Between July 22, 1972 and August 8, 1994, Nolan Ryan fanned the most hitters, with 5,068 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | N. Ryan | 5,068 | 681 | 284 | 247 | .535 | 678 | 3.16 | 199 | 54 | 1 | 4736.0 | 3,468 | 1,665 | 1,904 | 278 | 2,371 | 127 | 3 | 64 | 19,774 | 245 | 9.63 | 4.51 | 2.14 | 0.53 | 25.6 | 12.0 | 1.23 | .267 | 3.62 | 6.59 |
| 2 |  | B. Blyleven | 3,218 | 603 | 252 | 214 | .541 | 599 | 3.37 | 215 | 52 | 0 | 4357.0 | 4,076 | 1,631 | 1,810 | 377 | 1,178 | 142 | 1 | 61 | 18,001 | 105 | 6.65 | 2.43 | 2.73 | 0.78 | 17.9 | 6.5 | 1.21 | .283 | 3.74 | 8.42 |
| 3 |  | S. Carlton | 2,990 | 528 | 239 | 176 | .576 | 514 | 3.28 | 174 | 36 | 1 | 3765.0 | 3,360 | 1,374 | 1,577 | 313 | 1,332 | 35 | 6 | 105 | 15,634 | 127 | 7.15 | 3.18 | 2.24 | 0.75 | 19.1 | 8.5 | 1.25 | .278 | 3.77 | 8.03 |
| 4 | | F. Tanana | 2,773 | 638 | 240 | 236 | .504 | 616 | 3.66 | 143 | 34 | 1 | 4188.1 | 4,063 | 1,702 | 1,910 | 448 | 1,255 | 129 | 10 | 116 | 17,641 | 119 | 5.96 | 2.70 | 2.21 | 0.96 | 15.7 | 7.1 | 1.27 | .277 | 4.10 | 8.73 |
| 5 |  | J. Morris | 2,478 | 549 | 254 | 186 | .577 | 527 | 3.90 | 175 | 28 | 0 | 3824.0 | 3,567 | 1,657 | 1,815 | 389 | 1,390 | 58 | 10 | 99 | 16,120 | 205 | 5.83 | 3.27 | 1.78 | 0.92 | 15.4 | 8.6 | 1.30 | .269 | 4.27 | 8.40 |
| 6 | | P. Niekro | 2,377 | 563 | 228 | 194 | .540 | 537 | 3.50 | 161 | 28 | 7 | 3856.0 | 3,660 | 1,499 | 1,717 | 343 | 1,441 | 88 | 17 | 56 | 16,335 | 145 | 5.55 | 3.36 | 1.65 | 0.80 | 14.6 | 8.8 | 1.32 | .274 | 4.01 | 8.54 |
| 7 |  | T. Seaver | 2,362 | 457 | 204 | 145 | .585 | 453 | 3.07 | 134 | 41 | 0 | 3260.2 | 2,754 | 1,114 | 1,223 | 273 | 992 | 45 | 1 | 86 | 13,297 | 91 | 6.52 | 2.74 | 2.38 | 0.75 | 17.8 | 7.5 | 1.15 | .258 | 3.38 | 7.60 |
| 8 | | C. Hough | 2,350 | 846 | 216 | 216 | .500 | 440 | 3.74 | 107 | 13 | 59 | 3780.0 | 3,262 | 1,570 | 1,793 | 375 | 1,650 | 174 | 232 | 44 | 16,070 | 180 | 5.60 | 3.93 | 1.42 | 0.89 | 14.6 | 10.3 | 1.30 | .251 | 4.27 | 7.77 |
| 9 | | D. Sutton | 2,315 | 529 | 229 | 166 | .580 | 525 | 3.31 | 112 | 34 | 2 | 3641.1 | 3,246 | 1,338 | 1,476 | 349 | 919 | 51 | 3 | 54 | 14,912 | 74 | 5.72 | 2.27 | 2.52 | 0.86 | 15.5 | 6.2 | 1.14 | .257 | 3.65 | 8.02 |
| 10 | | D. Eckersley | 2,243 | 848 | 188 | 153 | .551 | 361 | 3.46 | 100 | 20 | 293 | 3081.2 | 2,863 | 1,186 | 1,282 | 319 | 704 | 66 | 415 | 85 | 12,678 | 26 | 6.55 | 2.06 | 3.19 | 0.93 | 17.7 | 5.6 | 1.16 | .272 | 3.74 | 8.36 |
| 11 |  | R. Clemens | 2,194 | 325 | 172 | 93 | .649 | 324 | 2.93 | 94 | 36 | 0 | 2386.1 | 1,995 | 777 | 866 | 158 | 686 | 68 | 0 | 41 | 9,699 | 55 | 8.27 | 2.59 | 3.20 | 0.60 | 22.6 | 7.1 | 1.12 | .279 | 3.27 | 7.52 |
| 12 | | M. Langston | 2,110 | 352 | 151 | 134 | .530 | 349 | 3.74 | 77 | 17 | 0 | 2448.1 | 2,158 | 1,017 | 1,132 | 244 | 1,081 | 40 | 1 | 25 | 10,305 | 74 | 7.76 | 3.97 | 1.95 | 0.90 | 20.5 | 10.5 | 1.32 | .280 | 4.16 | 7.93 |
