Between June 24, 1992 and September 13, 2015, Randy Johnson fanned the most batters, with 4,231 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | R. Johnson | 4,231 | 507 | 261 | 126 | .674 | 493 | 3.15 | 87 | 32 | 2 | 3454.1 | 2,795 | 1,208 | 1,356 | 348 | 1,071 | 162 | 6 | 32 | 14,082 | 79 | 11.02 | 2.79 | 3.95 | 0.91 | 30.0 | 7.6 | 1.12 | .296 | 3.53 | 7.28 |
| 2 |  | P. Martinez | 3,154 | 476 | 219 | 100 | .687 | 409 | 2.93 | 46 | 17 | 3 | 2827.1 | 2,221 | 919 | 1,006 | 239 | 760 | 141 | 23 | 30 | 11,394 | 62 | 10.04 | 2.42 | 4.15 | 0.76 | 27.7 | 6.7 | 1.05 | .279 | 3.20 | 7.07 |
| 3 |  | C. Schilling | 2,937 | 445 | 206 | 131 | .611 | 423 | 3.46 | 81 | 18 | 9 | 3029.1 | 2,790 | 1,164 | 1,222 | 335 | 612 | 50 | 21 | 33 | 12,298 | 64 | 8.73 | 1.82 | 4.80 | 1.00 | 23.9 | 5.0 | 1.12 | .294 | 3.63 | 8.29 |
| 4 |  | R. Clemens | 2,899 | 453 | 211 | 118 | .641 | 452 | 3.34 | 34 | 14 | 0 | 3013.1 | 2,600 | 1,117 | 1,230 | 241 | 1,060 | 112 | 0 | 30 | 12,543 | 98 | 8.66 | 3.17 | 2.73 | 0.72 | 23.1 | 8.5 | 1.21 | .287 | 3.67 | 7.77 |
| 5 | | M. Mussina | 2,717 | 512 | 258 | 146 | .639 | 511 | 3.74 | 53 | 22 | 0 | 3379.1 | 3,305 | 1,404 | 1,500 | 363 | 745 | 59 | 0 | 29 | 13,870 | 65 | 7.24 | 1.98 | 3.65 | 0.97 | 19.6 | 5.4 | 1.20 | .295 | 3.99 | 8.80 |
| 6 |  | G. Maddux | 2,556 | 552 | 273 | 156 | .636 | 552 | 3.03 | 73 | 26 | 0 | 3724.0 | 3,498 | 1,252 | 1,399 | 276 | 582 | 100 | 0 | 109 | 15,008 | 43 | 6.18 | 1.41 | 4.39 | 0.67 | 17.0 | 3.9 | 1.10 | .280 | 3.38 | 8.45 |
| 7 |  | CC Sabathia | 2,555 | 448 | 212 | 128 | .624 | 448 | 3.70 | 38 | 12 | 0 | 2964.1 | 2,811 | 1,219 | 1,334 | 291 | 884 | 94 | 0 | 40 | 12,364 | 64 | 7.76 | 2.68 | 2.89 | 0.88 | 20.7 | 7.1 | 1.25 | .295 | 4.05 | 8.53 |
| 8 | | J. Vazquez | 2,536 | 450 | 165 | 160 | .508 | 443 | 4.22 | 28 | 8 | 0 | 2840.0 | 2,784 | 1,331 | 1,431 | 373 | 763 | 88 | 5 | 58 | 11,935 | 76 | 8.04 | 2.42 | 3.32 | 1.18 | 21.2 | 6.4 | 1.25 | .295 | 4.53 | 8.82 |
| 9 | | A.J. Burnett | 2,487 | 431 | 163 | 155 | .513 | 426 | 3.99 | 24 | 10 | 0 | 2707.2 | 2,493 | 1,201 | 1,318 | 260 | 1,089 | 141 | 1 | 35 | 11,559 | 160 | 8.27 | 3.62 | 2.28 | 0.86 | 21.5 | 9.4 | 1.32 | .295 | 4.38 | 8.29 |
| 10 |  | J. Smoltz | 2,467 | 597 | 164 | 108 | .603 | 355 | 3.21 | 33 | 13 | 154 | 2633.0 | 2,336 | 940 | 1,016 | 223 | 695 | 47 | 204 | 70 | 10,762 | 93 | 8.43 | 2.38 | 3.55 | 0.76 | 22.9 | 6.5 | 1.15 | .288 | 3.47 | 7.98 |
| 11 | | A. Pettitte | 2,448 | 531 | 256 | 153 | .626 | 521 | 3.85 | 26 | 4 | 0 | 3316.0 | 3,448 | 1,418 | 1,572 | 288 | 1,031 | 55 | 3 | 42 | 14,074 | 69 | 6.64 | 2.80 | 2.37 | 0.78 | 17.4 | 7.3 | 1.35 | .308 | 4.27 | 9.36 |
| 12 |  | B. Colon | 2,230 | 471 | 218 | 152 | .589 | 464 | 3.96 | 36 | 13 | 0 | 2962.2 | 3,009 | 1,305 | 1,420 | 352 | 854 | 57 | 1 | 44 | 12,515 | 42 | 6.77 | 2.59 | 2.61 | 1.07 | 17.8 | 6.8 | 1.30 | .295 | 4.31 | 9.14 |
