Between July 4, 1923 and September 29, 1946, Lefty Grove fanned the most hitters, with 2,269 strikeouts.
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | L. Grove | 2,269 | 616 | 300 | 141 | .680 | 457 | 3.06 | 298 | 35 | 54 | 3938.1 | 3,848 | 1,341 | 1,596 | 162 | 1,184 | 41 | 123 | 16,622 | 51 | 5.19 | 2.71 | 1.92 | 0.37 | 13.7 | 7.1 | 1.28 | .284 | 3.65 | 8.79 | |
| 2 | | R. Ruffing | 1,979 | 615 | 270 | 220 | .551 | 529 | 3.78 | 334 | 45 | 18 | 4288.1 | 4,225 | 1,799 | 2,078 | 247 | 1,526 | 57 | 69 | 18,291 | 43 | 4.15 | 3.20 | 1.30 | 0.52 | 10.8 | 8.3 | 1.34 | .275 | 4.36 | 8.87 | |
| 3 | | B. Newsom | 1,948 | 517 | 194 | 202 | .490 | 444 | 4.01 | 237 | 29 | 18 | 3435.0 | 3,427 | 1,531 | 1,760 | 189 | 1,598 | 51 | 49 | 15,050 | 56 | 5.10 | 4.19 | 1.22 | 0.50 | 12.9 | 10.6 | 1.46 | .287 | 4.61 | 8.98 | |
| 4 | | D. Vance | 1,820 | 379 | 173 | 116 | .599 | 299 | 3.16 | 191 | 22 | 12 | 2577.2 | 2,413 | 906 | 1,052 | 118 | 679 | 62 | 43 | 10,678 | 29 | 6.35 | 2.37 | 2.68 | 0.41 | 17.0 | 6.4 | 1.20 | .287 | 3.67 | 8.43 | |
| 5 | | T. Bridges | 1,681 | 424 | 194 | 138 | .584 | 362 | 3.57 | 200 | 33 | 10 | 2825.2 | 2,674 | 1,122 | 1,322 | 179 | 1,193 | 35 | 47 | 12,163 | 59 | 5.35 | 3.80 | 1.41 | 0.57 | 13.8 | 9.8 | 1.37 | .275 | 4.21 | 8.52 | |
| 6 | | C. Hubbell | 1,678 | 535 | 253 | 154 | .622 | 433 | 2.98 | 260 | 36 | 33 | 3588.2 | 3,462 | 1,188 | 1,384 | 227 | 728 | 53 | 82 | 14,810 | 53 | 4.21 | 1.83 | 2.30 | 0.57 | 11.3 | 4.9 | 1.17 | .267 | 3.47 | 8.68 | |
| 7 | | B. Feller | 1,640 | 262 | 138 | 72 | .657 | 226 | 2.96 | 160 | 27 | 14 | 1891.2 | 1,476 | 622 | 691 | 70 | 1,003 | 31 | 29 | 7,999 | 50 | 7.80 | 4.77 | 1.64 | 0.33 | 20.5 | 12.5 | 1.31 | .268 | 3.29 | 7.02 | |
| 8 | | P. Derringer | 1,509 | 579 | 223 | 212 | .513 | 445 | 3.46 | 251 | 32 | 29 | 3643.0 | 3,911 | 1,401 | 1,653 | 159 | 765 | 32 | 98 | 15,404 | 50 | 3.73 | 1.89 | 1.97 | 0.39 | 9.8 | 5.0 | 1.28 | .290 | 4.08 | 9.66 | |
| 9 | | L. Gomez | 1,468 | 368 | 189 | 102 | .649 | 320 | 3.34 | 173 | 28 | 10 | 2502.0 | 2,289 | 929 | 1,090 | 139 | 1,095 | 21 | 31 | 10,712 | 39 | 5.28 | 3.94 | 1.34 | 0.50 | 13.7 | 10.2 | 1.35 | .269 | 3.92 | 8.23 | |
| 10 | | C. Root | 1,448 | 621 | 201 | 160 | .557 | 341 | 3.59 | 177 | 21 | 42 | 3171.1 | 3,231 | 1,264 | 1,452 | 190 | 880 | 77 | 179 | 13,417 | 22 | 4.11 | 2.50 | 1.65 | 0.54 | 10.8 | 6.6 | 1.30 | .281 | 4.12 | 9.17 | |
| 11 | | E. Whitehill | 1,353 | 541 | 218 | 185 | .541 | 473 | 4.36 | 226 | 16 | 11 | 3564.0 | 3,915 | 1,728 | 2,018 | 192 | 1,431 | 102 | 46 | 15,773 | 43 | 3.42 | 3.61 | 0.95 | 0.48 | 8.6 | 9.1 | 1.50 | .293 | 5.10 | 9.89 | |
| 12 | | B. Hadley | 1,316 | 528 | 161 | 165 | .494 | 355 | 4.24 | 134 | 14 | 25 | 2945.0 | 2,978 | 1,389 | 1,610 | 167 | 1,446 | 63 | 108 | 13,012 | 72 | 4.02 | 4.42 | 0.91 | 0.51 | 10.1 | 11.1 | 1.50 | .281 | 4.92 | 9.10 | |