| 13 | | R. Reuschel | 1,988 | 550 | 211 | 188 | .529 | 524 | 3.37 | 101 | 26 | 5 | 3508.2 | 3,553 | 1,315 | 1,477 | 218 | 925 | 88 | 15 | 115 | 14,729 | 89 | 5.10 | 2.37 | 2.15 | 0.56 | 13.5 | 6.3 | 1.28 | .290 | 3.79 | 9.11 |
| 14 | | B. Welch | 1,968 | 505 | 211 | 146 | .591 | 462 | 3.47 | 61 | 28 | 8 | 3090.0 | 2,891 | 1,190 | 1,309 | 267 | 1,033 | 79 | 20 | 60 | 12,946 | 55 | 5.73 | 3.01 | 1.91 | 0.78 | 15.2 | 8.0 | 1.27 | .273 | 3.81 | 8.42 |
| 15 | | D. Martinez | 1,923 | 582 | 219 | 171 | .562 | 500 | 3.63 | 117 | 26 | 6 | 3560.2 | 3,427 | 1,436 | 1,602 | 327 | 1,034 | 98 | 40 | 60 | 14,865 | 79 | 4.86 | 2.61 | 1.86 | 0.83 | 12.9 | 7.0 | 1.25 | .270 | 4.05 | 8.66 |
| 16 | | J. Koosman | 1,882 | 459 | 161 | 163 | .497 | 392 | 3.58 | 97 | 18 | 16 | 2839.1 | 2,773 | 1,131 | 1,259 | 216 | 891 | 54 | 38 | 79 | 11,903 | 56 | 5.97 | 2.82 | 2.11 | 0.68 | 15.8 | 7.5 | 1.29 | .289 | 3.99 | 8.79 |
| 17 | | D. Gooden | 1,875 | 305 | 157 | 85 | .649 | 303 | 3.10 | 67 | 23 | 1 | 2169.2 | 1,898 | 747 | 823 | 123 | 651 | 41 | 1 | 31 | 8,898 | 47 | 7.78 | 2.70 | 2.88 | 0.51 | 21.1 | 7.3 | 1.17 | .286 | 3.41 | 7.87 |
| 18 | | F. Valenzuela | 1,854 | 372 | 150 | 130 | .536 | 359 | 3.45 | 112 | 31 | 2 | 2571.0 | 2,330 | 985 | 1,110 | 180 | 1,003 | 20 | 5 | 60 | 10,814 | 104 | 6.49 | 3.51 | 1.85 | 0.63 | 17.1 | 9.3 | 1.30 | .277 | 3.89 | 8.16 |
| 19 | | F. Viola | 1,822 | 412 | 175 | 146 | .545 | 411 | 3.67 | 74 | 16 | 0 | 2791.2 | 2,764 | 1,139 | 1,264 | 285 | 840 | 46 | 0 | 35 | 11,719 | 84 | 5.87 | 2.71 | 2.17 | 0.92 | 15.5 | 7.2 | 1.29 | .284 | 4.07 | 8.91 |
| 20 | | G. Perry | 1,795 | 386 | 164 | 149 | .524 | 384 | 3.32 | 162 | 29 | 0 | 2851.0 | 2,730 | 1,052 | 1,194 | 229 | 752 | 52 | 2 | 68 | 11,744 | 71 | 5.67 | 2.37 | 2.39 | 0.72 | 15.3 | 6.4 | 1.22 | .281 | 3.77 | 8.62 |
| 21 | | R. Guidry | 1,778 | 368 | 170 | 91 | .651 | 323 | 3.29 | 95 | 26 | 4 | 2392.0 | 2,198 | 874 | 953 | 226 | 633 | 13 | 23 | 24 | 9,794 | 56 | 6.69 | 2.38 | 2.81 | 0.85 | 18.2 | 6.5 | 1.18 | .276 | 3.59 | 8.27 |
| 22 | | V. Blue | 1,762 | 434 | 180 | 147 | .550 | 414 | 3.39 | 115 | 26 | 1 | 2882.0 | 2,602 | 1,086 | 1,212 | 224 | 1,042 | 18 | 10 | 56 | 12,006 | 91 | 5.50 | 3.25 | 1.69 | 0.70 | 14.7 | 8.7 | 1.26 | .265 | 3.78 | 8.13 |
| 23 | | F. Bannister | 1,723 | 431 | 134 | 143 | .484 | 363 | 4.06 | 62 | 16 | 0 | 2388.0 | 2,320 | 1,078 | 1,189 | 291 | 846 | 40 | 13 | 39 | 10,187 | 84 | 6.49 | 3.19 | 2.04 | 1.10 | 16.9 | 8.3 | 1.33 | .278 | 4.48 | 8.74 |
| 24 | | B. Hurst | 1,689 | 379 | 145 | 113 | .562 | 359 | 3.92 | 83 | 23 | 0 | 2417.1 | 2,463 | 1,052 | 1,143 | 258 | 740 | 28 | 5 | 42 | 10,204 | 56 | 6.29 | 2.76 | 2.28 | 0.96 | 16.6 | 7.3 | 1.33 | .294 | 4.26 | 9.17 |
| 25 | | D. Stewart | 1,683 | 507 | 165 | 122 | .575 | 332 | 3.86 | 55 | 9 | 19 | 2548.2 | 2,398 | 1,092 | 1,194 | 253 | 995 | 60 | 87 | 45 | 10,870 | 111 | 5.94 | 3.51 | 1.69 | 0.89 | 15.5 | 9.2 | 1.33 | .272 | 4.22 | 8.47 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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