38 | 2 | 31 | 8,462 | 110 | 8.73 | 4.13 | 2.11 | 1.14 | 22.7 | 10.7 | 1.35 | .284 | 4.52 | 8.05 |
| 24 | | T. Glavine | 1,902 | 489 | 221 | 139 | .614 | 489 | 3.54 | 28 | 13 | 0 | 3154.0 | 3,108 | 1,240 | 1,341 | 271 | 1,090 | 47 | 0 | 103 | 13,319 | 34 | 5.43 | 3.11 | 1.74 | 0.77 | 14.3 | 8.2 | 1.33 | .283 | 3.83 | 8.87 |
| 25 | | J. Beckett | 1,901 | 335 | 138 | 106 | .566 | 332 | 3.88 | 12 | 6 | 0 | 2051.0 | 1,897 | 884 | 957 | 238 | 629 | 76 | 1 | 28 | 8,579 | 59 | 8.34 | 2.76 | 3.02 | 1.04 | 22.2 | 7.3 | 1.23 | .289 | 4.20 | 8.32 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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