| 13 | | V. Mungo | 1,245 | 364 | 120 | 115 | .511 | 259 | 3.48 | 123 | 20 | 16 | 2110.2 | 1,954 | 815 | 958 | 89 | 874 | 33 | 61 | 9,031 | 52 | 5.31 | 3.73 | 1.42 | 0.38 | 13.8 | 9.7 | 1.34 | .275 | 4.08 | 8.33 | |
| 14 | | L. French | 1,186 | 570 | 197 | 171 | .535 | 383 | 3.45 | 199 | 40 | 17 | 3150.1 | 3,372 | 1,207 | 1,441 | 163 | 822 | 42 | 108 | 13,458 | 34 | 3.39 | 2.35 | 1.44 | 0.47 | 8.8 | 6.1 | 1.33 | .285 | 4.12 | 9.63 | |
| 15 | | D. Dean | 1,163 | 316 | 150 | 83 | .644 | 229 | 3.03 | 154 | 26 | 31 | 1964.2 | 1,917 | 661 | 774 | 93 | 450 | 27 | 77 | 8,162 | 12 | 5.33 | 2.06 | 2.58 | 0.43 | 14.2 | 5.5 | 1.20 | .284 | 3.55 | 8.78 | |
| 16 | | L. Warneke | 1,145 | 445 | 192 | 121 | .613 | 343 | 3.19 | 192 | 30 | 14 | 2780.2 | 2,729 | 987 | 1,167 | 174 | 740 | 27 | 66 | 11,610 | 50 | 3.71 | 2.40 | 1.55 | 0.56 | 9.9 | 6.4 | 1.25 | .268 | 3.78 | 8.83 | |
| 17 | | M. Harder | 1,145 | 567 | 217 | 182 | .544 | 418 | 3.79 | 177 | 24 | 24 | 3345.1 | 3,615 | 1,407 | 1,673 | 156 | 1,091 | 58 | 94 | 14,516 | 33 | 3.08 | 2.94 | 1.05 | 0.42 | 7.9 | 7.5 | 1.41 | .287 | 4.50 | 9.73 | |
| 18 | | H. Newhouser | 1,120 | 261 | 114 | 79 | .591 | 200 | 2.72 | 117 | 23 | 11 | 1609.0 | 1,337 | 486 | 598 | 47 | 750 | 7 | 45 | 6,788 | 36 | 6.26 | 4.20 | 1.49 | 0.26 | 16.5 | 11.0 | 1.30 | .265 | 3.34 | 7.48 | |
| 19 | | C. Passeau | 1,078 | 425 | 160 | 144 | .526 | 325 | 3.25 | 187 | 25 | 19 | 2655.2 | 2,758 | 959 | 1,149 | 99 | 707 | 39 | 76 | 11,336 | 19 | 3.65 | 2.40 | 1.52 | 0.34 | 9.5 | 6.2 | 1.30 | .282 | 3.89 | 9.35 | |
| 20 | | J. Allen | 1,072 | 352 | 142 | 75 | .654 | 241 | 3.76 | 109 | 17 | 16 | 1950.1 | 1,850 | 814 | 927 | 103 | 738 | 38 | 68 | 8,296 | 68 | 4.95 | 3.41 | 1.45 | 0.48 | 12.9 | 8.9 | 1.33 | .275 | 4.28 | 8.54 | |
| 21 | | T. Lyons | 1,072 | 593 | 260 | 230 | .531 | 484 | 3.67 | 356 | 27 | 25 | 4157.2 | 4,492 | 1,696 | 2,055 | 221 | 1,124 | 31 | 90 | 17,803 | 55 | 2.32 | 2.43 | 0.95 | 0.48 | 6.0 | 6.3 | 1.35 | .278 | 4.45 | 9.72 | |
| 22 | | R. Walberg | 1,067 | 532 | 152 | 139 | .522 | 302 | 4.17 | 137 | 15 | 34 | 2584.2 | 2,733 | 1,198 | 1,395 | 160 | 1,005 | 27 | 143 | 11,282 | 40 | 3.72 | 3.50 | 1.06 | 0.56 | 9.5 | 8.9 | 1.45 | .285 | 4.86 | 9.52 | |
| 23 | | B. Walters | 1,050 | 400 | 190 | 149 | .560 | 373 | 3.18 | 236 | 40 | 4 | 2942.2 | 2,807 | 1,041 | 1,234 | 131 | 1,052 | 48 | 17 | 12,424 | 61 | 3.21 | 3.22 | 1.00 | 0.40 | 8.5 | 8.5 | 1.31 | .264 | 3.77 | 8.59 | |
| 24 | | P. Malone | 1,033 | 357 | 134 | 92 | .593 | 219 | 3.73 | 114 | 15 | 27 | 1915.0 | 1,933 | 794 | 935 | 103 | 696 | 46 | 107 | 8,275 | 51 | 4.85 | 3.27 | 1.48 | 0.48 | 12.5 | 8.4 | 1.37 | .286 | 4.39 | 9.08 | |
| 25 | | G. Earnshaw | 1,008 | 319 | 127 | 93 | .577 | 249 | 4.38 | 115 | 18 | 12 | 1914.0 | 1,981 | 932 | 1,062 | 143 | 813 | 26 | 45 | 8,450 | 55 | 4.74 | 3.82 | 1.24 | 0.67 | 11.9 | 9.6 | 1.46 | .285 | 4.99 | 9.32 | |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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