Between June 27, 1996 and September 30, 2018, Randy Johnson struck out the most hitters, with 3,193 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | R. Johnson | 3,193 | 392 | 199 | 102 | .661 | 379 | 3.16 | 59 | 22 | 1 | 2631.0 | 2,187 | 923 | 1,045 | 287 | 721 | 123 | 5 | 28 | 10,697 | 49 | 10.92 | 2.47 | 4.43 | 0.98 | 29.8 | 6.7 | 1.11 | .298 | 3.57 | 7.48 |
| 2 |  | CC Sabathia | 2,986 | 538 | 246 | 153 | .617 | 538 | 3.70 | 38 | 12 | 0 | 3470.0 | 3,292 | 1,426 | 1,559 | 355 | 1,060 | 120 | 0 | 44 | 14,521 | 74 | 7.74 | 2.75 | 2.82 | 0.92 | 20.6 | 7.3 | 1.25 | .294 | 4.04 | 8.54 |
| 3 |  | J. Verlander | 2,706 | 419 | 204 | 123 | .624 | 419 | 3.39 | 24 | 8 | 0 | 2759.0 | 2,398 | 1,039 | 1,124 | 272 | 808 | 92 | 0 | 27 | 11,346 | 83 | 8.83 | 2.64 | 3.35 | 0.89 | 23.8 | 7.1 | 1.16 | .285 | 3.67 | 7.82 |
| 4 |  | P. Martinez | 2,598 | 339 | 177 | 76 | .700 | 337 | 2.84 | 41 | 13 | 0 | 2264.2 | 1,774 | 714 | 783 | 194 | 557 | 114 | 1 | 20 | 9,104 | 45 | 10.32 | 2.21 | 4.66 | 0.77 | 28.5 | 6.1 | 1.03 | .280 | 3.11 | 7.05 |
| 5 |  | J. Vazquez | 2,536 | 450 | 165 | 160 | .508 | 443 | 4.22 | 28 | 8 | 0 | 2840.0 | 2,784 | 1,331 | 1,431 | 373 | 763 | 88 | 5 | 58 | 11,935 | 76 | 8.04 | 2.42 | 3.32 | 1.18 | 21.2 | 6.4 | 1.25 | .295 | 4.53 | 8.82 |
| 6 |  | B. Colon | 2,535 | 565 | 247 | 188 | .568 | 552 | 4.12 | 38 | 13 | 0 | 3461.2 | 3,593 | 1,584 | 1,719 | 439 | 948 | 64 | 2 | 47 | 14,655 | 45 | 6.59 | 2.46 | 2.67 | 1.14 | 17.3 | 6.5 | 1.31 | .296 | 4.47 | 9.34 |
| 7 | | A.J. Burnett | 2,513 | 435 | 164 | 157 | .511 | 430 | 3.99 | 24 | 10 | 0 | 2731.1 | 2,519 | 1,210 | 1,328 | 263 | 1,100 | 143 | 1 | 35 | 11,665 | 161 | 8.28 | 3.62 | 2.28 | 0.87 | 21.5 | 9.4 | 1.32 | .295 | 4.38 | 8.30 |
| 8 |  | F. Hernandez | 2,467 | 404 | 168 | 128 | .568 | 403 | 3.34 | 25 | 11 | 0 | 2658.0 | 2,402 | 986 | 1,099 | 247 | 780 | 99 | 0 | 16 | 10,959 | 151 | 8.35 | 2.64 | 3.16 | 0.84 | 22.5 | 7.1 | 1.20 | .293 | 3.72 | 8.13 |
| 9 |  | M. Scherzer | 2,449 | 338 | 159 | 82 | .660 | 329 | 3.22 | 10 | 5 | 0 | 2117.2 | 1,739 | 757 | 817 | 236 | 585 | 78 | 2 | 17 | 8,585 | 65 | 10.41 | 2.49 | 4.19 | 1.00 | 28.5 | 6.8 | 1.10 | .287 | 3.47 | 7.39 |
| 10 | | C. Schilling | 2,448 | 354 | 171 | 102 | .626 | 332 | 3.43 | 64 | 14 | 9 | 2400.1 | 2,220 | 914 | 948 | 274 | 448 | 39 | 21 | 16 | 9,700 | 49 | 9.18 | 1.68 | 5.46 | 1.03 | 25.2 | 4.6 | 1.11 | .300 | 3.55 | 8.32 |
| 11 |  | Z. Greinke | 2,435 | 455 | 187 | 118 | .613 | 414 | 3.39 | 16 | 5 | 1 | 2663.1 | 2,486 | 1,002 | 1,078 | 271 | 637 | 65 | 8 | 23 | 10,919 | 84 | 8.23 | 2.15 | 3.82 | 0.92 | 22.3 | 5.8 | 1.17 | .295 | 3.64 | 8.40 |
| 12 | | C. Hamels | 2,415 | 395 | 156 | 114 | .578 | 394 | 3.40 | 17 | 7 | 0 | 2553.0 | 2,280 | 964 | 1,036 | 293 | 710 | 93 | 0 | 42 | 10,484 | 56 | 8.51 | 2.50 | 3.40 | 1.03 | 23.0 | 6.8 | 1.17 | .285 | 3.65 | 8.04 |
