Between July 21, 1995 and May 29, 2017, Randy Johnson struck out the most batters, with 3,369 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | R. Johnson | 3,369 | 412 | 212 | 103 | .673 | 399 | 3.14 | 61 | 23 | 1 | 2764.2 | 2,281 | 964 | 1,090 | 299 | 769 | 125 | 5 | 28 | 11,238 | 56 | 10.97 | 2.50 | 4.38 | 0.97 | 30.0 | 6.8 | 1.10 | .297 | 3.55 | 7.43 |
| 2 |  | P. Martinez | 2,786 | 368 | 190 | 84 | .693 | 366 | 2.92 | 44 | 15 | 0 | 2456.2 | 1,941 | 796 | 876 | 213 | 621 | 120 | 1 | 22 | 9,895 | 49 | 10.21 | 2.28 | 4.49 | 0.78 | 28.2 | 6.3 | 1.04 | .281 | 3.21 | 7.11 |
| 3 |  | CC Sabathia | 2,772 | 492 | 228 | 143 | .615 | 492 | 3.71 | 38 | 12 | 0 | 3225.1 | 3,060 | 1,331 | 1,453 | 323 | 982 | 107 | 0 | 43 | 13,482 | 67 | 7.74 | 2.74 | 2.82 | 0.90 | 20.6 | 7.3 | 1.25 | .294 | 4.05 | 8.54 |
| 4 |  | J. Vazquez | 2,536 | 450 | 165 | 160 | .508 | 443 | 4.22 | 28 | 8 | 0 | 2840.0 | 2,784 | 1,331 | 1,431 | 373 | 763 | 88 | 5 | 58 | 11,935 | 76 | 8.04 | 2.42 | 3.32 | 1.18 | 21.2 | 6.4 | 1.25 | .295 | 4.53 | 8.82 |
| 5 | | A.J. Burnett | 2,513 | 435 | 164 | 157 | .511 | 430 | 3.99 | 24 | 10 | 0 | 2731.1 | 2,519 | 1,210 | 1,328 | 263 | 1,100 | 143 | 1 | 35 | 11,665 | 161 | 8.28 | 3.62 | 2.28 | 0.87 | 21.5 | 9.4 | 1.32 | .295 | 4.38 | 8.30 |
| 6 | | C. Schilling | 2,498 | 363 | 173 | 104 | .625 | 341 | 3.43 | 64 | 14 | 9 | 2456.0 | 2,267 | 935 | 970 | 283 | 470 | 40 | 21 | 20 | 9,933 | 49 | 9.15 | 1.72 | 5.31 | 1.04 | 25.1 | 4.7 | 1.11 | .299 | 3.55 | 8.31 |
| 7 |  | R. Clemens | 2,416 | 373 | 179 | 89 | .668 | 372 | 3.27 | 24 | 10 | 0 | 2462.2 | 2,123 | 895 | 983 | 193 | 865 | 82 | 0 | 22 | 10,238 | 82 | 8.83 | 3.16 | 2.79 | 0.71 | 23.6 | 8.4 | 1.21 | .289 | 3.59 | 7.76 |
| 8 | | A. Pettitte | 2,407 | 515 | 252 | 147 | .632 | 510 | 3.84 | 24 | 4 | 0 | 3240.2 | 3,361 | 1,384 | 1,533 | 282 | 1,003 | 54 | 2 | 41 | 13,746 | 67 | 6.68 | 2.79 | 2.40 | 0.78 | 17.5 | 7.3 | 1.35 | .308 | 4.26 | 9.33 |
| 9 |  | B. Colon | 2,399 | 519 | 235 | 167 | .585 | 510 | 3.98 | 36 | 13 | 0 | 3225.1 | 3,299 | 1,428 | 1,553 | 388 | 902 | 61 | 1 | 46 | 13,616 | 42 | 6.69 | 2.52 | 2.66 | 1.08 | 17.6 | 6.6 | 1.30 | .295 | 4.33 | 9.21 |
| 10 | | M. Mussina | 2,352 | 427 | 208 | 127 | .621 | 426 | 3.76 | 40 | 17 | 0 | 2785.2 | 2,746 | 1,164 | 1,256 | 296 | 606 | 52 | 0 | 22 | 11,457 | 56 | 7.60 | 1.96 | 3.88 | 0.96 | 20.5 | 5.3 | 1.20 | .301 | 4.06 | 8.87 |
| 11 |  | F. Hernandez | 2,286 | 364 | 156 | 111 | .584 | 364 | 3.18 | 25 | 11 | 0 | 2442.1 | 2,196 | 862 | 960 | 209 | 698 | 83 | 0 | 16 | 10,024 | 135 | 8.42 | 2.57 | 3.28 | 0.77 | 22.8 | 7.0 | 1.18 | .294 | 3.54 | 8.09 |
| 12 |  | J. Verlander | 2,255 | 362 | 177 | 109 | .619 | 362 | 3.51 | 23 | 7 | 0 | 2400.0 | 2,129 | 935 | 1,016 | 226 | 728 | 82 | 0 | 23 | 9,931 | 75 | 8.46 | 2.73 | 3.10 | 0.85 | 22.7 | 7.3 | 1.19 | .287 | 3.81 | 7.98 |