| 13 | | T. Wakefield | 2,156 | 627 | 200 | 180 | .526 | 463 | 4.41 | 33 | 6 | 22 | 3226.1 | 3,152 | 1,582 | 1,791 | 418 | 1,205 | 186 | 78 | 33 | 13,939 | 134 | 6.01 | 3.36 | 1.79 | 1.17 | 15.5 | 8.6 | 1.35 | .274 | 5.00 | 8.79 |
| 14 |  | F. Hernandez | 2,126 | 331 | 142 | 100 | .587 | 331 | 3.11 | 25 | 11 | 0 | 2243.2 | 2,002 | 775 | 862 | 180 | 621 | 70 | 0 | 16 | 9,169 | 124 | 8.53 | 2.49 | 3.42 | 0.72 | 23.2 | 6.8 | 1.17 | .295 | 3.46 | 8.03 |
| 15 | | R. Halladay | 2,117 | 416 | 203 | 105 | .659 | 390 | 3.38 | 67 | 20 | 1 | 2749.1 | 2,646 | 1,034 | 1,135 | 236 | 592 | 81 | 6 | 28 | 11,287 | 56 | 6.93 | 1.94 | 3.58 | 0.77 | 18.8 | 5.2 | 1.18 | .292 | 3.72 | 8.66 |
| 16 | | J. Peavy | 2,087 | 353 | 145 | 117 | .553 | 352 | 3.56 | 15 | 6 | 0 | 2234.1 | 1,982 | 883 | 931 | 240 | 668 | 76 | 0 | 41 | 9,225 | 42 | 8.41 | 2.69 | 3.12 | 0.97 | 22.6 | 7.2 | 1.19 | .283 | 3.75 | 7.98 |
| 17 | | K. Millwood | 2,083 | 451 | 169 | 152 | .526 | 443 | 4.11 | 22 | 6 | 0 | 2720.1 | 2,770 | 1,243 | 1,357 | 296 | 843 | 74 | 3 | 46 | 11,616 | 67 | 6.89 | 2.79 | 2.47 | 0.98 | 17.9 | 7.3 | 1.33 | .297 | 4.49 | 9.16 |
| 18 | | T. Hudson | 2,075 | 478 | 221 | 132 | .626 | 475 | 3.49 | 26 | 13 | 0 | 3112.2 | 2,946 | 1,207 | 1,312 | 248 | 906 | 122 | 0 | 84 | 12,942 | 84 | 6.00 | 2.62 | 2.29 | 0.72 | 16.0 | 7.0 | 1.24 | .281 | 3.79 | 8.52 |
| 19 | | R. Dempster | 2,075 | 579 | 132 | 133 | .498 | 351 | 4.35 | 11 | 3 | 87 | 2387.0 | 2,347 | 1,154 | 1,250 | 267 | 1,071 | 91 | 186 | 47 | 10,412 | 80 | 7.82 | 4.04 | 1.94 | 1.01 | 19.9 | 10.3 | 1.43 | .301 | 4.71 | 8.85 |
| 20 | | T. Glavine | 2,025 | 527 | 241 | 148 | .620 | 527 | 3.49 | 33 | 16 | 0 | 3403.1 | 3,339 | 1,321 | 1,431 | 282 | 1,187 | 50 | 0 | 113 | 14,370 | 39 | 5.36 | 3.14 | 1.71 | 0.75 | 14.1 | 8.3 | 1.33 | .282 | 3.78 | 8.83 |
| 21 | | K. Brown | 2,018 | 379 | 166 | 108 | .606 | 369 | 3.15 | 54 | 14 | 0 | 2533.0 | 2,359 | 887 | 1,013 | 165 | 643 | 113 | 1 | 31 | 10,460 | 77 | 7.17 | 2.28 | 3.14 | 0.59 | 19.3 | 6.1 | 1.19 | .292 | 3.60 | 8.38 |
| 22 | | J. Moyer | 2,006 | 555 | 235 | 155 | .603 | 527 | 4.19 | 26 | 8 | 0 | 3374.0 | 3,465 | 1,571 | 1,682 | 443 | 873 | 127 | 6 | 48 | 14,281 | 35 | 5.35 | 2.33 | 2.30 | 1.18 | 14.0 | 6.1 | 1.29 | .279 | 4.49 | 9.24 |
| 23 | | D. Haren | 2,002 | 388 | 151 | 131 | .535 | 377 | 3.77 | 16 | 6 | 1 | 2402.0 | 2,348 | 1,007 | 1,101 | 305 | 499 | 66 | 4 | 39 | 9,957 | 97 | 7.50 | 1.87 | 4.01 | 1.14 | 20.1 | 5.0 | 1.19 | .288 | 4.13 | 8.80 |
| 24 | | J. Santana | 1,988 | 360 | 139 | 78 | .641 | 284 | 3.20 | 15 | 10 | 1 | 2025.2 | 1,726 | 721 | 773 | 220 | 567 | 36 | 23 | 13 | 8,262 | 68 | 8.83 | 2.52 | 3.51 | 0.98 | 24.1 | 6.9 | 1.13 | .276 | 3.43 | 7.67 |
| 25 | | L. Hernandez | 1,976 | 519 | 178 | 177 | .501 | 474 | 4.44 | 50 | 9 | 1 | 3189.0 | 3,525 | 1,572 | 1,686 | 362 | 1,066 | 78 | 17 | 86 | 13,816 | 41 | 5.58 | 3.01 | 1.85 | 1.02 | 14.3 | 7.7 | 1.44 | .306 | 4.76 | 9.95 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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