| 13 | | J. Lackey | 2,294 | 448 | 188 | 147 | .561 | 446 | 3.92 | 18 | 8 | 0 | 2840.1 | 2,862 | 1,237 | 1,347 | 319 | 815 | 133 | 0 | 32 | 12,030 | 125 | 7.27 | 2.58 | 2.81 | 1.01 | 19.1 | 6.8 | 1.29 | .300 | 4.27 | 9.07 |
| 14 |  | C. Kershaw | 2,275 | 318 | 153 | 69 | .689 | 316 | 2.39 | 25 | 15 | 0 | 2096.1 | 1,570 | 557 | 609 | 145 | 536 | 31 | 1 | 27 | 8,252 | 81 | 9.77 | 2.30 | 4.24 | 0.62 | 27.6 | 6.5 | 1.00 | .271 | 2.61 | 6.74 |
| 15 | | A. Pettitte | 2,267 | 483 | 233 | 140 | .625 | 479 | 3.82 | 22 | 4 | 0 | 3039.1 | 3,153 | 1,289 | 1,431 | 261 | 927 | 53 | 1 | 39 | 12,891 | 60 | 6.71 | 2.75 | 2.45 | 0.77 | 17.6 | 7.2 | 1.34 | .308 | 4.24 | 9.34 |
| 16 | | J. Shields | 2,234 | 407 | 145 | 139 | .511 | 405 | 4.01 | 23 | 9 | 0 | 2616.0 | 2,581 | 1,167 | 1,267 | 361 | 746 | 97 | 1 | 22 | 10,993 | 107 | 7.69 | 2.57 | 2.99 | 1.24 | 20.3 | 6.8 | 1.27 | .294 | 4.36 | 8.88 |
| 17 |  | R. Clemens | 2,211 | 343 | 169 | 80 | .679 | 342 | 3.21 | 22 | 10 | 0 | 2265.0 | 1,929 | 807 | 888 | 177 | 779 | 74 | 0 | 21 | 9,374 | 74 | 8.79 | 3.10 | 2.84 | 0.70 | 23.6 | 8.3 | 1.20 | .286 | 3.53 | 7.66 |
| 18 | | J. Peavy | 2,207 | 388 | 152 | 126 | .547 | 377 | 3.63 | 15 | 6 | 0 | 2377.0 | 2,134 | 960 | 1,011 | 259 | 708 | 78 | 3 | 42 | 9,838 | 46 | 8.36 | 2.68 | 3.12 | 0.98 | 22.4 | 7.2 | 1.20 | .285 | 3.83 | 8.08 |
| 19 |  | J. Lester | 2,190 | 381 | 177 | 98 | .644 | 380 | 3.50 | 15 | 4 | 0 | 2366.0 | 2,182 | 920 | 995 | 232 | 768 | 79 | 0 | 8 | 9,831 | 58 | 8.33 | 2.92 | 2.85 | 0.88 | 22.3 | 7.8 | 1.25 | .297 | 3.78 | 8.30 |
| 20 | | M. Mussina | 2,158 | 395 | 189 | 119 | .614 | 394 | 3.79 | 32 | 13 | 0 | 2553.0 | 2,524 | 1,074 | 1,155 | 272 | 549 | 51 | 0 | 20 | 10,495 | 54 | 7.61 | 1.94 | 3.93 | 0.96 | 20.6 | 5.2 | 1.20 | .302 | 4.07 | 8.90 |
| 21 | | R. Halladay | 2,117 | 416 | 203 | 105 | .659 | 390 | 3.38 | 67 | 20 | 1 | 2749.1 | 2,646 | 1,034 | 1,135 | 236 | 592 | 81 | 6 | 28 | 11,287 | 56 | 6.93 | 1.94 | 3.58 | 0.77 | 18.8 | 5.2 | 1.18 | .292 | 3.72 | 8.66 |
| 22 | | K. Millwood | 2,083 | 451 | 169 | 152 | .526 | 443 | 4.11 | 22 | 6 | 0 | 2720.1 | 2,770 | 1,243 | 1,357 | 296 | 843 | 74 | 3 | 46 | 11,616 | 67 | 6.89 | 2.79 | 2.47 | 0.98 | 17.9 | 7.3 | 1.33 | .297 | 4.49 | 9.16 |
| 23 | | T. Hudson | 2,080 | 482 | 222 | 133 | .625 | 479 | 3.49 | 26 | 13 | 0 | 3126.2 | 2,957 | 1,213 | 1,319 | 248 | 917 | 124 | 0 | 84 | 13,005 | 84 | 5.99 | 2.64 | 2.27 | 0.71 | 16.0 | 7.1 | 1.24 | .281 | 3.80 | 8.51 |
| 24 | | R. Dempster | 2,075 | 579 | 132 | 133 | .498 | 351 | 4.35 | 11 | 3 | 87 | 2387.0 | 2,347 | 1,154 | 1,250 | 267 | 1,071 | 91 | 186 | 47 | 10,412 | 80 | 7.82 | 4.04 | 1.94 | 1.01 | 19.9 | 10.3 | 1.43 | .301 | 4.71 | 8.85 |
| 25 | | D. Haren | 2,013 | 391 | 153 | 131 | .539 | 380 | 3.75 | 16 | 6 | 1 | 2419.2 | 2,357 | 1,009 | 1,105 | 305 | 500 | 67 | 4 | 39 | 10,022 | 98 | 7.49 | 1.86 | 4.03 | 1.13 | 20.1 | 5.0 | 1.18 | .288 | 4.11 | 8.77 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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