| 13 | | J. Peavy | 2,207 | 388 | 152 | 126 | .547 | 377 | 3.63 | 15 | 6 | 0 | 2377.0 | 2,134 | 960 | 1,011 | 259 | 708 | 78 | 3 | 42 | 9,838 | 46 | 8.36 | 2.68 | 3.12 | 0.98 | 22.4 | 7.2 | 1.20 | .285 | 3.83 | 8.08 |
| 14 | | J. Lackey | 2,205 | 427 | 180 | 140 | .563 | 426 | 3.90 | 18 | 8 | 0 | 2727.0 | 2,761 | 1,183 | 1,290 | 296 | 781 | 124 | 0 | 29 | 11,557 | 116 | 7.28 | 2.58 | 2.82 | 0.98 | 19.1 | 6.8 | 1.30 | .302 | 4.26 | 9.11 |
| 15 | | C. Hamels | 2,137 | 344 | 138 | 96 | .590 | 343 | 3.31 | 15 | 7 | 0 | 2247.0 | 2,004 | 826 | 882 | 250 | 604 | 67 | 0 | 41 | 9,195 | 44 | 8.56 | 2.42 | 3.54 | 1.00 | 23.2 | 6.6 | 1.16 | .286 | 3.53 | 8.03 |
| 16 | | R. Halladay | 2,117 | 416 | 203 | 105 | .659 | 390 | 3.38 | 67 | 20 | 1 | 2749.1 | 2,646 | 1,034 | 1,135 | 236 | 592 | 81 | 6 | 28 | 11,287 | 56 | 6.93 | 1.94 | 3.58 | 0.77 | 18.8 | 5.2 | 1.18 | .292 | 3.72 | 8.66 |
| 17 |  | Z. Greinke | 2,105 | 401 | 161 | 103 | .610 | 360 | 3.41 | 16 | 5 | 1 | 2325.2 | 2,191 | 882 | 947 | 229 | 563 | 59 | 8 | 20 | 9,563 | 69 | 8.15 | 2.18 | 3.74 | 0.89 | 22.0 | 5.9 | 1.18 | .297 | 3.66 | 8.48 |
| 18 | | K. Millwood | 2,083 | 451 | 169 | 152 | .526 | 443 | 4.11 | 22 | 6 | 0 | 2720.1 | 2,770 | 1,243 | 1,357 | 296 | 843 | 74 | 3 | 46 | 11,616 | 67 | 6.89 | 2.79 | 2.47 | 0.98 | 17.9 | 7.3 | 1.33 | .297 | 4.49 | 9.16 |
| 19 | | T. Hudson | 2,080 | 482 | 222 | 133 | .625 | 479 | 3.49 | 26 | 13 | 0 | 3126.2 | 2,957 | 1,213 | 1,319 | 248 | 917 | 124 | 0 | 84 | 13,005 | 84 | 5.99 | 2.64 | 2.27 | 0.71 | 16.0 | 7.1 | 1.24 | .281 | 3.80 | 8.51 |
| 20 | | R. Dempster | 2,075 | 579 | 132 | 133 | .498 | 351 | 4.35 | 11 | 3 | 87 | 2387.0 | 2,347 | 1,154 | 1,250 | 267 | 1,071 | 91 | 186 | 47 | 10,412 | 80 | 7.82 | 4.04 | 1.94 | 1.01 | 19.9 | 10.3 | 1.43 | .301 | 4.71 | 8.85 |
| 21 | | D. Haren | 2,013 | 391 | 153 | 131 | .539 | 380 | 3.75 | 16 | 6 | 1 | 2419.2 | 2,357 | 1,009 | 1,105 | 305 | 500 | 67 | 4 | 39 | 10,022 | 98 | 7.49 | 1.86 | 4.03 | 1.13 | 20.1 | 5.0 | 1.18 | .288 | 4.11 | 8.77 |
| 22 |  | C. Kershaw | 1,996 | 276 | 133 | 62 | .682 | 274 | 2.37 | 24 | 15 | 0 | 1836.0 | 1,357 | 483 | 527 | 115 | 487 | 29 | 1 | 27 | 7,217 | 70 | 9.78 | 2.39 | 4.10 | 0.56 | 27.7 | 6.7 | 1.00 | .271 | 2.58 | 6.65 |
| 23 | | J. Shields | 1,993 | 355 | 134 | 116 | .536 | 354 | 3.89 | 23 | 9 | 0 | 2311.0 | 2,284 | 999 | 1,083 | 303 | 625 | 85 | 0 | 20 | 9,675 | 92 | 7.76 | 2.43 | 3.19 | 1.18 | 20.6 | 6.5 | 1.26 | .297 | 4.22 | 8.89 |
| 24 | | T. Wakefield | 1,991 | 578 | 177 | 167 | .515 | 418 | 4.52 | 22 | 2 | 22 | 2914.0 | 2,858 | 1,463 | 1,659 | 393 | 1,069 | 173 | 77 | 30 | 12,605 | 121 | 6.15 | 3.30 | 1.86 | 1.21 | 15.8 | 8.5 | 1.35 | .275 | 5.12 | 8.83 |
| 25 | | J. Santana | 1,988 | 360 | 139 | 78 | .641 | 284 | 3.20 | 15 | 10 | 1 | 2025.2 | 1,726 | 721 | 773 | 220 | 567 | 36 | 23 | 13 | 8,262 | 68 | 8.83 | 2.52 | 3.51 | 0.98 | 24.1 | 6.9 | 1.13 | .276 | 3.43 | 7.67 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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